Abnormal brain circuits may prevent movement disorder
... uncontrolled movements, particularly twisting and abnormal
postures. Studies have shown that muscles ... movements.
While their brains show the same abnormal
network, only approximately 30% of people who ... explained, "the flow is shut off and the abnormal
Major breakthrough in early detection and prevention of AMD
... to the eye. Central vision loss occurs when these abnormal
blood vessels invade the retina, the ... research team was able to detect these same abnormal
blood vessels in the living eyes of mice by ... dots to attach to CCR3 on the surface of the abnormal
blood vessels, making them visible with ...
American Chemical Society's Weekly PressPac -- May 13, 2009
... identification and analysis of a group of abnormal
proteins in platelets from diabetic donors. The ... of medical conditions. Scientists have known that abnormal
platelets in the blood of diabetics may ... platelets from diabetics show almost as many abnormal
changes (more than 100) in protein content as ...
Drug prevents seizure progression in model of epilepsy
Epilepsy is a neurological disorder marked by abnormal
electrical activity in the brain that leads to ... spontaneity, leading Barth to believe that the abnormal
increased activity of the channels might play a ... believe that targeting the BK channels and the abnormal
brain activity that they induce might one day be ...
Small molecules might block mutant protein production in Huntington's disease
... production can stop human cells from making the abnormal
molecules that cause Huntington's disease, ... molecules also were effective against the abnormal
protein that causes Machado-Joseph disease, a ... are fatal inherited diseases caused by abnormal
repeats of a small segment in a person's DNA, or ...
Researchers discover that gene switches on during development of epilepsy
... in calcium channels that help to transmit this abnormal
activity throughout the brain."
Calcium ... how excitable the cells are, and how easily abnormal
activity spreads through the brain.
If, as in ... caused brain activity to become increasingly abnormal
"Calcium channels underlie ...
Prenatal meth exposure linked to abnormal brain development
... pregnancy has found the drug appears to cause abnormal
brain development in children. The research is ... molecules in a child's brain, which can indicate abnormal
microscopic brain structures that might reflect abnormal
The scans showed that ...
Simple test helps predict heart attack risk
... considered in the Framingham Risk Score) are abnormal
in up to 45 percent of those not considered high ... could be very valuable because the prevalence of abnormal
values is high in populations not known to have ... to have at least one of three conditions: an abnormal
ABI or elevated plasma fibrinogen or elevated ...
The heart disease mutation carried by 60 million
"The mutation leads to the formation of an abnormal
protein," explained the study leader, Kumarasamy ... Hyderabad, India. "Young people can degrade the abnormal
protein and remain healthy, but as they get older ... be developed to enhance the degradation of the abnormal
protein and postpone the onset of symptoms. There ...
American Chemical Society's Weekly PressPac -- Jan. 7, 2009
... Researchers in Italy are reporting discovery of abnormal
proteins in the saliva of autism patients that ... scientists are searching for biomarkers such as abnormal
proteins that appear in the body fluids of ... can work normally. The results suggest that these abnormal
proteins might be the clue for anomalies in the ...
In just 5 years, gene discovery to clinical trial of potential treatment
... cell nucleus that were subsequently found to be abnormal
Also on the panel will be the ... nucleus. The mutated LMNA gene generates an abnormal
Lamin A protein (also called progerin) that ... The end result was the production of an abnormal
lamin A protein that is missing a stretch of 50 ...
Syracuse University researchers discover new way to attack some forms of leukemia
... leukemia, a form of cancer that is caused by the abnormal
production of white blood cells in the bone ... which may slow or stop the production of the abnormal
white blood cells. This drug may help to ... packaged in leukemia cells and help convert the abnormal
cells back into normal cells.
Ben-Gurion University of the Negev researchers help find that hypnosis can induce synesthesia
... cross-modal synesthetic experience without abnormal
neuronal connections," was conducted by an ... synesthesia (known as synesthetes) experience abnormal
interactions between the senses. Digit-color ... to understanding the causes of synesthesia and abnormal
'Addicted' cells provide early cancer diagnosis
... or for silence. It is well known that the abnormal
behaviour of cancer cells is partly due to ... switch off genes that would otherwise cause abnormal
cells to destroy themselves.
Scientists at ... of tumours by causing the 'addiction' of cells to abnormal
Some of these changes seem ...
Autism Speaks collaborates on grant with the Allen Institute for Brain Science and autism expert
... growth during the first two years of life. The abnormal
overgrowth is especially pronounced in brain ... emotional and language communication.
early brain overgrowth very likely triggers ... specific brain cells and genes involved in the abnormal
growth, it will be possible to see more clearly ...
Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice
... treated and prevented the diseases by inhibiting abnormal
blood vessel growth and by stabilizing blood vessels to prevent leakage. abnormal
blood vessel growth and leakage are two primary ... of new signaling pathways that prevent abnormal
vessel growth and leakage in the eye represents a ...
USC researchers explore genetic causes for male infertility
... that a broad epigenetic defect is associated with abnormal
semen development, says Rebecca Sokol, M.D., MPH, ... that sperm DNA from men with low sperm counts or abnormal
sperm had high levels of methylation, which is ... of epigenetic programming can result in abnormal
gene activity or function, even if there is no ...
New treatment for age-related macular degeneration within sight
... to mice significantly reduced or eliminated abnormal
blood vessel growth within the eye, which is ... In the mice lacking endostatin, the number of abnormal
blood vessels that cause AMD were reduced to ... with normal levels of endostatin, the number of abnormal
blood vessels were practically undetectable.
JCI table of contents: Aug. 16, 2007
OPHTHALMOLOGY: Eyeing up a role for S1P2R in abnormal
blood vessel formation
Many millions of ... vision loss as a result of the formation of an abnormal
network of blood vessels in the eye. This abnormal
blood vessel network forms in response to damage ...
La Jolla Institute discovers novel tumor suppressor
... STAT5 goes into a state of constant activation, causing the development of abnormal
myeloid cells," said Dr. Kawakami. The abnormal
cells, which are essentially tumor cells, become overactive and produce ...
UC San Diego engineer provides insights to decades-old DNA squabble
... example, he said, lots of diseases including cancer are directly linked to abnormal
regulation of chromatin.
The structure of chromatin has been a subject ... into biology," he added.
"When we talk about cancer and its link to abnormal
gene regulation, we have to ask the question why are these genes ...
New test can detect both genetic and chromosomal abnormalities in embryos
... cystic fibrosis, but that it was also capable of detecting aneuploidy (an abnormal
number of any of the 23 pairs of chromosome) at the same time. This is the ...
"The range of applications is broad and includes single gene defects, abnormal
chromosome number, structural chromosome abnormalities and HLA [human ...
The battle for CRTC2: How obesity increases the risk for diabetes
... glucose levels. We asked whether chronic ER stress in obesity leads to abnormal
activation of the fasting switch that normally controls glucose production ... have a stronger tendency to become diabetic. When ER stress signaling is abnormal
glucose output is actually increased."
"It is possible that mutations ...
Preclinical work shows how one gene causes severe mental retardation
... to learn if this experience-dependent reorganization of the cortex was abnormal
in animals that were missing the gene," said Michael Ehlers, M.D., Ph.D., ... are important for language, cognition and emotion, all of which are quite abnormal
in Angelman syndrome patients."
The authors found that brains cells in ...
Scaling the wall of deafness
... know where the process starts to break down. For some reason, there is an abnormal
development or wearing down of specialized sensory cells, called hair ... Avraham. The work in fish suggests that microRNA mutations may also cause abnormal
development of the inner ear in embryos and deafness in newborns.
New therapeutic strategy could target toxic protein in most patients with Huntington's disease
... the normal gene has a sequence of between six and 34 CAG repeats, the abnormal
gene contains many more. In fact, any stretch of DNA containing more than ... repeats, the earlier the disease strikes and the greater its ferocity. The abnormal
Huntingtin protein causes movement disorders, cognitive failure, and ...
NIH funds research center for women's reproductive health at Einstein
... endometriosis, and endometrial cancer."
Endometriosis, the abnormal
growth of endometrial tissue outside the uterus, is one of the most common ... in the U.S. were diagnosed with endometrial cancer, another disease of abnormal
cell growth in the endometrium, and 7,470 died of the disease, according ...
Cellular discovery may lead to targeted treatment for rare form of anemia
... to a ribosomal protein defect that the UC team hypothesizes leads to abnormal
activation of p53, causing premature death of red blood cells. P53 is a ... life.
"By understanding the chain of biological events leading to this abnormal
cell death and targeting the specific molecular checkpoint that controls ...
New potential therapeutic target discovered for genetic disorder -- Barth syndrome
... in a Drosophila (fruit fly) model of the disease, showing low and abnormal
cardiolipin concentration, abnormal
mitochondria, and poor motor function. In this new study researchers ...
Scientists identify cell changes leading to impaired 'artificial kidney' function
... fluid from PD patients, and identified molecular signals that cause abnormal
changes in the peritoneum. They also found that pharmacologically disrupting these signals causes these abnormal
cells to revert back to their original state, as they normally existed in ...
Researchers identify Achilles heel of common childhood tumor
... cells that lined the affected blood vessels were all derived from the same abnormal
cell. Like other tumors, hemangiomas are caused by the abnormal
proliferation of tissue. Since no other type of cell within the tissue ...
Risks and benefits of antipsychotics in children and adolescents
... in the short-term and longer-term treatment groups, respectively.
The incidence of extrapyramidal symptoms (EPS), ... activities.
In a cross-sectional study by our group, the presence of abnormal
involuntary movements was compared in 60 children and adolescents who had ...
Research expedition on corals and global warming: Aug. 17-26 in Puerto Rico
... in order to pinpoint those offspring whose parents can tolerate abnormal
water conditions. Once Baums identifies these individuals, she will ... their genomes for variants of genes that are responsible for resistance to abnormal
water temperatures. With this knowledge, she then can develop genetic ...
Pre-cancerous condition linked to chronic acid reflux faces several hurdles
... is not a routine procedure.
The biological basis of Barrett's is an abnormal
change, or dysplasia, in the oesophagus. Normally, the oesophagus is lined ... columnar cells. This process of normal cells morphing into abnormal
cells is common to several types of cancer, not just oesophageal cancer. ...
Treatment corrects severe insulin imbalance in animal studies
... of HI, in which mutations prevent those channels from forming.
When the abnormal
beta cells are confined to a discrete portion of the pancreas, as occurs ... lesions and performing the curative surgery on newborns.
However, when abnormal
cells are distributed throughout the pancreas in so-called diffuse HI, ...
Gaining ground on sickle cell disease
... cell disease, a single genetic mutation results in the production of an abnormal
type of hemoglobin, the main component of red blood cells. The abnormal
hemoglobin molecules tend to form long chains, causing red blood cells to ...
IVF does not increase risk of developmental disorders in children
... that singleton children born after IVF were not at increased risk for abnormal
general movements. This suggests that they are not at increased risk of ... neurological condition in early infancy," said Dr. Middelburg. "Mildly abnormal
general movements occurred more frequently in the children born to ...
NCI grant launches clinical trials for colon cancer screening
... by a primary care physician during an annual exam. Only patients with abnormal
results would go on to have the more invasive and expensive colonoscopy. ... light scattering effects and is minimally invasive. The method can detect abnormal
changes in cells lining the colon long before those changes can be seen ...
Certain anticancer agents could be harmful to patients with heart disease
... scientists noted the spiky, hedgehog-like appearance of fly embryos with abnormal
hedgehog genes. Every organism in the animal kingdom has hedgehog genes, ... who might be treated with hedgehog antagonists."
Studies suggest that abnormal
activation of the hedgehog pathway is implicated in many different types ...
Drug reverses mental retardation caused by genetic disorder
... even in the adult brain."
"These findings challenge the theory that abnormal
brain development is to blame for mental impairment in tuberous ... traced the source of the learning problems to biochemical changes sparking abnormal
function of the hippocampus, a brain structure that plays a key role in ...