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Abnormal in Biological News

Abnormal brain circuits may prevent movement disorder

... uncontrolled movements, particularly twisting and abnormal postures. Studies have shown that muscles ... movements. While their brains show the same abnormal network, only approximately 30% of people who ... explained, "the flow is shut off and the abnormal activity stops." ...

Major breakthrough in early detection and prevention of AMD

... to the eye. Central vision loss occurs when these abnormal blood vessels invade the retina, the ... research team was able to detect these same abnormal blood vessels in the living eyes of mice by ... dots to attach to CCR3 on the surface of the abnormal blood vessels, making them visible with ...

American Chemical Society's Weekly PressPac -- May 13, 2009

... identification and analysis of a group of abnormal proteins in platelets from diabetic donors. The ... of medical conditions. Scientists have known that abnormal platelets in the blood of diabetics may ... platelets from diabetics show almost as many abnormal changes (more than 100) in protein content as ...

Drug prevents seizure progression in model of epilepsy

... Epilepsy is a neurological disorder marked by abnormal electrical activity in the brain that leads to ... spontaneity, leading Barth to believe that the abnormal increased activity of the channels might play a ... believe that targeting the BK channels and the abnormal brain activity that they induce might one day be ...

Small molecules might block mutant protein production in Huntington's disease

... production can stop human cells from making the abnormal molecules that cause Huntington's disease, ... molecules also were effective against the abnormal protein that causes Machado-Joseph disease, a ... are fatal inherited diseases caused by abnormal repeats of a small segment in a person's DNA, or ...

Researchers discover that gene switches on during development of epilepsy

... in calcium channels that help to transmit this abnormal activity throughout the brain." Calcium ... how excitable the cells are, and how easily abnormal activity spreads through the brain. If, as in ... caused brain activity to become increasingly abnormal and epileptic. "Calcium channels underlie ...

Prenatal meth exposure linked to abnormal brain development

... pregnancy has found the drug appears to cause abnormal brain development in children. The research is ... molecules in a child's brain, which can indicate abnormal microscopic brain structures that might reflect abnormal brain development. The scans showed that ...

Simple test helps predict heart attack risk

... considered in the Framingham Risk Score) are abnormal in up to 45 percent of those not considered high ... could be very valuable because the prevalence of abnormal values is high in populations not known to have ... to have at least one of three conditions: an abnormal ABI or elevated plasma fibrinogen or elevated ...

The heart disease mutation carried by 60 million

... "The mutation leads to the formation of an abnormal protein," explained the study leader, Kumarasamy ... Hyderabad, India. "Young people can degrade the abnormal protein and remain healthy, but as they get older ... be developed to enhance the degradation of the abnormal protein and postpone the onset of symptoms. There ...

American Chemical Society's Weekly PressPac -- Jan. 7, 2009

... Researchers in Italy are reporting discovery of abnormal proteins in the saliva of autism patients that ... scientists are searching for biomarkers such as abnormal proteins that appear in the body fluids of ... can work normally. The results suggest that these abnormal proteins might be the clue for anomalies in the ...

In just 5 years, gene discovery to clinical trial of potential treatment

... cell nucleus that were subsequently found to be abnormal in HGPS. Also on the panel will be the ... nucleus. The mutated LMNA gene generates an abnormal Lamin A protein (also called progerin) that ... The end result was the production of an abnormal lamin A protein that is missing a stretch of 50 ...

Syracuse University researchers discover new way to attack some forms of leukemia

... leukemia, a form of cancer that is caused by the abnormal production of white blood cells in the bone ... which may slow or stop the production of the abnormal white blood cells. This drug may help to ... packaged in leukemia cells and help convert the abnormal cells back into normal cells. "Reprogramming ...

Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia

... cross-modal synesthetic experience without abnormal neuronal connections," was conducted by an ... synesthesia (known as synesthetes) experience abnormal interactions between the senses. Digit-color ... to understanding the causes of synesthesia and abnormal cross-brain interactions." ...

'Addicted' cells provide early cancer diagnosis

... or for silence. It is well known that the abnormal behaviour of cancer cells is partly due to ... switch off genes that would otherwise cause abnormal cells to destroy themselves. Scientists at ... of tumours by causing the 'addiction' of cells to abnormal gene expression. Some of these changes seem ...

Autism Speaks collaborates on grant with the Allen Institute for Brain Science and autism expert

... growth during the first two years of life. The abnormal overgrowth is especially pronounced in brain ... emotional and language communication. "Such abnormal early brain overgrowth very likely triggers ... specific brain cells and genes involved in the abnormal growth, it will be possible to see more clearly ...

Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice

... treated and prevented the diseases by inhibiting abnormal blood vessel growth and by stabilizing blood vessels to prevent leakage. abnormal blood vessel growth and leakage are two primary ... of new signaling pathways that prevent abnormal vessel growth and leakage in the eye represents a ...

USC researchers explore genetic causes for male infertility

... that a broad epigenetic defect is associated with abnormal semen development, says Rebecca Sokol, M.D., MPH, ... that sperm DNA from men with low sperm counts or abnormal sperm had high levels of methylation, which is ... of epigenetic programming can result in abnormal gene activity or function, even if there is no ...

New treatment for age-related macular degeneration within sight

... to mice significantly reduced or eliminated abnormal blood vessel growth within the eye, which is ... In the mice lacking endostatin, the number of abnormal blood vessels that cause AMD were reduced to ... with normal levels of endostatin, the number of abnormal blood vessels were practically undetectable. ...

JCI table of contents: Aug. 16, 2007

... OPHTHALMOLOGY: Eyeing up a role for S1P2R in abnormal blood vessel formation Many millions of ... vision loss as a result of the formation of an abnormal network of blood vessels in the eye. This abnormal blood vessel network forms in response to damage ...

La Jolla Institute discovers novel tumor suppressor

... STAT5 goes into a state of constant activation, causing the development of abnormal myeloid cells," said Dr. Kawakami. The abnormal cells, which are essentially tumor cells, become overactive and produce ...

UC San Diego engineer provides insights to decades-old DNA squabble

... example, he said, lots of diseases including cancer are directly linked to abnormal regulation of chromatin. The structure of chromatin has been a subject ... into biology," he added. "When we talk about cancer and its link to abnormal gene regulation, we have to ask the question why are these genes ...

New test can detect both genetic and chromosomal abnormalities in embryos

... cystic fibrosis, but that it was also capable of detecting aneuploidy (an abnormal number of any of the 23 pairs of chromosome) at the same time. This is the ... "The range of applications is broad and includes single gene defects, abnormal chromosome number, structural chromosome abnormalities and HLA [human ...

The battle for CRTC2: How obesity increases the risk for diabetes

... glucose levels. We asked whether chronic ER stress in obesity leads to abnormal activation of the fasting switch that normally controls glucose production ... have a stronger tendency to become diabetic. When ER stress signaling is abnormal glucose output is actually increased." "It is possible that mutations ...

Preclinical work shows how one gene causes severe mental retardation

... to learn if this experience-dependent reorganization of the cortex was abnormal in animals that were missing the gene," said Michael Ehlers, M.D., Ph.D., ... are important for language, cognition and emotion, all of which are quite abnormal in Angelman syndrome patients." The authors found that brains cells in ...

Scaling the wall of deafness

... know where the process starts to break down. For some reason, there is an abnormal development or wearing down of specialized sensory cells, called hair ... Avraham. The work in fish suggests that microRNA mutations may also cause abnormal development of the inner ear in embryos and deafness in newborns. ...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

... the normal gene has a sequence of between six and 34 CAG repeats, the abnormal gene contains many more. In fact, any stretch of DNA containing more than ... repeats, the earlier the disease strikes and the greater its ferocity. The abnormal Huntingtin protein causes movement disorders, cognitive failure, and ...

NIH funds research center for women's reproductive health at Einstein

... endometriosis, and endometrial cancer." Endometriosis, the abnormal growth of endometrial tissue outside the uterus, is one of the most common ... in the U.S. were diagnosed with endometrial cancer, another disease of abnormal cell growth in the endometrium, and 7,470 died of the disease, according ...

Cellular discovery may lead to targeted treatment for rare form of anemia

... to a ribosomal protein defect that the UC team hypothesizes leads to abnormal activation of p53, causing premature death of red blood cells. P53 is a ... life. "By understanding the chain of biological events leading to this abnormal cell death and targeting the specific molecular checkpoint that controls ...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

... in a Drosophila (fruit fly) model of the disease, showing low and abnormal cardiolipin concentration, abnormal mitochondria, and poor motor function. In this new study researchers ...

Scientists identify cell changes leading to impaired 'artificial kidney' function

... fluid from PD patients, and identified molecular signals that cause abnormal changes in the peritoneum. They also found that pharmacologically disrupting these signals causes these abnormal cells to revert back to their original state, as they normally existed in ...

Researchers identify Achilles heel of common childhood tumor

... cells that lined the affected blood vessels were all derived from the same abnormal cell. Like other tumors, hemangiomas are caused by the abnormal proliferation of tissue. Since no other type of cell within the tissue ...

Risks and benefits of antipsychotics in children and adolescents

... in the short-term and longer-term treatment groups, respectively. abnormal involuntary movements The incidence of extrapyramidal symptoms (EPS), ... activities. In a cross-sectional study by our group, the presence of abnormal involuntary movements was compared in 60 children and adolescents who had ...

Research expedition on corals and global warming: Aug. 17-26 in Puerto Rico

... in order to pinpoint those offspring whose parents can tolerate abnormal water conditions. Once Baums identifies these individuals, she will ... their genomes for variants of genes that are responsible for resistance to abnormal water temperatures. With this knowledge, she then can develop genetic ...

Pre-cancerous condition linked to chronic acid reflux faces several hurdles

... is not a routine procedure. The biological basis of Barrett's is an abnormal change, or dysplasia, in the oesophagus. Normally, the oesophagus is lined ... columnar cells. This process of normal cells morphing into abnormal cells is common to several types of cancer, not just oesophageal cancer. ...

Treatment corrects severe insulin imbalance in animal studies

... of HI, in which mutations prevent those channels from forming. When the abnormal beta cells are confined to a discrete portion of the pancreas, as occurs ... lesions and performing the curative surgery on newborns. However, when abnormal cells are distributed throughout the pancreas in so-called diffuse HI, ...

Gaining ground on sickle cell disease

... cell disease, a single genetic mutation results in the production of an abnormal type of hemoglobin, the main component of red blood cells. The abnormal hemoglobin molecules tend to form long chains, causing red blood cells to ...

IVF does not increase risk of developmental disorders in children

... that singleton children born after IVF were not at increased risk for abnormal general movements. This suggests that they are not at increased risk of ... neurological condition in early infancy," said Dr. Middelburg. "Mildly abnormal general movements occurred more frequently in the children born to ...

NCI grant launches clinical trials for colon cancer screening

... by a primary care physician during an annual exam. Only patients with abnormal results would go on to have the more invasive and expensive colonoscopy. ... light scattering effects and is minimally invasive. The method can detect abnormal changes in cells lining the colon long before those changes can be seen ...

Certain anticancer agents could be harmful to patients with heart disease

... scientists noted the spiky, hedgehog-like appearance of fly embryos with abnormal hedgehog genes. Every organism in the animal kingdom has hedgehog genes, ... who might be treated with hedgehog antagonists." Studies suggest that abnormal activation of the hedgehog pathway is implicated in many different types ...

Drug reverses mental retardation caused by genetic disorder

... even in the adult brain." "These findings challenge the theory that abnormal brain development is to blame for mental impairment in tuberous ... traced the source of the learning problems to biochemical changes sparking abnormal function of the hippocampus, a brain structure that plays a key role in ...
Other Contents
(Date:7/25/2014)... A study published online in the International Journal ... approach to preventing cervical cancer based on findings showing ... removal of a discrete population of cells in the ... that looked at squamocolumnar junction cells, or SCJ cells. ... been implicated as the origins of cervical cancer. A ...
(Date:7/25/2014)... factor characterized by the existence of numerous isoforms ... to the protein deeply different characteristics. NRG1 plays ... during development and the different phases occurring after ... regrowth, remyelination and target reinnervation, Researchers at the ... soluble NRG1 upregulation observed in Schwann cells immediately ...
(Date:7/25/2014)... of a molecular testing panel developed at UPMC ... initial surgery for patients with thyroid nodules and ... Cancer Institute (UPCI), partner with UPMC CancerCenter., The ... and other diagnostic testing agencies, improved the chances ... 30 percent, according to the study published this ...
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