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Navigating in the ocean of molecules

... is available in German . Tracking down new active agents for cancer or malaria treatment could soon ... possible candidates for the development of active agents for use in cancer treatment and malaria. ( ... according to the estimates - are potential active agents. Identifying these islands of biological ...

K-State researchers say after-school programs should promote activity, healthy nutrition

... findings showed that boys were significantly more active than girls during indoor free play and organized ... that overweight students were substantially less active than the students who were not overweight during ... physical activity sessions. Children were more active in free play than when led by adults who were not ...

UCSF researchers identify new drug target for Kaposi's sarcoma

... . Most current antiviral drugs target the active sites of viral proteins, where enzymes and ... drug development in the 1980s, by blocking the active site on the surface of the dimer, but the herpes ... consistently eluded efforts to disrupt it at its active site, the researchers said. The UCSF team set ...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

... focused on advancing new cancer therapeutics active against novel molecular and genetic cancer ... areas to advance the discovery of compounds active against novel molecular and genetic cancer ... novel molecular descriptors that are derived from active compounds within the target family and from the ...

Structural biology scores with protein snapshot

... opening for its substrate diacylglycerol and the active site at the top of the porch. "The active site looks nothing like any other kinase active site it's a unique architecture," Sanders said. ...

Researcher finds Girl Scout meetings provide an opportunity to increase girls' physical activity

... Girls typically are less physically active than boys, but a Kansas State University ... spend some of their leisure time together being active and taking steps together for fun and health," he ... at Girl Scout meetings, as well as new physically active games for the girls. Federal physical activity ...

Protein linked to change in tissue that surround and support breast tumors

... Washington, DC A protein known to be overly active in breast cancer can exist in a form that seems ... in tumor development. "AIB1 and its more active variant potentiate both estrogen and HER2/Neu at ... breast cancer. We knew that AIB1 delta 3 was more active than AIB1 but this study is evidence that we have ...

Brain's problem-solving function at work when we daydream

... study finds that our brains are much more active when we daydream than previously thought. The ... go dormant when we daydream are in fact highly active during these episodes. "Mind wandering is ... "But this study shows our brains are very active when we daydream much ...

Study finds children's activity levels not influenced by more PE time in school

... got little at school made up for it by being more active at home. The scientists, who presented their ... that creating more opportunity for children to be active by providing more playgrounds, sports facilities ... that the opportunities for children to be active have changed over recent years, but we cannot ...

Mosquito parasite may help fight dengue fever

... was clear that the infected mosquitoes were more active than the uninfected insects. Most surprisingly, ... Having found that the insects became more active in response to their bacterial lodgers, Craig ... So why are the infected insects more active than the uninfected insects? McGraw says there ...

IVCC and Syngenta start project for novel insecticidal active ingredient for malaria control

... launched a project to develop a new insecticidal active ingredient for public health applications, as ... to identify lead candidate compounds for a new active ingredient that is effective against adult ... places them in an ideal position to develop new active ingredients for public health applications but ...

When every photon counts

... packed inactive and the less densely packed active regions of DNA differ remarkably from those in ... whereas the less compacted euchromatin with the active DNA regions forms a peripheral shell. This ... is that the central positioning of the active eurochromatin allows more interactions between ...

After a few drinks, older adults more impaired than they think

... GAINESVILLE, Fla. Older, active people who have a drink or two might be more ... levels of alcohol consumption in healthy, active older adults. "You want to know how long does ... might shed more light on alcohol effects in older active adults. ...

Long-sought protein structure may help reveal how 'gene switch' works

... ago to study the structure of CRP in both its active state (with cAMP bound to it) and inactive state ... were able to crystallize the protein in its active ("on") state and examine the structure using a ... step is to crystallize M. tuberculosis CRP in the active state and define its structure," Gallagher says. ...

Snails and humans use same genes to tell right from left

... in the body, that is, molecules that are active on only one side of the body, but nodal is always ... tests showed that nodal and Pitx were active or expressed on the right side of embryos in the ... was sequenced by JGI, suggesting that nodal is active throughout the Lophotrochozoa. "Everybody ...

Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis

... continue his work to develop a test to diagnose active Tuberculosis (TB), the world's second deadliest ... with 1.7 million deaths and 9 million new active cases annually. TB cases are already at epidemic ... most importantly, failure to distinguish between active and latent cases. "We are in the preliminary ...

Brain background to body mass

... of obesity. Five of the genes are known to be active in the brain, suggesting that many genetic ... quo. "Very occasionally, mutations in genes active in the hypothalamus have dramatic consequences ... or most genes associated with increased BMI are active in the brain." Studies in twins suggest that ...

It takes 2 to tango

... side of a synapse was believed to play an active role in this reorganization of the brain, which ... of the points of contact, the spines, plays an active role in the assembly and break-down of new ... unit of a synapse played a considerably more active role in the assembly and disintegration of the ...

Could vitamin D save us from radiation?

... Radiation , Hayes explains that calcitriol, the active form of vitamin D, may protect us from background ... vitamin D, and in particular its biologically active form, could be the key ingredient in radiological ... "It is now becoming recognized that its most active molecular form, 1,25-dihydroxyvitamin D3, may ...

Lung airway cells activate vitamin D and increase immune response

... of Iowa Carver College of Medicine. "The active form of vitamin D is known to affect the ... both in the possible lung-specific production of active vitamin D and in vitamin D-dependent production ... convert the storage form of vitamin D into its active form. "When we put the storage form of vitamin ...

Soil Science Society of America presents awards in Houston

... urban systems, such as golf courses. Ma has been active in the Soil Science Society of America, American ... liaison for Europe of Vadose Zone Journal. He is active in the European Geophysical Union, Soil Science ... for the award must have 25 years or more of active membership in the Society and have ceased ...

Soil Science Society of America presents 2008 fellows

... service. Only .3 percent of the Society's active and emeritus members may be elected Fellow. The ... editor for Vadose Zone Journal, and has been active in the Soil Science Society of America, American ... improved management decisions. He has been active in organizing tri-society meeting symposia, has ...

Indiana University research at American Public Health Association meeting

... Indiana University researchers studied 730 highly active people, ages 20 to 93, to see how their physical ... to establish baseline data, rather than examining active people who could represent model behavior. "The ... as the self-reported diseases demonstrates that active engagement in physical activity improves both ...

Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome

... The genes on the chromosomes can either be active or inactive. If a gene is active on the maternal chromosome, the corresponding gene is usually active also on paternal chromosome. However, in some ...

TB bacterium uses its sugar coat to sweeten its chances of living in lungs

... decades, but an estimated one in 10 will develop active disease characterized by a chronic cough and chest pain. An active infection is treated with a combination of ... and release the bugs into the lungs, leading to active infection. Schlesinger's lab has discovered ...

Entomological Society of America names 2008 award winners

... Colleges in 2007. Baxendale has been an active member of ESA since 1978. Distinguished ... In addition to research, Dr. De Moraes is active in teaching and outreach and is particularly ... Entomology, among other publications. David is active in community activities, serving as a member of ...

Entomological Society of America names new Fellows for 2008

... history of the Lepidoptera. She has been an active researcher, and has authored or co-authored eight ... three winners of ESA's J.H. Comstock Award, eight active university faculty members, and leaders in ... editor for Applied Turfgrass Science , and is active in youth science outreach. He teaches ...

American Chemical Society's Weekly PressPac -- Aug. 27, 2008

... and the use of chemical preservatives. So-called active packaging, which attacks bread mold with ... the researchers say. The scientists prepared active packaging composed of paraffin wax paper with ... #3 FOR IMMEDIATE RELEASE "New Cinnamon-Based active Paper Packaging against Rhizopusstolonifer Food ...

Landmark study opens door to new cancer, aging treatments

... Institute have deciphered the structure of the active region of telomerase, an enzyme that plays a ... is an ideal target for chemotherapy because it is active in almost all human tumors, but inactive in most ... few side effects." The study elucidates the active region of telomerase and provides the first ...

Scientists break record by finding northernmost hydrothermal vent field

... much more common. "We hadn't expected a lot of active venting on ultra-slow spreading ridges," Lilley said. The active chimneys in the new field are mostly black and ... deposit, the vent field must surely have been active for many thousands of years," he said. The ...

Scientists suspect omega-3 fatty acids could slow acute wound healing

... in the blister fluid in people who had taken the active fish oil supplements. The researchers had ... One group took a placebo, and the other took an active supplement containing 1.6 grams of ... group 24 hours after the wounds were created. The active group also had higher levels of IL-6 and TNF-a ...

Weill Cornell science briefs June/July 2008

... available drugs. Gaizo is a reformulation of the active ingredient 5-ASA in currently available drugs. ... the researchers found that 99 percent of the active ingredient in the new pill is released in the ... burden for patients. Because there is more of the active drug per pill, patients can take the drug less ...

Insect warning colors aid cancer and tropical disease drug discovery

... may signal the presence of chemical compounds active against cancer cell lines and tropical parasitic ... to have anti-cancer compounds; those proven to be active against certain disease-carrying parasites; and ... more common on plants that contained compounds active against certain diseases, such as breast cancer ...

UC San Diego researchers identify potential new drug candidates to combat 'bird flu'

... in trouble, because we don't have any anti-virals active against them," said Rommie Amaro, a postdoctoral ... Amaro said, since they bound to both the regular active site and an additional side pocket that opened ... drug through the strategic targeting of multiple active site pockets," said Amaro. Added Cheng, former ...

A molecular switch turns on the flame in 'nature's blowtorch'

... (substrate) can get in and out of the P450 active site, but the oxygen is not "activated," that is, ... from the form in which substrate binds to the active form. After the reaction is finished, the Pdx ... substrate molecule and oxygen move into the active site, the cycle can repeat. The reorientation of ...

Halting methane squanderlust

... with is determining the structure of the active catalyst." That catalyst -- molybdenum oxide ... in the scientific literature about the active phase and reaction mechanism of methane ... Peden, the challenge is to design and produce the active form of the catalyst that could be used for ...

Sugar linkage could lead to better treatment for autoimmune diseases

... (IVIG) has within it a trace amount of a very active material that is effective in relieving the ... disorders. But because of the trace amounts of active material, effective doses of IVIG need to be very ... involved rebuilding the human IVIG into a fully active molecule with a slight modification to a ...

Nitrates in vegetables protect against gastric ulcers

... and subsequent transformation into biologically active nitric oxide in the stomach. The Swedish ... and are then converted into the biologically active substance nitric oxide. This results in our ... and subsequent transformation into biologically active nitric oxide in the stomach. The Swedish ...

Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme

... them in a process known as phosphorylation. The active site where the phosphorylation reaction occurs is ... target for drug development, since blocking the active site would deactivate the enzyme. Unfortunately, the active site of PAK1 shares a molecular architecture ...

Birth of an enzyme

... the 'heart' of the enzymatic machine the active site where the chemical reactions take place. ... occurring in the area surrounding the enzymes active site caused minor structural changes, which in ... increase the speed of substrate release from the active site. 'Reproducing the breathtaking ...
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