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Antibody in Biological News

First human gets new antibody aimed at hepatitis C virus

... the safety and activity of a human monoclonal antibody they developed that can neutralize the Hepatitis ... virus (HCV). The first volunteer received the antibody known as MBL-HCV1 on July 28, 2009, and the study ... School. "This trial will test the safety of the antibody and measure its activity in the subjects. This ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... have successfully tested a small, engineered antibody they say shuts down growth of human glioblastoma ... Oncogene, the researchers demonstrate how this antibody latches onto a receptor that studs the outside of ... metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those ...

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

... can be overcome, by in-vitro enhancement of antibody production (termed- Stimmunology). The results, ... Institute of Technology, ran the same HIV antibody tests using both regular plasma and SMART-plasma ... than HIV" In summary, in-vitro enhancement of antibody production, made simple by the SMARTube, has been ...

A quicker, cheaper SARS virus detector -- one easily customizable for other targets

... epidemics. It consists of a piece of synthetic antibody attached to a nanowire that's attached to an ... base, immersed in liquid. If the protein the antibody binds to is present in the liquid, it will bind ... containing residues randomly distributed over the antibody surface." The Zhou lab, which has specialized ...

Princeton team's analysis of flu virus could lead to better vaccines

... this multi-stage interactive process -- known as antibody interference -- to advantage, the scientists ... Academy of Sciences . "We have proposed that antibody interference plays a major role in determining the effectiveness of the antibody response to a viral infection," said Ned ...

Novel antibody prevents infection by hepatitis C virus

... School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV). The new antibody effectively neutralized the virus in culture, and ... of pediatrics at the Medical School. "This antibody shows significant efficacy against the virus." ...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

... out like spikes from the viral membrane. But an antibody can only bind to two spikes at the same time if ... to stretch its two arms. "When both arms of an antibody are able to bind to a virus at the same time," ... as expected, that one-armed versions of the b12 antibody were less effective at neutralizing HIV than ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... stimulating ability of a fully human anti-PS antibody and the other demonstrates the ability of a second fully human anti-PS antibody to stimulate development of a critical component ... anti-PS pipeline. Peregrine's lead anti-PS antibody bavituximab is currently in Phase II clinical ...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

... DC - New research suggests that monoclonal antibody therapy of cancer can be improved to be much more ... 21 issue of the Lancet . "We believe that antibody therapy has the capacity to immunize people ... the last eight years of research on monoclonal antibody treatment, suggests that a new era in use of ...

A natural approach for HIV vaccine

... neutralizing activity, says Nussenzweig. But each antibody alone has limited ability to fight the virus. ... the virus in cell culture as well as any single antibody studied to date. These natural antibodies were ... diversity may be an advantage over a single super antibody that focuses on only one part of the virus, which ...

Twin nanoparticle shown effective at targeting, killing breast cancer cells

... On one end, they attached a synthetic protein antibody to the iron-oxide nanoparticle. On the other end, ... cell like a guided missile. The attached antibody is critical, because it binds to the antigen, a ... vehicle "docks" on the tumor cell when the antibody and the antigen become connected. Once docked, ...

Antibody key to treating variant CJD, scientists find

... of the 'binding' between a brain protein and an antibody that could be key to treating patients with ... To understand the 'connection' between the antibody and the protein, scientists at Liverpool used ... picture of the binding between an antibody called ICSM18 designed to 'stick' effectively to ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... In the study, the team of scientists used a human antibody phage display library to identify 10 mAb that ... were exposed to H5N1 virus. "Our human monoclonal antibody protected mice from the lethal H5N1 virus even ... can do this. What surprised us is that the same antibody protected mice from a lethal infection with a ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... In the study, the team of scientists used a human antibody phage display library to identify 10 mAb that ... were exposed to H5N1 virus. "Our human monoclonal antibody protected mice from the lethal H5N1 virus even ... can do this. What surprised us is that the same antibody protected mice from a lethal infection with a ...

UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology

... reduces the time required to sequence an unknown antibody to under 36 hours a "dramatic reduction" ... to verify the integrity and effectiveness of an antibody after the cell has undergone changes subsequent ... now, the only viable option for sequencing an antibody has been a process known as Edman degradation, ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... that a Phase 2 trial of an anti- C. difficile antibody combination treatment in patients with C. ... (p=0.0004 on the intent-to-treat population). The antibody combination treatment was generally safe and ... of Medarex. "We believe that the strength of our antibody technology platform for generating potentially ...

RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report

... found that infected mice treated with an anti-RSV antibody had less virus in the lungs and not only showed ... chronic phase of the disease. "If you use an antibody against RSV, you not only prevent acute disease ... a study in which we are treating kids with a new antibody that is very potent," she said. "The plan is to ...

Caltech biologists spy on the secret inner life of a cell

... of intestinal cells. FcRn snatches a maternal antibody molecule as it passes through a newborn's gut; the receptor and antibody are enclosed within a sac, called a vesicle, ... fused with the cell membrane and delivered the antibody cargo. The vesicles also appeared to include a ...

UT pathologists believe they have pinpointed Achilles heel of HIV

... attachment site to silence B lymphocytes - the antibody producing cells. The result is that the body is ... evolutionary implication of broadly neutralizing antibody fragments to HIV gp120 superantigenic epitope." ... "This is an entirely new finding. It is a novel antibody that appears to be very effective in killing the ...

Scripps research scientists reveal key structure from ebola virus

... entry into human cells, bound to an immune system antibody acting to neutralize the virus. The structure ... will have more to offer. The structure of the antibody together with the viral glycoprotein helps reveal ... The new research was made possible by an antibody isolated by Dennis Burton, a Scripps Research ...

LIAI researchers discover new cellular mechanism that will significantly advance vaccine development

... grew from the question, "why do you get good antibody responses to some parts of (virus) pathogens and ... on the paper, "Selective CD4 T cell help for antibody responses to a large viral pathogen: ... It was known previously that getting a good antibody response requires two different cells of the ...

Sugar linkage could lead to better treatment for autoimmune diseases

... anti-inflammatory activity to a glycoprotein antibody that could lead to improved treatment of ... around immunoglobulin G (IgG), the most abundant antibody in blood plasma. Intravenous immunoglobulin ... let the researchers engineer a synthetic human antibody that mimicked the linkages in IgG, providing an ...

MU researcher links hormone replacement therapy to breast cancer

... have compelling evidence that using an antibody that prevents new blood vessel formation in ... known as PRIMA, with similar properties as the antibody may be effective in treating or preventing the ... nourishment increases. However, when they used an antibody that inhibits the growth factor, the tumor ....

Bright lights: Mystery of glowing antibody solved by Scripps research scientists

... for diabetic patients. When the monoclonal antibody EP2-19G2 is combined with stilbene, a hydrocarbon ... Storm When EP2-19G2 binds stilbene, the antibody itself coordinates the joining or stacking of ... antibodies. Unlike in other complexes, this antibody reacts with stilbene in the excited ....

Is hybridoma production about to take a quantum leap forward?

... on the complete process of human monoclonal antibody production, and their results were published ... calculated that the secretion of monoclonal antibody in NPD-based media is roughly twice that obtained ... to stem-cell therapeutics, site-specific antibody treatments, and targeted anti-cancer drugs using ...

Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal

... 18, 2007 V For Immediate Release - A catalytic antibody discovery made at The Scripps Research Institute ... in the first quarter of 2008. The Catalytic antibody Advantage Empowered by compelling results in ... the amino acids within the active site of the antibody that would perform the chemical reaction," said ...

Cancer and arthritis therapy may be promising treatment for diabetes

... New Haven, Conn.An antibody used to treat certain cancers and rheumatoid ... Even better, the beneficial effects of the antibody continue to be observed long after the antibody is no longer administered, the researchers said. ...

Biotech Co. founded by UCLA Scientists to be acquired by Astellas, Pharma Inc.

... to tackle therapeutic, fully human monoclonal antibody oncology research and drug development. ... Dr. Aya Jakobovits, who helped develop monoclonal antibody technology at the company. Today, Agensys ... for a variety of cancer indications and in antibody product development, manufacturing and clinical ...

NIH selects LIAI for major study on allergy molecular causes and possible treatments

... field has been dominated by the analysis of the antibody response, because thats what causes many of the ... that the discovery of the immunoglobulin E (IgE) antibody in 1966 by Kimishige Ishizaka, M.D., Ph.D. and ... induce immune tolerance, without instigating an antibody reaction, Sette explained. If this proves true, ...

UV light improving chances of fighting cancer

... a process called cloaking. This prevents the antibody reacting within the body unless it is illuminated. When UV-A light is shone onto the cloaked antibody it is activated. The activated antibody binds to T-cells, the bodys own defence system, ...

West Nile virus' spread through nerve cells linked to serious complication

... back to the spinal cord. Unless you have a robust antibody response, you're probably not going to clear that ... When scientists injected a therapeutic antibody the day after the viral injection, it blocked ... clinical trials in humans. "We already knew the antibody could block encephalitis," notes Diamond, in ...

Reversing cognitive deficits: Injectable antibody may attack source of problem

... part of the immunoglobulin M (IgM) class -- is an antibody that grabs onto the amyloid beta protein in the ... in the right amount to treat illnesses. This antibody does that. Banks says the findings are surprising because IgM is five times bigger than the antibody immunoglobulin G (IgG), which has already been ...

MIT model could improve some drugs' effectiveness

... The model can predict structural changes in an antibody that will improve its effectiveness. The team ... Tidor. New and better methods for improving antibody development represent critical technologies for ... method can predict which changes in an antibody will make it work better, allowing chemists to ...

Mice stressed in simulated weightlessness show organ atrophy

... His long-term goal is to develop an OPN antibody a monoclonal or target-specific antibody that will inhibit OPN function in lab mice, and ultimately, in humans. This antibody could prove useful in treating the many ...

New cancer drug delivery system is effective and reversible

... cells, with limited success. A common approach involves attaching an antibody to the liposome membrane. Ideally the antibody will bind to a cancer cell receptor so that it can deliver the liposome ...

Penn-Wistar team gains insight into HIV vaccine failure

... These individuals were found to have high blood Ad5 neutralizing antibody (nAb) titers, the main immune gatekeeper in most vaccine strategies. ... activation or expansion of CD4 T-cells in either the high- or the low-Ad5 antibody groups. "It doesn't appear that vaccination increases the pool of ...

Virus-resistant grapevines

... the plant. Using simple routine processes, the researchers introduce the antibody gene into the bacteria, which then act as a transport vehicle and carry it ... their modified versions are up to 100 percent resistant to the virus. "The antibody is produced very effectively inside the plants," says Schillberg. "The ...

Another JDRF partner moves research forward with collaboration agreement for diabetes treatment

... which has joined with GlaxoSmithKline to develop an anti-CD3 antibody to preserve beta cell function in newly diagnosed patients; Maryland-based MacroGenics, which is developing a similar antibody with Lilly; and Canada's Transition Therapeutics, which has signed a ...

Epstein-Barr virus may be associated with progression of MS

... and three years later. Results showed that higher levels of anti-EBV antibody measured at the beginning of the study were associated with an increased ... with MS. The study will investigate the relationship of anti-EBV antibody levels to development of gray matter atrophy, neurocognitive function and ...

Tailor-made recombinant proteins in mammals

... turn it into a target for diagnostic imaging, for example, or convert an antibody into a drug that seeks out and attacks cancer cells, directing a chemical ... of these, and some lie near sites that, if modified, would cripple the antibody instead of making it therapeutic. Bertozzi's group proved they could ...
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(Date:9/22/2014)... areas of sea ice melt in the summer and when ... thinner and more reduced. As the Arctic summers are getting ... reduced sea ice in the Arctic will remove less CO2 ... are representative, then sea ice plays a greater role than ... global CO2 budgets", says Dorte Haubjerg Sgaard, PhD Fellow, Nordic ...
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