Tracking influenza's every movement

... makeup of each virus. The team used this information to create an antigenic map which visually shows the relationships between all the different ... with the Santa Fe Institute, to develop the methods and software to build antigenic maps. This work is highly multidisciplinary, with epidemiologists, ...

7th annual [BC]2 Basel Computational Biology Conference 'Molecular Evolution' June 18-19, 2009

... including man. Derek Smith, Professor of Infectious Disease Informatics, Department of Zoology, University of Cambridge, UK, will present on "The antigenic evolution of influenza viruses". He will describe the study of influenza virus evolution, required for influenza vaccine strain selection. Derek is ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... stem, perhaps because it is less accessible than the head region. In this study, the scientists used recombinant purified protein, not virus, so the antigenic part of the virus recognized by the antibodies was fully exposed. Seasonal influenza occurs each year, causing mild to severe illness. Worldwide, ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... stem, perhaps because it is less accessible than the head region. In this study, the scientists used recombinant purified protein, not virus, so the antigenic part of the virus recognized by the antibodies was fully exposed. Seasonal influenza occurs each year, causing mild to severe illness. Worldwide, ...

American Society for Microbiology honors Eric Skaar

... in research in microbiology and infectious diseases. While a graduate student at Northwestern, Dr. Skaar focused on the molecular mechanisms of antigenic variation in the Gram-negative pathogen Neisseria gonorrhoeae. His research described novel systems used by N. gonorrhoeae to combat the oxidative ...

A protein sequence associated with Huntington’s disease may become life-saving vaccine component

... First, he noticed that small aggregates formed by an antigen fused to a polyQ tail resembled the droplets that conventional adjuvants formed with antigenic peptides exposed on their surface. Dr. Shneider hypothesized that these polyQ containing aggregates were easily taken up by antigen-presenting ...

Paracetamol, one of most used analgesics, could slow down bone growth

... process). Application of this plasma gel on bones accelerates their growth, without affecting other cell parameters such as the cell cycle or the antigenic profile. It is therefore an easy technique which involves few risks for the patient, who will recover from bone defects more quickly. Even ...

Protein splicing upsets the DNA colinearity paradigm

... function of 'antigen processing,' which produces antigenic peptides; the 'red flags' that mark cells for ... by another person - when T lymphocytes recognize antigenic peptides displayed on the cell surface. The ... that significantly extends the number of antigenic peptides that can be produced from a single ...

Breakthrough System for Understanding Ocean Plant Life Announced

... are somehow silenced. This genetic trick, called antigenic variation, has severely limited sleeping sickness ... role in the gene silencing process behind antigenic variation. With the goal of learning how the organism regulates the process of antigenic variation, the scientists have been trying to ...

Newly discovered protein an important tool for sleeping sickness research

... are somehow silenced. This genetic trick, called antigenic variation, has severely limited sleeping sickness ... role in the gene silencing process behind antigenic variation. With the goal of learning how the organism regulates the process of antigenic variation, the scientists have been trying to ...

Vaccine-producing 'plant-factories'

... cell. Some of these glycosylated recombinant proteins have significant antigenic power of great pharmaceutical interest. Conventional biotechnological ... large amounts of glycosylate recombinant proteins with significant antigenic power. By chance The new route discovered by the CSIC team ...

HIV exploits competition among T-cells

... form leads to a phenomenon known as deceptive imprinting, or original antigenic sin. Original antigenic sin is the tendency for memory immune cells produced in response to a ...

Simple idea to dramatically improve dengue vaccinations

... three viruses. "This is a classic case of something called 'original antigenic sin,' which happens when our immune system becomes overly reliant upon ... it had never been exposed to the disease in the first place." Original antigenic sin, or immunodominance, arises out of the procedure the immune system ...

Scientists to employ Arctic ice and polar bears to protect diversity of world's crops

... Scientists at St. Jude Children's Research Hospital have announced that a vaccine they developed a few years ago against one antigenic variant of the avian influenza virus H5N1 may protect humans against future variants of the virus. Vaccines based on this model might therefore be ...

H5N1 vaccine could be basis for life-saving stockpile

... Scientists at St. Jude Children's Research Hospital have announced that a vaccine they developed a few years ago against one antigenic variant of the avian influenza virus H5N1 may protect humans against future variants of the virus. Vaccines based on this model might therefore be ...

New factor implicated in allergy and asthma attacks

... species, and resulted in a much smaller increase in numbers of inflammatory immune cells. "We showed that you need both oxidative stress and antigenic exposure to get a robust allergy or asthma attack, and also that the first few minutes of the exposure are critical," Boldogh said. "The antigen ...

Breast tumors in mice eradicated using cancer vaccine

... of helper T cells, others survive by escaping into the cytosol of the cell. This is important because the antigen-processing pathway that feeds antigenic peptides to the surface of the cell for recognition by killer T cells is generated in this cellular compartment. "We reasoned that if we could get ...

Source of molecular triggers in cutaneous T cell lymphoma identified

... CTCL as a separate category of lymphoma thirty years ago. The Yale research group reported that, like all T cells, the cancerous CTCL cells require antigenic stimuli delivered by specialized dendritic cells of the epidermis, referred to as Langerhans cells (LC), in order to replicate. To determine the ...