DuoCort: New chronotherapy for adrenal insufficiency
... I study for the rare and life threatening disease adrenal
insufficiency. The release profile of DuoCorts ... allowing it to be safely used in patients with adrenal
insufficiency. Data from a subsequent phase II/III trial in patients with primary adrenal
insufficiency or Addisons disease, presented at a ...
Stress puts double whammy on reproductive system, fertility
... - stress hormones - produced by the adrenal
gland. In the brain, these glucocorticoids ... the role of glucocorticoids, Kirby removed the adrenal
glands of male rats, eliminating the source of ... for glucocorticoids, which are released from the adrenal
glands in response to stress, and that removal of ...
Simple drug treatment may prevent nicotine-induced SIDS: Study
... called catecholaminesfrom the adrenal
glands. During birth, these hormones in turn ...
For some months after birth, the adrenal
glands act as a critical oxygen sensor. A drop in ... back," explains Buttigieg. "In this case, the adrenal
glands do not release catecholamines during ...
New research explains link between smoking and SIDS
... catecholaminesa group of hormones released by the adrenal
glandsplay in a babys transition to the outside ... baby is exposed to low oxygen, which signals the adrenal
glands to release the catecholamines, which ... efficiently. And for some months after birth, the adrenal
gland still acts as an oxygen sensor, aiding in ...
Hormone levels contribute to stress resilience
... military Combat Diver Qualification Course (CDQC).
Dehydroepiandrosterone, or "DHEA" as it is commonly known, is a hormone that is secreted by the adrenal
gland in response to stress. Although medical scientists have known for over a decade that DHEA provides beneficial, anti-stress effects in animals, ...
Genetic finding could lead to targeted therapy for neuroblastoma
... to tumorigenesis (tumor formation) of neuroblastoma."
Neuroblastoma forms in developing nerve cells, with tumors most often found on a child's adrenal
gland. It's the most common form of cancer in babies and the third most common childhood cancer, according to the American Cancer Society.
Led by ...
New discovery paves the way for new diagnosis of serious lung disease
... Patients with this disease are afflicted by the immune system erroneously attacking several tissues, such as the liver, insulin-producing cells, and adrenal
"Only now have we understood that the lungs are attacked as well and that in many cases this is the most serious component of the disease ...
Many African-Americans have a gene that prolongs life after heart failure
... the response to adrenaline and similar hormonal substances that increase how hard the heart works. Adrenaline is a hormone released from the adrenal
glands that prompts the "fight-or-flight" response it increases cardiac output to give a sudden burst of energy.
In heart failure, decreased ...
Family conditions may affect when girls experience puberty
... both mothers and fathers. The study followed the children through middle school, testing the first hormonal changes of pubertythe awakening of the adrenal
glandsin 120 of the children (73 or whom were girls) when they were in first grade, and the development of secondary sexual characteristicssuch as ...
Understanding hypertension in African Americans proves elusive
... but too much of it can contribute to the development of hypertension because it causes the kidney to retain salt. Aldosterone, released by the adrenal
glands on top of the kidneys, plays a role in the complex system used by the body to regulate blood pressure.
Although the results are ...
3-D ultrasound identifies women at risk for impending preterm birth
... ultrasound was used to measure the size of fetal adrenal
glands, according to an abstract presented by ...
"Our results suggest that examining the fetal adrenal
gland at the time a woman is evaluated for ... high accuracy, sensitivity and specificity of the adrenal
gland volume in predicting preterm birth within ...
Scientists unravel clue in cortisol production
... When a person's under stress or injured, the adrenal
gland releases cortisol to help restore the ... when the hypothalamus sends a signal to the adrenal
glands. Proteins then flood into the nucleus to ... decided to model the events that occur after the adrenal
gland receives the signal.
One of the things ...
Lack of key enzyme associated with development of rare tumor
... Health have discovered that a rare tumor of the adrenal
glands appears to result from a genetic ... in collecting samples from patients with rare adrenal
disorders. Scientists from Sapio Sciences in ... the DNA of patients with a rare tumor of the adrenal
glands, known as micronodular adrenocortical ...
Researchers find docking sites for glucocorticoid receptor and Hsp90
... University of Oregon.
Glucocorticoids are naturally produced by the adrenal
glands and are important for a variety of tissue-related activities. They ... and anti-inflammatory, and are prescribed for such conditions as adrenal
insufficiency as in Addison's disease, arthritis, asthma, inflammatory ...
Stress may help cancer cells resist treatment, research shows
... on-line in the Journal of Biological Chemistry and will appear in a future print issue.
Levels of epinephrine, which is produced by the adrenal
glands, are sharply increased in response to stressful situations and can remain continuously elevated during persistent stress and depression, ...
Twin studies reveal genetic components leading to cardiac and kidney disease
... Release of one of these markers, called endothelin (ET-1), is trigged by a gene that regulates catecholamines, chemical compounds produced in the adrenal
gland that are released in reaction to stress. The study measured the plasma concentration of ET-1 in about 300 twins. The results establish and ...
Primitive yeast yields secrets of human cholesterol and drug metabolism
... for clearing half of all known drugs from the body, another involved in making bile and one required for making natural steroid hormones in the adrenal
“Collectively, our experiments suggest that Dap1 acts as a common regulator of cytochrome P450s in mammals,?says Espenshade.
Combined treatment extends life expectancy for lung cancer patients
... that are missed by thermal ablation.
While this study looked only at lung cancer, Dupuy also has pioneered the use of RFA in thyroid, kidney, adrenal
and bone cancer. The combined treatment may have far-reaching effects, Dupuy says.
"You might be able to treat tumors elsewhere in the body with ...
New pathways for autoimmune treatment identified
... gene causes APS1, a disease causing two out of three problems ?an underactive parathyroid, yeast infection of the skin and/or mucous membrane and adrenal
gland insufficiency ?by age 5 and up to 16 autoimmune diseases over a lifetime.
The same mutation causes a defect in i NKT cells, a type of ...
Worm hormone discovery may aid fight against parasitic disease
... by Dr. Mangelsdorf's team are related to how hormone-replacement therapy works in humans. For example, in patients with Addison's disease, the adrenal
glands do not produce enough of the steroids cortisol and aldosterone; in some cases, these glands produce none at all. Replacing the missing ...
Building a better mouse model of lung cancer: FHIT counts
... a condition called Von-Hippel Lindau disease, an inherited disorder characterized by abnormal blood vessel growth in the eyes, brain, spinal cord, adrenal
gland and other parts of the body.
The scientists exposed mice deficient in both genes to a second carcinogen, DMN, which is also found in smoke ...
Disease progression model of pancreatic cancer developed by Penn researchers
... cancer metastases paralleled that seen in the human disease. "In this model, pancreatic cancer metastasizes to the liver, lungs, diaphragm, and adrenal
glands, all the same places that human pancreatic cancer metastasizes," says Tuveson.
The frequency of metastases to these various organ sites was ...