Navigation Links
Antigens in Biological News

Implants mimic infection to rally immune system against tumors

... plastic disks impregnated with tumor-specific antigens and implanted under the skin can reprogram the ... an implant's pores, where they are exposed to antigens specific to the type of tumor being targeted. The ... could also be loaded with bacterial or viral antigens to safeguard against an array of infectious ...

'Femtomolar optical tweezers' may enable sensitive blood tests

... containing infectious particles (antigens). The antigens then stick to the antibodies on the sphere, ... force needed to break off the antibodies from the antigens and thus count the number of individual antigens that were bound to the sphere. This in turn can ...

The right messenger for a healthy immune response

... fragments of pathogens, so-called antigens. Immune cells present these antigens on their surface and in this way communicate with one another: antigens are the "wanted posters" of the virus or the bacterium which has to be ...

UTSA, Health Science Center collaborate with Merck & Co. to develop chlamydia vaccine

... a vaccine composed of a select group of recombinant C. trachomatis antigens can successfully accelerate bacterial clearance, and importantly, preserve ... working hard with the Merck group to identify the most efficacious vaccine antigens for inducing anti-chlamydial immunity. They are also planning to apply ...

Molecule that suppresses immune response under study in type 1 diabetes

... that hurts IDO expression. Dendritic cells, which can express IDO, show antigens to the T-cells. A Journal of Immunology paper last year reported that ... which causes dendritic cells to express IDO, at the same time they give antigens to the insulin-producing cells. "The presence of the antigen excites the T ...

Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis

... a methodology that allows us to detect minute traces of the TB antigens that are excreted in the urine by a TB-infected patient. What is so ... current sample collection, is completely non-invasive the presence of TB antigens in urine may be detectable earlier than through other samples, leading to ...

Children's National researchers develop novel anti-tumor vaccine

... stimulatory antigen loaded particles" (ISAPs), that consist of tumor antigens (proteins) from the specific tumor to be targeted, as well as immune ... then stimulate the immune system to specifically target the tumor whose antigens match those that are loaded in the particles known as tumor specific ...

From foe to friend: Researchers use salmonella as a way to administer vaccines in the body

... lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment," published on the online version (July ... serves as its own factory to produce (manufacture) the protective antigens (proteins) from the S. pneumoniae pathogen. This ability to cause ...

LIAI researchers discover new cellular mechanism that will significantly advance vaccine development

... makes a big difference. It narrows down the search for the right antigens tremendously." Scientists use knowledge of which antigens (virus pieces) trigger an antibody attack to develop vaccines. Vaccines ...

A protein sequence associated with Huntington’s disease may become life-saving vaccine component

... to a particular virus, bacteria or even cancer cells. Search for better antigens is one of the most pressing medical and public health necessities, and the biotech industry invests heavily in this research. However, antigens are able to generate a limited immune response if administered alone. In ...

Yale scientists create artificial 'cells' that boost the immune response to cancer

... covered in universal adaptor molecules that serve as attachment points for antigens molecules that activate the patients T-cells to recognize and fight off ... and efficient T-cell stimulation and proliferation in response to specific antigens is a goal of immunotherapy against infectious disease and cancer, said ...

ESF's workshop restores good name of sugar

... of antigens, alongside lipids (fatty compounds) and proteins. These antigens in effect determine the outcome of an infectious disease and the response by the host organism such as human - structural differences between these antigens often account for the inability of many diseases to cross from one animal ...

An 'attractive' man-machine interface

... attach to the mast-cell receptors by pre-coating them with antigens; these antigens then bound to antibodies that coated the receptors, similar to the way antibodies bind to antigens in the immune system. Our goal was to have one antigen coating each bead, ...

Immune police recognize good and bad guys in the body

... promotion may work for type 1 diabetes, they say. To determine what antigens Tregs can recognize, Drs. Pacholczyk and Ignatowicz did side-by-side ... Ignatowicz. We found regulatory cells respond to cells presenting non-self antigens as frequently as nave T cells. Researchers report that 70 percent of ...

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

... with metastatic melanoma whose disease had been minimized by other therapies. The study entitled "Phase II Trial of Dendritic Cells Loaded with antigens from Self-Renewing, Proliferating Autologous Tumor Cells as Patient-Specific Anti-Tumor Vaccines in Patients with Metastatic Melanoma," was published ...

American Chemical Society's Weekly PressPac -- May 20, 2009

... prevent the condition, the study says. ARTICLE #1 FOR IMMEDIATE RELEASE "Immunoproteomic Identification of Secretory and Subcellular Protein antigens and Functional Evaluation of the Secretome Fraction of Mycobacterium immunogenum, a Newly Recognized Species of the Mycobacterium chelonae ...

Gutsy germs succumb to baby broccoli

... assess colonization by H. pylori bacteria and blood tests to judge the severity of inflammation in the stomach lining; in addition, they looked for antigens in stool samples to help determine the extent of the infections. "We know that a dose of a couple ounces a day of broccoli sprouts is enough to ...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

... viruses and bacteria. Monoclonal antibodies are proteins crafted in a laboratory to recognize specific receptors, or antigens, on cancer cells; some antigens promote uncontrolled growth. These antibodies are designed to both attach to cancer receptors to inhibit their function and to alert and activate the ...

Shades of 1918? New study compares avian flu with a notorious killer from the past

... the host-pathogen responses to a common influenza virus and two ressortant strains of the 1918 H1N1 virus, each containing HA and NAkey surface antigens closely linked to the 1918 strain's potent virulence. The effects of these strains on host tissues and gene expression was compared with those of a ...

Immune cells reveal fancy footwork

... their sticky feet. This helps them to move much faster. Immature dendritic cells patrol the tissues in search of antigens. After exposure to such antigens they undergo a rigorous maturation process. During this maturation the dendritic cells migrate to the lymph nodes to activate T cells. Suzanne van ...

Research identifies type of vaccine that holds promise in protecting against TB

... However research in this area will continue as scientists test a similar recombinant BCG vaccine that expresses the same and additional key TB antigens that is expected to be even more potent than the one just studied and does not include the antibiotic resistant gene, Hoft said. "A new vaccine ...

Sensitive nanowire disease detectors made by Yale scientists

... for point-of-care (POC) disease detection, according to a report in Nano Letters . The sensors use activation of immune cells by highly specific antigens signatures of bacteria, viruses or cancer cells as the detector. When T cells are activated, they produce acid, and generate a tiny current in the ...

American Society for Microbiology honors Steven A. Rosenberg

... the development of interleukin-2 as the first effective immunotherapy for cancer, identification of more than two dozen human cancer associated antigens used in studies of cancer immunology and immunotherapy, identification of tumor infiltrating lymphocytes and the use of these cells in adoptive ...

FSU researcher using computers to hone cancer-fighting strategies

... effectiveness at killing the optimal number of cancer cells. *The rate at which immunotoxins bind with malignant cells and the relative amount of antigens expressed on the cell surface are especially critical factors, because an imbalance in those two factors may result in over-bombardment of a single ...

Footrot vaccine closer than ever

... response," Professor Rood said. "The approach, called reverse vaccinology, identified 90 proteins in the footrot bacterium that are potential antigens for a new cross-protective vaccine. This funding will allow us to pinpoint those proteins that will target the disease in a vaccine application," ...

Gene therapy protocol at UCSD activates immune system in patients with leukemia

... It also provides a much more specific target for antibody therapy. Antibodies that target ROR1 would be unlike currently used antibodies, which bind antigens found not only on leukemia cells, but also on normal cells. Because they can destroy normal cells, the antibodies currently used to treat patients ...

Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs

... found on the surface of white blood cells and other cells that play an important part in the body's immune response to foreign substances. These antigens vary from person to person, and an HLA compatibility test is performed before organ transplantation to find out if tissues match between a donor and ...

Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal

... Specifically, the technique allowed scientists to use antibodies to catalyze carbon-carbon bond formation and to bind catalytic antibodies to antigens covalently. (In general, antibodies bind non-covalently with their substrates.) "The key feature of the reactive immunization approach is that it ...

Why doesn't the immune system attack the small intestine?

... cells known as dendritic cells display the antigens of their normal neighbors in a way that puts the immune system "at ease." By reading those antigens without being on alert, the immune system's T ... serve the same purpose: exhibiting normal-cell antigens to the immune system. "Our study points to a ...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

... process required to isolate and clone the antigens for vaccine development. In working to ... of cancer. "Most of the cloned melanoma antigens that are known to target helper T cells are ... T cells. The old approach to cloning antigens adds an additional layer of complexity to the ...

Proteins anchor memories in our brain

... research showed that if just one of the body's antigens is not recognized as "self," this single failure ... treatments targeting individual body proteins or antigens since we have shown that a single self-antigen ... regulates the expression of some 300 to 1,000 antigens in the thymus. Humans and mice lacking the normal ...

Autoimmune disease triggered if T cells miss a single protein early on

... research showed that if just one of the body's antigens is not recognized as "self," this single failure ... treatments targeting individual body proteins or antigens since we have shown that a single self-antigen ... regulates the expression of some 300 to 1,000 antigens in the thymus. Humans and mice lacking the normal ...

Epstein-Barr virus might kick-start multiple sclerosis

... T-cell responses to influenza hemagglutinin, antigens derived from cytomegalovirus, and even EBV antigens other than EBNA1," Edwards said. "The T-cell ... CD4 cells directed against central nervous system antigens can trigger an MS-like disease," said Edwards. ...

Plant-derived vaccines safeguard against deadly plague

... also have the potential for the production of antigens that can be purified and delivered by typical ... "This new system produces really high levels of antigens in relatively short periods of time." The ... tobacco plants to make high levels of the plague antigens F1, V and a combination of the two, a so-called ...

'Underground' tunnels discovered as means for communication between immune system cells

... dendritic cells use this network to distribute antigens to other cells and it may be conceivable to ... macrophages, cells not normally picky about the antigens they engulf, were completely unresponsive to the ... a small number of dendritic cells with captured antigens to reach other dendritic cells in lymph nodes, ...

Protein splicing upsets the DNA colinearity paradigm

... recognize antigenic peptides displayed on the cell surface. The antigens are created by 'proteasomes,' components of the cell machinery that cut ... by the protein's DNA sequence template. This takes the possible number of antigens from any one protein into potentially thousands of sequence ....

Immune system police learn early and sometimes badly

... "The next question we will ask, which is a hot topic right now, is what antigens trigger receptors on regulatory T cells?" says Dr. Pacholczyk. "What do ... being generated is still a question. We want to look into the nature of antigens those receptors recognize which will allow us to predict more how they are ...

Genomics-based vaccine could prevent deadly cattle disease

... total, the team found five candidate vaccine antigens. In lab tests, these antigens triggered a response from cattle immune killer T cells. Going a further step further, the scientists inoculated cattle with these antigens and then gave the cattle a potentially lethal dose of T. parva . When ...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

... surface protein called a T-cell receptor, which recognizes only specific antigens (pieces of virus or bacteria that trigger the immune response). During an infection, CD8+ T cells that recognize antigens from the infecting pathogen are activated. These antigen-specific CD8+ T ...
Other Contents
(Date:10/14/2014)... study published in Cancer Research shows SIRT6—a ... colon cancers—can promote the development of skin cancers by ... survival of sun-damaged skin cells. , Previously considered protective, ... called sirtuins that help regulate genomic stability and prevent ... helps repair DNA damage, which can lead to cancer. ...
(Date:10/14/2014)... leading questions is how to produce enough food to ... Food and Agriculture Organization of the United Nations predicts ... 40 years to feed a growing global population, and ... in food production. Plants—grains, cereals, fruits, vegetables, and ... Current research must tap into our knowledge of how ...
(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
(Date:10/22/2014)... (PRWEB) October 22, 2014 Healthcare ... completing their continuing education at home or on-the-go ... access to 20 brand new, premium Seminar-on-Demand CE ... catalog of over 2,000 hours of ... customize their educational experience. With such a diverse ...
(Date:10/22/2014)... Lintelus, Inc., an event software provider, announced ... will be speaking on the subject of “Event Technology ... 28, at the Holiday Inn in New York City. ... as a Tech Demo at 12:45pm, to educate event ... engaging event experience. , The Annual Meetings Technology Expo ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, 2014 (HealthDay ... be showing a genetic propensity for obesity as toddlers, a ... linked to increased body fat, but the same genes in ... researchers said. At 1 year, kids with these genes ... however, these genes were linked to excessive weight gain, the ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... among young adult men may lead to increased blood pressure, ... cause a similar rise in blood pressure for young adult ... when young adult women drank lightly or moderately, their risk ... found. "This finding parallels studies in older adult men ...
(Date:10/22/2014)... Thompson HealthDay Reporter , MONDAY, ... Monday officially tightened guidelines for health workers treating Ebola patients, ... use of a respirator at all times. The U.S. ... tougher rules after two Dallas nurses contracted Ebola while caring ... Liberian national Thomas Eric Duncan. Nina Pham is currently being ...
Breaking Medicine News(10 mins):Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3
Other TagsOther Tags