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Affinity in Biological News

Study reveals specific gene in adolescent men with delinquent peers

... statistically significant association between an affinity for antisocial peer groups and a particular ... and warmth) showed no statistically relevant affinity for antisocial friends. "Our research has ... his colleagues found no statistically significant affinity for antisocial peers, regardless of whether the ...

Hemoglobin uncovered

... knowledge of the mechanisms that regulate the affinity of hemoglobin, which is crucial to understand, ... how, against what was commonly accepted, the affinity for oxygen appears to be controlled by ... Having identified the factors that regulate the affinity of hemoglobin, alterations of its structure can ...

MIT model could improve some drugs' effectiveness

... to treat colorectal cancer, that binds to its target with 10 times greater affinity than the original molecule. The work, which will appear Sept. 23 in an ... antibody variants and conformations, and predict the molecules' binding affinity for their targets based on the interactions that occur between atoms. ...

Study explains potential failure of oral contraceptives with obese women

... "lipophilic," or tend to concentrate in fat tissue. However, the researchers in this study said they were somewhat surprised to find that the affinity of these drugs for fat tissue was not significantly different between obese and normal body weight subjects. Rather, the researchers found that ...

Biologist discovers pink-winged moth in Chiracahua Mountains

... of the noctuid family, which often are dull colored. Walsh's moth, in contrast, is bright pink. He also named it after his wife, Lee, who has an affinity for the color. Walsh discovered L. leeae while collecting one evening at Onion Saddle, at about 7,700 feet in the Chiracahuas. Collecting ...

American Society for Microbiology honors George Liu

... graduate work was the investigation of the mechanism of immunologic tolerance in a model of autoimmunity. His novel concept that the low affinity of certain autoantigenic peptides could provide a basis for the existence of autoreactive T cells in humanshad an impact on the field of ...

Skin color clue to nicotine dependence

... Americans," said Gary King, professor of biobehavioral health, Penn State. King states that previous research shows that nicotine has a biochemical affinity for melanin. Conceivably, this association could result in an accumulation of the addictive agent in melanin-containing tissues of smokers with ...

Red pandas reveal an unexpected (artificial) sweet tooth

... Monell Center report that the red panda is the first non-primate mammal to display a liking for the artificial sweetener aspartame. This unexpected affinity for an artificial sweetener may reflect structural variation in the red panda's sweet taste receptor. The findings may shed light on how taste ...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

... with which the velcro-like protein Chp1 binds to methylated chromatin. "We found that a part of Chp1 known as the chromodomain binds with high affinity (or strength) to methylated chromatin," explains Thomas Schalch, Ph.D., a postdoctoral researcher in the Joshua-Tor lab who led the current study. By ...

New method for detection of phosphoproteins reveals regulator of melanoma invasion

... extracellular matrix environment. "Our results revealed successful selection and sequencing of phosphopeptides in proteolytic digests without affinity enrichment, as well as label-free quantitation of regulated protein phosphorylation events," concludes Dr. Ahn. "Further, we demonstrated ...

Magnetic nano-'shepherds' organize cells

... May publication of Nano Letters , a journal published by the American Chemical Society. "The cells have receptors on their surfaces that have an affinity for other cells," Krebs said. "They become sticky and attach to each other. When endothelial cells get together in a linear fashion, as they did in ...

AGU journal highlights -- March 25, 2009

... process that allows them to absorb water, potentially transforming particles into cloud condensation nuclei. To learn more about how soot develops an affinity for water, Khalizov et al. examine the properties of soot aerosols exposed to gaseous sulfuric acid. They find that although fresh soot does not ...

New drug agent knocks out multiple enzymes in cancer pathway

... also killed tumor cells in mice. And Socrates Papapoulos, of Leiden University, the Netherlands, showed that the compound had a very low chemical affinity for bone. In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells ...

Shifts in soil bacterial populations linked to wetland restoration success

... "We found that one of the simplest and most promising indicators of restoration success was the ratio of Proteobacteria, which have the highest affinity for nutrient-rich environments, to Acidobacteria, which have the highest tolerance for poor conditions," Hartman said. The researchers determined ...

Munich researchers discover key allergy gene

... technologies for examining the whole human genome at the Helmholtz Zentrum Mnchen. The newly discovered FCER1A gene encodes the alpha chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the Technische ...

News tips from the Journal of Neuroscience

... greater dopamine efflux under both basal and depolarized conditions, due to a greater sensitivity to intracellular sodium concentration and a higher affinity for intracellular dopamine. A role for increased dopamine efflux in ADHD was unexpected, because a common treatment for the disease is amphetamine, ...

UC San Diego researchers identify potential new drug candidates to combat 'bird flu'

... clinical trials. The results were intriguing. About 27 compounds showed significant promise, all having potentially the same or stronger bonding affinity than current anti-flu drugs now available, including Tamiflu and Relenza. Several looked like particularly good candidates, Amaro said, since they ...

Scientists reveal the key mechanisms for affinity between transient binding proteins

... in Spanish . Most of the functions performed by a cell are the result of interactions between proteins, which recognise their binding partner by affinity features localized on the protein surface. There are many kinds of interactions; however, the most complicated to study from the perspective of ...

Researchers coat titanium with polymer to improve integration of joint replacements

... arginine-glycine-aspartic acid (RGD) that binds to integrins. However, this region alone binds many different integrin receptors and with much less affinity than the full fibronectin protein. "It has been common to mimic only very small sections of fibronectin, but when you take a small section and ...

Nanotubes could help study retrovirus transmission between human cells

... membranes into tubes. Working with Sandia researcher George Bachand, she serendipitously found that interaction of the POPC membrane with a high affinity protein called streptavidin alone was enough to form the nanotubes. "Perhaps this information linking membrane bending energy with nanotube ...

Arbor Vita rapid H5N1 flu diagnostic presented at ICEID meeting

... the C-terminal region of the NS1 protein. As the C-terminal region of the NS1 protein differs for each influenza sub-type, a PDZ protein with high affinity to NS1 protein of H5 strains was chosen for assay development. The format of the developed assay is the familiar lateral-flow rapid antigen assay. ...

A fossilized giant rhino bone questions the isolation of Anatolia, 25 million years ago

... On the other hand, this discovery also tends to confirm that there was indeed a separation from Africa, as to date no species of African affinity has been found in the Oligocene soils of Anatolia. ...

Stowers Proteomics Center devises method for assigning probabilities to human protein interactions

... The Stowers Institutes Proteomics Center has published a novel method of using normalized spectral counts derived from a series of affinity purifications analyzed by mass spectrometry (APMS) to generate a probabilistic measure of the preference of proteins to associate with one another. ...

New genus of self-destructive palm found in Madagascar

... Botanic Gardens Kew, the details of the flowers and inflorescence branches immediately suggested it was a new, undescribed species and genus with an affinity to the palm tribe Chuniophoeniceae. Leaf fragments were sent to the Jodrell laboratory at the Royal Botanic Gardens, Kew for DNA analysis, where ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Abnormal Formation and Remodeling of Fibers Containing Type I Collagen Homotrimers. Pengying Hao, Wellesley College, Metal Ion Selectivity and affinity of the LIN-12/Notch-Repeat. Sarah K. Higgins, University of North Carolina Wilmington, A Synthetic Variant of Cecropin A is Significantly More ...

Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal

... but that these projects had all run up against the same roadblock. While potential therapeutics bound to the cancer integrin molecules with high affinity and specificity, the compounds were quickly cleared from the bodyXin some cases, in as short a period as 15 minutes. Especially for a chronic ...

MIT: 'Micro' livers could aid drug screening

... to those of fresh liver cells, giving us confidence that other [liver] functions are preserved, said Khetani. For drug testing purposes, this affinity to the human liver allows each colony to provide a window into the human livers response to a drug without having to expose human patients to the ...

Green alga genome project catalogs carbon capture machinery

... of these genes are normally associated with animals, such as those that describe the circuitry for flagella, enabling this alga to swim. Others have affinity with the earth's early photosynthetic organisms, cyanobacteria, dating far back into Precambrian times, more than three billion years ago, when ...

New technique helps researchers determine amino-acid charge

... the effect of the protein microenvironment on the affinity of ionizable amino-acid residues for protons. ... upon releasing them. "One thing is the proton affinity of an amino-acid residue when the amino acid is ... in, say, a glass beaker; another thing is the affinity for protons in the complex microenvironment ...

First technology to remove prions that cause vCJD from blood launched

... Council of Europe (CE) marking of its Leukotrap® affinity Prion Reduction Filter System. It is the first ... protection." Prion Protection The Leukotrap affinity Prion Reduction Filter removes all types of ... Pall Corporation developed the Leukotrap affinity Prion filter to help blood authorities around the ...

Scientists develope a new model of artificial canine skin

... Autònoma de Barcelona, in cooperation with the animal nutrition company affinity Petcare, have developed an artificial cellular model which faithfully ... cell cultures. Researchers at the UAB and UNIVET, in cooperation with affinity Petcare, have developed an artificial canine skin model, very similar to ...

New antifreeze protein found in fleas may allow longer storage of transplant organs

... the Queen's University Biological Station." Using a process called ice affinity purification, the team isolated the new protein, which is rich in an amino ... while other proteins are excluded," says Dr. Davies. "We use their affinity for ice as a tool to purify the protein." The antifreeze mechanism of ...

New results validating Pall prion reduction filter disclosed at ISBT Congress

... new research results further validating the performance of its Leukotrap® affinity Prion Reduction Filter System, which was CE marked with a 99.9 percent ... new research results that further support the performance of the Leukotrap affinity Prion Reduction Filter System. The study, conducted with the Departments ...

Scientists learn the origin of rogue B cells

... from the cutting and splicing of immunoglobulin genes early in B-cell development, and have the potential to develop strong and highly specific affinity for different pathogens. When an infectious pathogen (a disease-causing agent) enters the body, B cells are activated and release antibodies into the ...

Hofmeyr skull supports the 'Out of Africa' theory

... the South African fossil. Instead, the Hofmeyr skull is quite distinct from recent sub-Saharan Africans, including the Khoe-San, and has a very close affinity with the European Upper Paleolithic specimens. The field of paleoanthropology is known for its hotly contested debates, and one that has raged ...

In drug design, a loose fit may be best bet

... retaining most of the properties of the natural hormone. Measuring the cellular response when hormone meets receptor, they found that the lower the affinity between the two, the stronger the signal that is elicited, with certain analogs performing up to twice as effectively as TRH. As to why this would be ...

Natural vitamin E tocotrienol reaches blood at protective levels

... very well. "Our results demonstrate that TCT is efficiently delivered to the bloodstream despite the fact that the transfer protein has a lower affinity for TCT than it has for TCP," Sen said. Absorption of TCT is increased when the supplement is taken with fat-containing food, so the research ...

Finding paves way for better treatment of autoimmune disease

... A signaling molecule with an affinity for alcohol has yielded a rapid, inexpensive way to make large numbers of immune cells that work like beat cops keeping misguided cells from ...

UF scientists test improved gene therapy method for hereditary heart conditions

... easily passes into the heart muscle in primates after a single intravenous injection, and the effects are long lasting. "AAV-9 had a particular affinity for heart muscle that AAV-8 didn't," Byrne said. "Right now AAV-9 seems to be our best solution for heart problems. "The primates were done to ...
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(Date:7/28/2014)... adults suffer from fertility problems, many of these due ... We might expect such genes, which reduce an individual,s ... at the Weizmann Institute of Science that recently appeared ... this riddle. Not only can it explain the high ... avenues in understanding the causes of genetic diseases and ...
(Date:7/28/2014)... tools to map social connections in prairie dogs ... shedding light on prairie dog communities that may ... guide future conservation efforts. The work was done ... the National Evolutionary Synthesis Center (NESCent). , "Prairie ... bubonic plague," says Dr. Jennifer Verdolin, lead author ...
(Date:7/27/2014)... has revealed that nicotine and cotinine, a metabolite of ... certain carcinogen in smoke. , The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or ... and ultimately ends up in the tobacco smoke. Once ... where it is activated by a variety of enzymes ... revealed that nicotine can partially interfere with the activation ...
Breaking Biology News(10 mins):Mutations from Venus, mutations from Mars 2Social network research may boost prairie dog conservation efforts 2Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2
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