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Antibodies in Biological News

New cancer drug delivery system is effective and reversible

... cancer drug into the cell. Developing such antibodies is costly and time-consuming, however, and the ... them to liposomes is difficult to control. antibodies spur an immune response, requiring extra steps to ... agents, but those now in use are not as good as antibodies at binding to cancer cells. To solve the ...

Penn-Wistar team gains insight into HIV vaccine failure

... had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used to deliver ... immune gatekeeper in most vaccine strategies. antibodies produced in response to previous infection ... to indicate that pre-existing neutralizing antibodies correlated with numbers of activated CD4 T-cells ...

LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia

... National Institutes of Health to study whether antibodies that recognize carbohydrate (sugars) and proteins ... research by Dr. Kolls found that carbohydrate antibodies are part of the natural response to the ... Theses preliminary studies show that these antibodies participate in early clearance of the organism ...

UT scientist receives hemophilia research award

... resistant to replacement Factor VIII and produce antibodies that attack the synthetic protein. "Current therapies to treat these antibodies are expensive and often unsuccessful," Smith ... trigger the production of the anti-Factor VIII antibodies in people with Hemophilia A, which in turn would ...

Major breakthrough in early detection and prevention of AMD

... in the living eyes of mice by attaching anti-CCR3 antibodies to tiny semiconductor nanocrystals called "quantum dots" and injecting these into the mice. The antibodies cause the quantum dots to attach to CCR3 on the ... blood vessels in the eye. Thus the same anti-CCR3 antibodies used to detect CNV could potentially be useful as ...

Princeton team's analysis of flu virus could lead to better vaccines

... naturally produced defensive proteins called antibodies that fight infection. By manipulating this ... a human, the body mounts a defense, producing antibodies custom-designed to attach themselves to the ... noticed a perplexing pattern. He found that antibodies were often better at protecting against a ...

Novel antibody prevents infection by hepatitis C virus

... then painstakingly searched for individual human antibodies produced in the mice that would recognize and ... known as the glycoprotein. Once they found human antibodies that looked promising, they evaluated in vitro the ability of those antibodies to neutralize the virus and selected a lead ...

Avian flu research sheds light on swine flu outbreak

... HA surface protein, one of the sites where human antibodies created in response to current vaccines would ... against the virus. The immune system produces antibodies against the vaccine that remain in the system ... one is later introduced into the system, those antibodies attach to viral particles and remove them before ...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

... due to the fact that our body's natural HIV antibodies simply don't have a long enough reach to ... "This study helps to clarify the obstacles that antibodies face in blocking infection," says Pamela ... for HIV has proven so elusive." Y-shaped antibodies are best at neutralizing viruses--i.e., blocking ...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

... biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and serious virus ... to the observed anti-tumor activity of anti-PS antibodies in preclinical and clinical studies," said Dr. ... compelling evidence suggesting that PS-targeting antibodies facilitate an important cytokine shift in the ...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

... of these therapies, and have found that antibodies are capable of stimulating the immune system in ... we can now take advantage of," Weiner says. antibodies are immune system proteins that seek out and ... a body, such as viruses and bacteria. Monoclonal antibodies are proteins crafted in a laboratory to recognize ...

A natural approach for HIV vaccine

... before it takes hold. So far, these magic bullet antibodies have proved impossible to produce in people. Now, ... approach. They have identified a diverse team of antibodies in "slow-progressing" HIV patients whose ... shotgun approach using of a wide range of natural antibodies rather than an engineered magic bullet. "We ...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range of ... and some seasonal influenza viruses. These antibodies have the potential for use in combination with ... Nature Structural and Molecular Biology . The antibodies identified by the team of scientists neutralize a ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range of ... and some seasonal influenza viruses. These antibodies have the potential for use in combination with ... Nature Structural and Molecular Biology . The antibodies identified by the team of scientists neutralize a ...

Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection

... rejection. "The possibility that these antibodies can be used to treat diverse autoimmune diseases ... colleagues explain how they discovered that the antibodies produced by this patient blocked the sphingosine ... the researchers created more of the patient's antibodies in the laboratory and gave them to mice with ...

Evolution in action: Our antibodies take 'evolutionary leaps' to fight microbes

... with microbes by rearranging the genes that make antibodies to foreign invaders. This research fills a ... involves tailoring the genes that code for antibodies to specific viruses or bacteria. Researchers have ... once (cluster mutations) in the DNA, adapting our antibodies for a rapid and effective response to a new ...

Nature Medicine study shows Peregrine's bavituximab can cure lethal virus infections

... Agency (DTRA). Bavituximab and other anti-PS antibodies are also being studied preclinically in HIV, ... "Based on these findings, anti-PS antibodies such as bavituximab may represent a completely ... host cell rather than the virus itself, anti-PS antibodies have the potential to treat a range of viral ...

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

... (CDA-1) and MDX-1388 (CDB-1), two fully human antibodies that neutralize C. difficile toxins A and B, ... relapse indicates that treatment with monoclonal antibodies against the toxins could reduce this significant ... highlight the exquisite specificity of monoclonal antibodies and their important role to save lives," said ...

UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development

... for their ability to bind to pre-made monoclonal antibodies that are already known to neutralize all ... researchers will look for peptoids that bind to antibodies that recognize structural features shared by all ... to determine whether they can actually elicit antibodies that neutralize the pathogen. Dr. Vitetta said ...

Caltech biologists spy on the secret inner life of a cell

... PASADENA, Calif.-- The transportation of antibodies from a mother to her newborn child is vital for ... first time the complicated process by which these antibodies are shuttled from mother's milk, through her ... mammalian immune system. Newborns pick up the antibodies with the aid of a protein called the neonatal Fc ...

Statins may prevent miscarriages

... In this autoimmune syndrome, the body produces antibodies directed at phospholipids, the main components of ... and colleagues showed that antiphospholipid (aPL) antibodies in female mice caused inflammation that injured the placentas and induced abortions. These antibodies activate a protein, C5a, that activates another ...

Munich researchers discover key allergy gene

... of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is ... the immune system becomes biased and produces IgE antibodies against harmless agents such as pollen, dust mites or animal hair. These IgE antibodies then work in conjunction with certain cells to ...

Survivors of 1918 flu pandemic protected with a lifetime immunity to virus

... to the disease for the remaining of their lives. antibodies produced by cells isolated from these survivors ... 1918 infection. The study entitled "Neutralizing antibodies derived from the B cells of 1918 influenza ... and successfully isolated B cells that produce antibodies that block the viral infection," said ...

1918 flu antibodies resurrected from elderly survivors

... Children's Hospital at Vanderbilt have recovered antibodies to the virus from elderly survivors of the ... long-lasting immunity to such viruses, these antibodies could be effective treatments to have on hand if ... methods of making antibodies, to try to make antibodies to the 1918 flu, he was skeptical, but agreed to ...

Potatoes may hold key to Alzheimer's treatment

... (AD), and researchers have used that to develop antibodies that may slow or prevent the onset of AD. ... be a major AD contributor) to produce A antibodies can slow disease progression and improve ... found that the mice produced strong levels of antibodies that could attach to amyloid beta protein both in ...

NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008

... probable Alzheimer's disease tested positive for antibodies in their plasma against a type of bacteria that ... markers associated with Alzheimer's disease, antibodies to these periodontal bacteria could serve to ... bacterial booster, animals could produce more antibodies against the prion protein in the mouth and blood ...

UT pathologists believe they have pinpointed Achilles heel of HIV

... can ward off viruses by making proteins called antibodies that bind the virus. However, HIV is a constantly changing and mutating virus, and the antibodies produced after infection do not control disease ... vaccine that stimulates production of protective antibodies is available. The Achilles heel, a tiny ...

Researchers develop new ultrasensitive assay to detect most poisonous substance known

... The microscopic beads are coated with antibodies to the botulinum neurotoxin and then mixed with the liquefied sample to be tested. The antibodies latch on to any botulinum neurotoxin molecules ... are investigating the potential use of antibodies for different diseases to expand the scope of the ...

Presence of certain antibodies signals healthier teeth and gums

... Researchers discovered that the HtpG antibodies were present in much lower amounts in people with ... those with healthier teeth and gums. Typically, antibodies are elevated in people with disease, because they ... with periodontal disease have higher levels of antibodies to the bacteria associated with periodontal ...

Ugandan monkeys harbor evidence of infection with unknown poxvirus

... and cowpox. Most of the monkeys screened harbor antibodies to a virus that is similar but not identical to ... the virus. An initial screening for antibodies to the vaccinia virus yielded positive results in ... were surprised to find that the monkeys harbored antibodies to some, but not all, of the proteins associated ...

New technique yields more detailed picture of chromatin structure

... step in the imaging process: the use of tagged antibodies to label key components of the cells. These ... target is inside the condensed chromatin, the antibodies have no way to penetrate. Instead of fixing ... cells to the labeled antibodies. This allowed the antibodies to penetrate more deeply into the chromatin ...

Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find

... the growth of human tumors in a mouse model. antibodies are molecules produced by the body to help ward off infection. Natural and manmade antibodies work by latching onto very specific targets such ... are used as medications, such as insulin or antibodies used to treat some cancers, but because the ...

ETH Zurich researchers develop antibody test

... a specific immune reaction in adults. antibodies in blood from malaria regions Tests show that ... Africa where malaria is endemic contain specific antibodies against particular GPIs. While infection is still ... are infected with malaria, the number of antibodies increases significantly. Subsequently, there is a ...

Is hybridoma production about to take a quantum leap forward?

... to evaluate the use of fully human monoclonal antibodies as a complementary or primary therapeutic agent ... the efficient production of human monoclonal antibodies is a high priority. But any attempt to produce ... from the difficulty inherent in generating human antibodies against human tissues. The capacity to ...

Gene therapy protocol at UCSD activates immune system in patients with leukemia

... treated with a gene therapy protocol began making antibodies that reacted against their own leukemia cells. ... leukemia. Several of the patients started making antibodies that reacted against their own leukemia cells. When tested in the lab, the antibodies also reacted with the leukemia cells of other ...

HIV isolate from Kenya provides clues for vaccine design

... Although most people infected with HIV produce antibodies against the virus within several weeks following infection, these antibodies rarely prevent the infection from progressing to ... sensitivity to inactivation by a number of antibodies produced in people infected with HIV. The ...

Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal

... technology represents the first time catalytic antibodies have been used in human therapy. Building on ... system to the presence of the invaders, catalytic antibodies recognize the transition state for chemical reactions. Catalytic antibodies can also catalyze chemical reactions, similar to ...

Scripps research team blocks bacterial communication system to prevent deadly staph infections

... procedures, induces the production of antibodies by the immune system. The Janda group ... Next, the team isolated and studied the antibodies produced in mice injected with the hapten, called ... Subsequent experiments revealed that one of these antibodies in particular, when administered to mice infected ...

UV light improving chances of fighting cancer

... technology which uses UV light to activate antibodies which very specifically attack tumours. Therapeutic antibodies have long been recognised as having excellent ... University have developed a procedure to cloak antibodies which can then be activated by UV-A light and so ...

Yale chemist receives NIH Young Investigator Award for antibody targeting

... his work designing a rational approach for using antibodies to target a wide variety of cells and disease ... which he is exploring a novel approach to using antibodies that recognize a single small molecule as a ... in immunizations in order to generate anti-DNP antibodies as a test of the status of the immune system. ...
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(Date:8/21/2014)... LAWRENCE A study recently published in the journal ... Kansas shows a new role for the protein adenomatous ... second-leading cause of cancer-related deaths in the U.S. , ... of Molecular Biosciences and co-leader of the Cancer Biology ... better part of her career trying to understand the ...
(Date:8/21/2014)... A team of researchers at Louisiana Tech ... using affordable, consumer-grade 3D printers and materials ... contain antibacterial and chemotherapeutic compounds for targeted ... doctoral students and research faculty from Louisiana ... collaborated to create filament extruders that can ...
(Date:8/21/2014)... developed a novel and versatile modeling strategy to simulate ... materials as well as for studying polyelectrolytes, including DNA ... model much larger and more complex polyelectrolyte systems, and ... lead author of a paper on the work and ... Science and Engineering. "This is a big step forward ...
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