Sticky protein helps reinforce fragile muscle membranes
... the team identified a protein called alpha
dystroglycan as the "glue" that binds muscle ... too few sugar groups are added to alpha
dystroglycan, leading to a version of the protein ... Choriomeningitis virus), which binds tightly to alpha
dystroglycan, also disrupts the basal lamina ...
Biolex presents Locteron US Phase 2a hepatitis C data at EASL
... Denmark. Locteron, controlled-release interferon alpha
2b, is designed to improve patient care by ...
Locteron is a controlled-release interferon alpha
designed to improve patient care in the treatment ... lack a controlled-release mechanism. Interferon alpha
serves as the foundation of current combination ...
Small male chimps use politics, rather than aggression, to lead the pack, U of Minnesota study says
... the biggest and most aggressive male claims the alpha
male role and gets his choice of food and ... looking at behaviors they used to compete for alpha
male status relative to their size. Analysis ... gain broad support.
The study focused on three alpha
males who reigned between 1989 and 2003. Frodo, ...
Potential therapy for congenital muscular dystrophy
... regenerative capacity in a mouse model for alpha
7 integrin congenital myopathy," appears in the ... patients with mutations in the adhesion molecule alpha
7 integrin experience delayed developmental ... There is currently no treatment or cure for alpha
7 integrin congenital myopathy.
Protein marker for schizophrenia risk
... a significant change. These were identified as alpha
defensins, proteins responsible for killing ... colleagues confirmed their findings by examining alpha
defensin levels in the blood of 21 twin pairs ... sets, both siblings had significantly elevated alpha
defensins as compared with a group of control ...
MIT finds key to avian flu in humans
... cells have glycan receptors classified as alpha
2-6; avian respiratory cells' glycan receptors are known as alpha
2-3. This classification is based on how the ... a genetic switch that allows the virus to bind to alpha
2-6 receptors instead ...
Humans and monkeys share Machiavellian intelligence
... political leaders use during the Renaissance.
males, who rule the 50 or so macaques in the ... They make sure they have lots of sex with the alpha
male to increase the chances he will protect ...
But while they have lots of sex with the alpha
male and make him think hes going to be the ...
Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
... Dr. Jin describes his discovery that the pur alpha
protein, which is necessary for neuronal function ... repeated CGG sequences bind and sequester the pur alpha
protein, the protein is not available for its ... The researchers also found that the pur alpha
protein bound to CGG repeats becomes part of ...
High blood pressure, low energy -- a recipe for heart failure
... a protein called estrogen-related receptor alpha
(ERR alpha), helps the heart keep up with ... colleagues report that mice born without any ERR alpha
developed symptoms of heart failure when their ... and of molecular biology and pharmacology.
sits in the nucleus of cells and senses how much ...
Arctic climate under greenhouse conditions in the Late Cretaceous
... the first seasonally resolved Cretaceous sedimentary record from the alpha
Ridge of the Arctic Ocean.
The scientists analysed the remains of ... US and Canadian expeditions that occupied floating ice islands above the alpha
Ridge of the Arctic Ocean, recovered cores containing shallow buried upper ...
TRAPping proteins that work together inside living cells
... No one knew if this tail -- also known as the C-terminus of the alpha
subunit -- touches anything else in the core of the RNA polymerase ... another core protein called the beta subunit, suggesting the tail of the alpha
subunit makes contact with the beta subunit as it plugs along. This ...
'New' estrogen receptor found to be key player in tamoxifen resistance
... as resistance develops over time, breast cancer cells gradually lose the alpha
receptors while gaining the estrogen-related receptor gamma subtype.
The ... possible that tamoxifen is activating this receptor, " Riggins says.
estrogen receptors can be used as a drug target, then perhaps the gamma ...
Laminin builds the neuromuscular synapse
... of the nerve terminal. The team has now found evidence that the alpha
chains of laminin influence post-synaptic patterning. For example, ... to signals from the nerve. Overall, the work suggests that the beta and alpha
chains of laminin together influence pre-synaptic and post-synaptic ...
Ceramic, heal thyself
... into the seat."
Next, the scientists simulated an atom undergoing alpha
decay. An alpha
particle shoots out of the atomic nucleus with such force that the ...
Lipoic acid could reduce atherosclerosis, weight gain
... during the next five years with Oregon Health and Science University.
lipoic acid is a naturally occurring nutrient found at low levels in green ... a heart attack or stroke.
Researchers now believe that high levels of alpha
lipoic acid can be particularly useful in preventing this process, by ...
Safe water: simpler method for analyzing radium in water samples cuts testing time
... ended with a complicated final preparation step before measurement with an alpha
scintillation detection system. The scintillation detector detects and ... deadline requiring every water supply be tested for radium-228 and gross alpha
radioactivity greatly increased the number of radium-228 measurements ...
Navigating in the ocean of molecules
... Novartis pharmaceutical concern. 5-lipoxygenase is a target protein in the treatment of inflammation and bladder cancer, while the oestrogen receptor alpha
is an important starting point in the treatment of breast cancer.
"Scaffold Hunter is a key technological tool with innumerable possible ...
Protein regulates movement of mitochondria in brain cells
... regulator (HUMMR), is produced in a state of low oxygen called hypoxia. HUMMR is induced by another protein called hypoxic inducible factor 1 alpha
(HIF-1) which is responsible for triggering several processes in the cell that help it function in a low oxygen environment.
The primary role of ...
Protein linked to change in tissue that surround and support breast tumors
... portion of breast cancers.
Previous research at GUMC has found that AIB1 acts as a co-activator of growth proteins, such as estrogen receptor alpha
and HER2/neu, which are also often over-expressed in tumor development. "AIB1 and its more active variant potentiate both estrogen and HER2/Neu at ...
NSF announces funding for Alaska Region Research Vessel
... Vessel was designed in 2004 by The Glosten Associates, a group of marine architects located in Seattle. It was developed as a replacement for the R/V alpha
Helix, a 133-foot research vessel that was built in 1966 and retired and sold in 2007.
UAB professor receives HudsonAlpha Innovation Prize
Funding for the annual HudsonAlpha Prize for Outstanding Innovation in Life Sciences is provided through a grant by the alpha
UT Public Health researchers find link to severe Staph infections
"Immunity directed against LukS was more efficient in protecting mice against a USA300 infection compared to mice vaccinated with LukF-PV or alpha
toxin," Brown said. His research found that LukS-PV was effective at protecting against certain types of infections reinforcing the importance of ...
Master gene plays key role in blood sugar levels
... in collaboration with researchers from Duke University Medical Center in Durham, N.C., revealed that SRC-2 works with an orphan nuclear receptor ROR alpha
to affect the activity of the sugar-converting enzyme, glucose-6-phosphatase in the liver.
The liver produces 90 percent of the glucose ...
Musculoskeletal center wins $2.2 million for drug safety
... of eight biologics used for a range of autoimmune disorders. Among the studied drugs is what's called anti-TNF agents, or anti-tumor necrosis factor alpha
agents. This category includes adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade). Five additional biologics will be studied.
Major source of radon exposure overlooked at former Ohio uranium-processing plant
... in the range of underground uranium miners."
"When the plant was in operation, employees wore badges to measure gamma radiation exposurebut not alpha
radiation sources like radon," he adds.
According to company records, 7,143 people worked at the uranium processing plant between 1952 and the ...
Resveratrol prevents fat accumulation in livers of 'alcoholic' mice
Reduction of sterol regulatory element binding protein (SREBP-1)
Activation of peroxisome proliferator-activated receptor gamma co-activator alpha
Elevation of circulating adiponectin, a hormone produced by fat cells, which helps control obesity
Enhanced expression of ...
Egalitarian revolution in the Pleistocene?
... particular place in the existing dominance hierarchy. A major function of coalitions in apes is to maintain or change the dominance ranking. When an alpha
male is well established, he usually can intimidate any hostile coalition or the entire community.
In sharp contrast, most known hunter-gatherer ...
Munich researchers discover key allergy gene
... using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Mnchen.
The newly discovered FCER1A gene encodes the alpha
chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger ...
Extinction most likely for rare trees in the Amazon rainforest
... characteristics of tropical forests is the presence of very rare tree species. Competing models of relative species abundance, one based on Fisher's alpha
statistic and the other based on Preston's lognormal curve, yield different proportions of rare trees in the forest.
Thirty years ago Stephen P. ...
Improved estrogen reception may sharpen fuzzy memory
... at the cellular, synaptic and behavioral levels is a scientific tour de force which provides a strong foundation for the role of estrogen receptor alpha
in mediating estrogen action in the hippocampus to restore select types of memory function," said Roberta Diaz Brinton, Ph.D., a professor of ...
CO2 increase in the atmosphere augments tolerance of barley to salinity
... water) and absorbs less toxic ions and is better protected against oxidation.
Dr. Prez-Lpez selected two varieties of barley ( Hordeum vulgare cv alpha
and Hordeum vulgare cv Iranis ) and studied their development, their nutritional and hydric states, their antioxidant system and carbon and ...
Clumps of red and white blood cells may contribute to sickle cell disease
... patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin alpha
four beta one.
First author Julia E. Brittain, Ph.D., a research assistant professor in the medical schools department of biochemistry and ...
First draft of transgenic papaya genome yields many fruits
... ago, Ming said. Arabidopsis underwent two duplications of its entire genome in its recent evolutionary past, he said. These duplications, called alpha
and beta, are not shared by papaya or grape. A much earlier triplication of the genome, called gamma, that is estimated to have occurred some 120 ...
Key 'impact hunters' catalyze hunting among male chimpanzees
... what special qualities these chimpanzees might posses that would contribute to their role in hunting groups. Of the two impact hunters one was the alpha
male, but one was not particularly high-ranking or outstanding in terms of physical appearance. What appears to be significant is that these ...
Preventing tuberculosis reactivation
... publishing in PLoS Computational Biology, conducts virtual clinical trials to examine the causes of reactivation.
Tumor necrosis factor alpha
(TNF) is a protein that facilitates cellcell communication during an inflammatory immune response. Animal models have shown that TNF is vital for ...
After drought, ponds keep up with the Joneses
Chases findings are important to the study of biodiversity because he analyzed ponds both locally and regionally. A local analysis measures alpha
diversity, which is the analysis of all the species in one pond. Chase, on the other hand, measured beta diversity, which measures the difference ...
Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
... The cause of UC is not known and there is no cure.
REMICADE is the global market leader among anti-tumor necrosis factor alpha
(TNF-alpha) therapies and is the only anti-TNF-alpha treatment approved in three different therapeutic areas: gastroenterology, rheumatology and ...
Male contraception breakthroughs to be presented, Seattle Sept. 27-28
Here is a sample of the news to be announced at the conference:
a new compound that can be taken orally (Columbia University, Retinoic acid alpha
3-month and 6-month results in men for the Intra Vas Device, a vasectomy alternative (Shepherd Medical Company)
Same-sex mating by fungi spawned infection outbreak, evidence suggests
... can undergo same-sex mating between two alpha
Among clinical and environmental ... Heitman added. In a traditional sexual cycle, all alpha
progeny inherit identical alpha
genes from ...