HWI scientist first in world to unravel structure of key breast cancer target enzyme

... Estrogen is a female sex hormone and androgens are the male sex hormones. Regardless of gender, everyone has some percentage of both estrogens and androgens in their bodies. Each of the enzymes discussed ... chemical mechanism involved in the conversion of androgens to estrogens. He also will be working with ...

BioScience tip sheet, December 2008

... and Men (and Mosquitofish): Antiandrogens and androgens in the Environment. Andrew K. Hotchkiss, Gerald ... Jensen, Dalma Martinovic, and Leon E. Gray Jr. androgens are hormones essential to the formation of the ... reproductive tract in vertebrates. Environmental androgens have caused adverse effects in several fish ...

New prostate cancer research findings

... use of therapies designed to stop the production of testosterone and other androgens that fuel cancer cell growth. New research has now detected that ... directions for research into treatments to block the development of these androgens in cancer cells. (Embargoed until 6:00pm EDT October 11th) WHO: The ...

New medications show promise in treating drug-resistant prostate cancer

... new cases of prostate cancer are diagnosed each year in the United States. The male hormones testosterone and dihydrotestosterone -- also known as androgens -- spur the growth of prostate cells, and drugs that block the receptors for these hormones are the most common treatment for the disease in its ...

Sex hormones link to heart risk

... disease such as stroke or myocardial infarction". "We examined associations of circulating estrogens (estradiol and estrone) as well as androgens (testosterone and androstenedione) with major cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age 19 years), ...

Monitoring poisons in the environment -- a woolly matter

... of the sheep ?values for wool concentration of both lead and copper were significantly higher in male sheep, which has been linked to the effect of androgens on metabolism. Dr Sneddon comments, "Sheep wool evidently has potential as a bio-indicator of naturally occurring heavy metal concentrations in ...

Spike in testicular cancer is focus

... information on various major suspected risk factors, such as past medical history, history of hernia, venereal diseases, and any medication with androgens and other hormones. They will also examine lifetime occupational history, tobacco smoking, alcohol consumption and dietary information. “Recent ...

Sex chromosome genes influence aggression andmaternal behavior, say UVa researchers

... gene Sry on the male Y chromosome from other sex chromosome genes. The presence of Sry leads to the development of the testes and high levels of androgens in males, which is partly responsible for aggression. Sry was deleted from the Y chromosome and replaced by a transgenic copy. In their ...

Macrophage signaling may affect hormone resistance in prostate tumors

... cancer, according to a new study by researchers at the University of California, San Diego (UCSD) School of Medicine. Male hormones called androgens are essential for the physiological function and growth of the prostate gland, and anti-androgen treatment, which blocks the expression of androgen ...

Hyena mothers give their cubs a helpful dose of hormones

... State University's Kay Holekamp, together with her colleagues, spent almost 10 years sampling androgen levels from free-ranging hyenas in Kenya. androgens are hormones, such as testosterone, that control development of typically masculine characteristics like aggression, muscle development and sexual ...

Pain killer fights breast cancer by targeting key enzyme

... breast cancer. This form of breast cancer is the most common kind of breast cancer in postmenopausal women. Aromatase converts hormones called androgens into estrogens, such as the hormone estradiol. Estrogen is a powerful mitogen ?an agent that causes cells to divide, and too much estrogen can cause ...

Tamoxifen-like drug suggests new ways to selectively block estrogen

... move beyond 'designer estrogens,' to all sorts of small molecules that mimic the actions of various hormones," Greene said. "We could create designer androgens for prostate cancer, or designer glucocorticoids to treat inflammation." Since "the primary regulator of cofactor recruitment is receptor ...

Tendency to hair loss inherited from the mother

... which develops as a result of the genetic change is more stable and is not broken down so quickly. Both mechanisms can lead to the effect of the androgens becoming greater, which in turn brings about hair loss." The findings are also interesting for the aspect of how hair loss is inherited. The gene ...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

... of cancer found in American men, and approximately 29,000 men will die from prostate cancer this year. Many cases of prostate cancer depend on androgens like testosterone for tumor growth and cancer cell proliferation, said Dr. Knudsen, the study’s senior author. A common treatment for prostate cancer ...