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Antibiotic in Biological News

Test helps in fight against lung infections and for treating other life-threatening infections

... system. Patients spend more time in hospitals, antibiotic costs and treatment costs increase as more ... shown very positive results in selecting proper antibiotic treatment for serious lung infections in patients ... bioFILM PA™ kit as guidance, an additional antibiotic not normally used in CF lung infections was ....

C. difficile spores spread superbug

... New research suggests that antibiotic treatment could be asymptomatically inducing the ... in hospitals, to include all patients receiving antibiotic treatment - although logistically complex - is ... in this case the mouse - primarily in response to antibiotic treatment but also in response to immune impaired ...

Plant microbe shares features with drug-resistant pathogen

... antibiotics in both strains. "This suggests that antibiotic resistance is part of the species' core genome, ... as a reservoir for opportunistic pathogens or antibiotic resistance genes. "This is something that should ... sp. 638, neither of which contain broad spectrum antibiotic resistance or virulence factors that would allow ...

SRI International receives $100,000 Grand Challenges Explorations grant

... Protein Biochemistry at CADRE, titled "Combating antibiotic Resistance in Tuberculosis." SRI's project is ... research project will address the problem of antibiotic resistance and the need for broad-spectrum ... of antibiotics. Since proteins that are antibiotic targets are prone to mutations that can result ...

Flies may spread drug-resistant bacteria from poultry operations

... food animal production and exposures to antibiotic resistant pathogens. Previous studies have linked antibiotic use in poultry production to antibiotic resistant bacteria in farm workers, consumer ...

Research uncovers promising target to treat chronic abdominal pain

... as well as normal mice that were treated with an antibiotic already known to generate extra EAAT2 in the ... the transgenic mice and mice treated with the antibiotic that increases EAAT2 experienced less pain than ... gone wrong in these patients," he said. The antibiotic ceftriaxone used in the study to increase EAAT2 ...

Duke software dramatically speeds enzyme design

... changes of a key enzyme that produces a natural antibiotic called gramicidin S, said Bruce Donald, Duke's ... enzyme system, which produces the natural antibiotic in Bacillus brevis bacteria. In the new PNAS ... gramicidin S is probably not a really useful antibiotic against emerging infectious diseases, it's a ...

Nanoemulsion potent against superbugs that kill cystic fibrosis patients

... that this technology works differently from antibiotic drugs, it provides a potential alternative for ... cystic fibrosis patients are receiving antibiotic treatments they inhale using a nebulizer, rather ... but resistance is still a major stumbling block. antibiotic resistance is a bigger problem now than it was ...

NYU scientists discover dangerous new method for bacterial toxin transfer

... of hospitals nationwide due to its growing antibiotic resistance, could co-opt viral parasites as ... species. Microbes have been known to gain antibiotic resistance through the transfer of plasmids, ... become major public health concerns after gaining antibiotic resistance through plasmids transferred from ...

Fewer deaths with preventive antibiotic use

... researchers compared the effect of two kinds of antibiotic treatments with the standard ICU care. They ... three days. One of the groups received an oral antibiotic paste four times a day. The second group, in ... reduced the number of deaths by 3.5 percent (oral antibiotic paste, and antibiotics in the intestinal tract ...

Escherichia coli bacteria transferring between humans and mountain gorillas

... bacteria, in gorillas, which implies that antibiotic resistant bacteria or resistance-conferring ... used appropriately as evidenced by high rates of antibiotic resistance in bacteria from people in rural ... face masks for people entering ape habitats. antibiotic resistance is an emerging problem in humans, and ...

Biomedical engineers' detective work reveals antibiotic mechanism

... the efficacy of older antibiotics and reveal new antibiotic targets within bacterial cells. "The research ... antibiotics. This lays the foundation for further antibiotic development -- a pressing drug development need." ... and off when they subjected E. coli bacteria to antibiotic treatment. Within the category of antibiotics ...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

... blood before and after two weeks of intravenous antibiotic therapy. The severe exacerbation and antibiotic therapy served as a condensed model of illness and response to therapy; in these cases antibiotic therapy is usually successful, and patients' ...

New antibiotic candidates from Braunschweig

... release is available in German . A group of antibiotic natural products discovered at the Helmholtz ... cells. Subsequently, the number of effective antibiotic targets in bacteria is severely limited; every ... many years ago we recognized their unusual antibiotic effect. It was directed in an unknown manner ...

Wielding microbe against microbe, beetle defends its food source

... What's more, the bacterium does so by wielding an antibiotic that is brand new to science. The isolation of ... What's interesting about the small molecule antibiotic it produces, though, is that it doesn't seem to ... allowing it to survive the same low doses of antibiotic that wipe out its competitor. This suggests ...

Milk may help bacteria survive against low levels of antibiotics

... structure protects them against host defences and antibiotic treatment, allowing the bacteria to persist in ... team is currently trying to identify the correct antibiotic concentrations needed to stop biofilms forming in ... the animals are cured quicker, we will have less antibiotic residue in the environment and the risk of ...

Rapid test for pathogens developed by K-State researchers

... set one pathogen apart from another and determine antibiotic resistance. Traditionally, it takes days and ... simultaneously looks for multiple diseases and antibiotic resistance, reducing the time it takes from ... means physicians and veterinarians often start antibiotic treatment before knowing exactly what they're up ...

New antibiotic beats superbugs at their own game

... these resistant cells. Never before has an antibiotic been tested this way. "In the history of antibiotic development, an antibiotic arrives on the scene, and sooner or later ...

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

... University researchers have discovered how an antibiotic works to modulate the activity of a ... of action of ceftriaxone, a third-generation antibiotic with neuroprotective properties, in glutamate ... of Biological Chemistry, suggest that this antibiotic or a similar drug may serve as a potential ...

Early treatment of stomach infection may prevent cancer

... to rest any question about whether and when - antibiotic treatment of H. pylori can eliminate or reduce ... benefit, Fox says, is the associated finding that antibiotic treatment also reduces the level of other ... . Findings in humans and mice now suggest that antibiotic treatment potentially changes gastric microbiota ...

UIC scientists discover how some bacteria survive antibiotics

... have discovered how some bacteria can survive antibiotic treatment by turning on resistance mechanisms ... have learned how to sense the presence of the antibiotic in the ribosomal tunnel, and in response, switch ... drug, Mankin said. The phenomenon of inducible antibiotic expression was known decades ago, but the ...

Unique fungal collection could hold key to future antibiotics

... will address the urgent need for bringing new antibiotic compounds to market. Since their discovery, ... has radically increased the necessity for new antibiotic discovery. As part of a three-year ... antibiotics. Although the first natural product antibiotic to be used clinically, penicillin, was isolated ...

Decoy makes sitting duck of superbugs

... a bacterium and delivering it with an existing antibiotic they can switch off antibiotic resistance. Together with technology transfer ... approval has dramatically declined. Faced with antibiotic resistance the pharmaceutical industry is ...

Manure management reduces levels of antibiotics and antibiotic resistance genes

... MADISON, WI, November 26, 2007- antibiotic resistance is a growing human health concern. ... contributes to the spread of antibiotics and antibiotic resistance genes (ARG), and if they can be ... more effective than LIM at increasing the rate of antibiotic dissipation, but it was not a significant factor ...

Drug dosages often incorrect for obese patients

... said. Thats a problem. It could lead not only to antibiotic failure but also an increase in antibiotic resistance, another serious issue. The problem ... function, other disease problems and the type of antibiotic or other drug. Adipose tissue, or body fat, ...

UCLA/VA partners with ASU to advance biosensor technology for urinary tract infections

... reliably identify a bacteria and its spectrum of antibiotic susceptibility to aid point-of-care diagnostics ... susceptibility test to rapidly select the best antibiotic for treatment. Our mission is to create a ... physicians must decide whether to prescribe antibiotic therapy and, if so, ...

U Alberta researcher in same group as Darwin and Hawking

... recognized for a body of research that centers on the identification of antibiotic peptides in bacteria. antibiotic peptides play an important role in food preservation and may have ...

Two-pronged model could help foil tough cystic fibrosis infections

... and toxic hallmark of the common genetic disease. Combining a mainstay antibiotic with drugs to deprive the bacteria of iron, which facilitates their ... that become increasingly drug resistant and damaging. Tobramycin, the antibiotic routinely used against the microbes, can control, but not efficiently ...

Research identifies type of vaccine that holds promise in protecting against TB

... tuberculosis. This vaccine will not be tested further because it uses an antibiotic resistant gene that scientists want to keep out of the environment. ... to be even more potent than the one just studied and does not include the antibiotic resistant gene, Hoft said. "A new vaccine theoretically could not only ...

Herbicide-resistant grape could revitalize Midwest wine industry

... in order to locate the cells that have the gene, another gene that's an antibiotic to Kanamycin is inserted as a marker. The cells are then placed onto a ... the normal cells die. The only ones that will live are the ones with the antibiotic marker which are also the cells that contain the 2, 4-D resistant gene. ...

Nanotechnology boosts war on superbugs

... array with mucopeptides from bacterial cell walls and found that as the antibiotic attaches itself, it generates a surface stress on the bacteria which can ... walls. This small change makes it approximately 1,000 times harder for the antibiotic to attach itself to the bug, leaving it much less able to disrupt the ...

Beetles get by with a little help from their friends

... that produces a unique, newly discovered antibiotic. Interestingly, the antibiotic inhibits the growth of a fast-growing competitor fungus but does not ... fungus and bacteria around the area where they will deposit the eggs. The antibiotic from the bacteria prevents growth of the fast-growing competitor fungus ...

New way to make malaria medicine also first step in finding new antibiotics

... He was interested in that process partly because some phosphonates have antibiotic properties. Recently, Metcalf and his lab successfully identified and ... about these pathways the better we can find unknown phosphonates with antibiotic properties," Metcalf said. His lab has developed a directed strategy ...

American Chemical Society's Weekly PressPac -- Sept. 3, 2008

... done on those ingredients, including studies on their ability to fight antibiotic resistant infections, the scientists say. To close that gap, ... destruction by other chemicals while allowing the release of a controlled antibiotic dose for an extended period of time. These features are key to the ...

Potential new drug target to fight tuberculosis identified

... NEW YORK (July 29, 2008) -- With antibiotic resistance on the rise, tuberculosis is emerging as a bigger global health ... the development of anti-infective agents that goes beyond the traditional antibiotic paradigm. "That's exactly what we sought to do in this research," he says. ...

Researchers analyze how new anti-MRSA abtibiotics function

... in the U.S. alone each year. Mobashery is a world-renowned expert in antibiotic resistance and enzyme inhibitors and he and his research team have long ... functioning of PBP 2a, but the closed form is responsible for the antibiotic resistance manifestations. When the protein interacts with the cell wall ...

2 University of Illinois researchers named HHMI investigators

... that have potential as antibiotics. He studies microbial agents that have antibiotic properties but which have so far not been developed for therapeutic use in ... National Institutes of Health to discover, engineer and produce a class of antibiotic agents. Van der Donk also is a member of a related research theme at ...

Turning on cell-cell communication wipes out staph biofilms

... medical implants. Encased in self-produced slime and highly resistant to antibiotic therapy and the body's own immune defenses, biofilm infections represent a ... The findings also may have implications for treating biofilms of emerging antibiotic resistant staph strains, including methicillin-resistant Staphylococcus ...

MRSA in hospital intensive care -- what's growing where?

... enough to identify individual strains of bacteria, and to spot particular antibiotic resistance genes, says Gemma Kay. Our findings so far, from routine ... which can worsen their condition, prolong their stay and require heavy antibiotic regimes, diverting significant resources from the hospital budget. To date ...

Breakthrough research turns the tide on water-borne pathogen

... inhibit Cryptosporidiums parasitic punch, paving the way for an effective antibiotic treatment. In all, scientists identified ten new compounds, four of which are better at fighting Cryptosporidium than the antibiotic paromomycin, the current gold standard for evaluating anticryptosporidial ...
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