Study by NTU professors provides important insight into apoptosis or programmed cell death
... shuts down.
Too little or too much apoptosis
plays a role in a great many diseases. When ... - for example, in cancer and leukemia. When apoptosis
works overly well, it kills too many cells and ...
While it is established that cells undergo apoptosis
when they are damaged by mechanical injury, ...
Genes that control cell death fingered in age-related hearing loss
... to research published online in the journal apoptosis
a journal devoted to the topic of cell suicide, ... activity differed between the two groups.
itself is certainly nothing new. Such programmed ... cells that are damaged or no longer needed. When apoptosis
happens, a cell's structure breaks up, and the ...
Refusal of suicide order: Why tumor cells become resistant
... cells simply degrade a protein that triggers apoptosis
in the case of DNA damage. Blocking this protein degradation might set apoptosis
back in operation and, thus, increase the ... suicide!
Among the proteins that trigger apoptosis
after severe DNA damage is the HIPK2 molecule. ...
Programmed death boosts business
... to undergo spontaneous self destruction. apoptosis
is a very useful process. Under normal ... to separate for form tiny hands, for instance. apoptosis
also allows the body to eradicate errant cells ... and Fernndez-Gonzlez suggest that business adopt apoptosis
as a standard procedure within the organisation. ...
Early exposure to common weed killer impairs amphibian development
... hemorrhaging, intestinal coiling, edema and apoptosis
(normal cell death that is "programmed" by the ... exposed tadpoles for increased incidence of apoptosis
by measuring levels of active caspase-3 in the ... and midbrain. Caspase-3 is a protein needed for apoptosis
to occur. They conducted measurements after 6, ...
JCI table of contents: Aug. 9, 2007
... the heart (cardiomyocytes) by a process known as apoptosis
and decreased cardiomyocyte expression of the ... cardiomyocytes. However, although cardiomyocyte apoptosis
was decreased, it was not completely eliminated. ... revealed that Bcl-2 inhibited only one pathway of apoptosis
activated by the sustained inflammatory response ...
Cancer: The cost of being smarter than chimps?
... liver, kidneys and heart. They found distinct differences in the way apoptosis
or programmed cell death operates, suggesting that humans do not "self-destroy" cells as effectively as chimpanzees do. apoptosis
is one of the primary mechanisms by which our bodies destroy cancer cells. ...
Burnham researchers discover 'on switch' for cell death signaling mechanism
... inducing signaling complex (DISC), which is responsible for triggering apoptosis
(programmed cell death).
The research, performed by Stefan Riedl, ... on many diseases such as cancer."
This work, by scientists of the apoptosis
& Cell Death program at the Burnham Cancer Center and their collaborators, ...
Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds
... these flavonoids, which have antioxidant activity, and which cause apoptosis
in several cancer cell lines but not in normal cells. Based on those ... to the extract in different doses and found the marked effect in causing apoptosis
in these cells at one of the higher doses.
They also discovered that ...
Novel structure proteins could play a role in apoptosis
... University's College of Science and Technology, could be involved in apoptosis
or programmed cell death.
NSPs were discovered four years ago by ... of both proteins was lowered simultaneously, D'Agostino noted, no apoptosis
occurred, leading the researchers to conclude that at least in this model ...
Potential new therapeutic molecular target to fight cancer
... cyclin-dependent kinase inhibitor. This p21 regulates the cell cycle, and apoptosis
or programmed cell suicide, mediated by doxorubicin. Human colon and ... findings suggest that SphK2 influences the balance between cytostasis, and apoptosis
of human cancer cells, Spiegel said. Cytostasis refers to the stoppage of ...
Study reveals a key to blood vessel growth and possible drug target
... balance between cell survival and cell death (apoptosis). A cell induces apoptosis
when it detects that it is irreparably damaged. The integrity of the blood ... understanding how to genetically control endothelial cell survival and apoptosis
is critical to future work in these areas, Stainier said.
Dominant cholesterol-metabolism ideas challenged by new research
... proposed that ABCA1 might be part of the molecular
machinery involved in apoptosis
and macrophage activity.
The Penn State-Amherst team performed a complex ... the phospholipids. They also examined the
role of ABCA1 enzyme in apoptosis
and macrophage activity.
A key part of the study was using cells from ...
Protein that promotes cancer cell growth identified
... of cell death proteins are missing from human tumors, allowing cancer cells to ignore the cues that keep their growth in check. Cells that can evade apoptosis
have a clear growth advantage. Because Caspase-8 is involved in programmed cell death, it would seem that reducing Caspase-8 in cancer cells would ...
How mitochondria get their membranes bent
... of molecules. Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored in this compartment. When apoptosis
is triggered, the pores enlarge and cytochrome c is released into the cytosol. Thus, understanding of how the pore diameter and the shape of the ...
American Society for Microbiology honors George Liu
... of Group B streptococcus (GBS) hemolysin. He showed that this toxin has an unusual dose effect that causes lysis of phagocytes at a higher dose, apoptosis
at an intermediate dose, and downregulation of inflammation at a low dose. The golden color imparted by carotenoid pigments of Staphylococcus aureus ...
Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue
... into a variety of cell types.
"Injecting MSCs or factors released by MSCs improved ventricular function, promoted myocardial regeneration, lessened apoptosis
(cell death) and fibrotic remodeling, recruited bone marrow progenitor cells and induced myocardial expression of multiple growth factor genes," Lee ...
Burnham researchers present at 100th AACR Meeting
... Novel Pathway for XIAP Degradation
Shi Ranxin, Ph.D., who will present two papers: Cyclosporin A Sensitizes Cancer Cells to Death Receptor-Mediated apoptosis
and Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NFκB Activation Induced by Protein Kinase C and Antigen Receptors.
Time (and PPAR-beta/delta) heals all wounds
... after wounding (1). But cultured keratinocytes from these mice don't proliferate any faster than normal cells and, in fact, are more susceptible to apoptosis
(2). According to Nguan Soon Tan, this discrepancy was the first indication that PPARβ/δ might regulate crosstalk between layers of the ...
Cancer: Another step towards medication
... factor, controls the expression of up to 15 % of all human genes. When this gene mutates to an oncogene, the cell proliferates excessively and apoptosis
is inhibited. Thereby the gene plays a decisive role in the development of many tumors. The problem is that pharmacological substances do not target ...
Small molecules block cancer gene
... five of the six had some activity in stopping Stat3, one called 188 was most effective. Three of the six worked to induce programmed cell death or apoptosis
in breast cancer cell lines.
"It induced death in those breast cancer cells that depend for their survival on Stat3," said Tweardy.
Scripps research team identifies key molecules that inhibit viral production
... in the host cell; studies have suggested that these core-core or core-other protein interactions can modulate various functions including signaling, apoptosis
or programmed cell death, lipid metabolism, and gene transcription.
The core protein is particularly important in the assembly of the hepatitis C ...
The Burnham Buzz, February 2009
... in cancerous cells.
Stefan Riedl, Ph.D., got the first look at the molecular structure of the protein complex that controls apoptosis
(programmed cell death). Fas and Fas associated death domain protein (FADD) make up the death inducing signaling complex (DISC). The Fas-FADD DISC is ...
UNC study: Tinkering with the circadian clock can suppress cancer growth
... can eliminate cancerous cells. Sancar said this tactic essentially makes cancer cells more likely to commit cell suicide through a process known as apoptosis
in response to the stresses of UV radiation or chemotherapy.
"These results suggest that altering the function of this clock gene, at least in ...
Scattered light rapidly detects tumor response to chemotherapy
... the light scattered by these bodies to detect the apoptotic changes in real time.
"The new technology allowed us to detect the tell-tale signs of apoptosis
in human breast cancer cells in as little as 90 minutes," said Adam Wax, associate professor of biomedical engineering and senior member of the ...
JCI online early table of contents: Jan. 19, 2009
TITLE: Pim-1specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis
Pei Xiang Xing
Burnet Institute Incorporating Austin Research Institute, Heidelberg, Victoria, Australia.
Chemopreventive agents in black raspberries identified
... at the Ohio State Comprehensive Cancer Center found that anthocyanins, a class of flavonoids in black raspberries, inhibited growth and stimulated apoptosis
in the esophagus of rats treated with an esophageal carcinogen.
"Our data provide strong evidence that anthocyanins are important for cancer ...
Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish
... is the first to describe how neurons (nerve cells) and cancer cells achieve the common goal of inhibiting the series of biochemical events called apoptosis
that eventually causes cells to break down and die.
That's good in the case of neurons, but bad when it comes to cancer.
"In neurons, ...
Mechanisms of cardiovascular disease and cancer give clues to new therapies
... as acute coronary syndrome and stroke. However some endothelins are also signalling molecules promoting growth and retarding the natural process of apoptosis
(cell death) involved in eliminating cells. Some tumour cells, for example in ovarian carcinoma, exploit endothelins to suppress their death while ...
American Chemical Society's Weekly PressPac -- Nov. 19, 2008
... cells were functional and effective, the researchers say. MTS
ARTICLE #4 FOR IMMEDIATE RELEASE
"Caspase-3 Gene Silencing for Inhibiting apoptosis
in Insulinoma Cells and Human Islets"
DOWNLOAD FULL TEXT ARTICLE
Ram I. Mahato, Ph.D.
University of Tennessee Health Science ...
3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
... for pre-clinical testing against human neurodegenerative conditions. According to Dr. D'Mello, "Studies into the mechanisms underlying neuronal apoptosis
has identified several molecules that can be targeted in developing drugs to treat neurodegenerative diseases. Some of these have been tested in ...
Researchers at UH explore use of fat cells as heart attack therapy
... But, with the stromal cells present we see a reduction in cell damage," Kleis explained. "The cardiomyocytes not treated with ADSCs showed apoptosis
programmed cell death at 15 percent; whereas, the ones that were co-cultured showed it at 3 percent."
Kleis said his team is planning additional ...
Burnham researchers turn cancer friend into cancer foe
... October 7 edition of Cancer Cell , may lead to new cancer treatments.
The Bcl-2 protein has long been implicated in protecting cancer cells from apoptosis
(programmed cell death), the process that usually keeps cancer cells in check. This peptide (called NuBCP-9) and its enantiomer (mirror-image ...
Cutting calories could limit muscle wasting in later years
... findings are another step forward in linking iron to muscle cell death, but there are more questions researchers must answer.
"They've shown that apoptosis
(cell death) goes up in aging muscle but where does that happen?" Hepple asked. "There are more than muscle cells in muscle. (For example) in older ...
Cardiac cell transplant studies show promise in cardiac tissue repair
... new strategy for myocardial repair."
Cardiomyocyte survival was counted at one, three and seven days after culture to see if protection against apoptosis
Cardiac function was measured before and 28 days after treatment. Results showed that cardiomyocyte survival increased ...
Oxidative stress: Mechanism of cell death clarified
... coincidence, but accumulate due to increased activity of a specific enzyme of the arachidonic acid metabolism, the 12/15-lipoxygenase. Activation of apoptosis
inducing factor (AIF), evidenced by its relocation from mitochondria to the cell nucleus, was identified as another important event in this signaling ...
Normal-looking sperm may have serious damage; scientists urge more care in selection
"The origin of DNA fragmentation can be multi factorial," said Mr. Avendao. "Oxidative stress (mainly due to reproductive tract infections) and apoptosis
are the most studied, but other factors as age, smoking, exposure to air pollution and abnormal testicular warming are believed to increase the ...
T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
... compared to controls where T-cadherin is present: The absence of T-cadherin delays tumor growth by an average of 10 days, decreases tumor size, and apoptosis
markers, indicators of cell suicide, are six times higher. The tumor-bearing knockouts live an average of 18.5 days longer than their wild-type ...
CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
... group, 11, or 45 percent, affect cellular signaling pathways critical to neuronal cell growth, migration, proliferation, differentiation, apoptosis
and synapse formation. Some of the affected pathways have turned up in past studies of schizophrenia, notably those involving signaling in ...
Mounting evidence shows red wine antioxidant kills cancer
... be safe as long as a physician is monitoring.)
They evaluated the mitochondria function of the cells treated with resveratrol, and also measured apoptosis
(cell death), the level of reactive oxygen species in the cells, and how the cell membranes responded to the antioxidant.
Laboratory experiments ...