New evidence explains poor infant immune response to certain vaccines, says MU researcher
... reacted when they were repeatedly exposed to an antigen
that simulates a virus.
Zaghouani found that while the antigen
would prompt a response of the immune system, it ... to help destroy the foreign microbes. When an antigen
from a vaccine enters a body with a mature immune ...
From foe to friend: Researchers use salmonella as a way to administer vaccines in the body
... organism that can effectively deliver an antigen
in the body. The researchers report that they ... and effective means of biological containment for antigen
delivery. The method not only effectively delivers the antigen
in the body, but does so in a way that does not ...
A protein sequence associated with Huntingtons disease may become life-saving vaccine component
The major component of every vaccine is an antigen
that elicits specific immunity to a particular ... test if attachment of a long polyQ "tail" to an antigen
can enhance immune response to vaccination". First, he noticed that small aggregates formed by an antigen
fused to a polyQ tail resembled the droplets that ...
New technology for boosting vaccine efficiency
... of two major elements. First, each vaccine antigen
should be made in two forms. One is easily ... to the chopping. Thus both these forms of an antigen
would be used in combination to elicit a much ... presented by the cell to our immune system. This antigen
presentation process is very complex and remains ...
Arbor Vita rapid H5N1 flu diagnostic presented at ICEID meeting
... Research Center (NHRC) suggests that a rapid antigen
assay test developed by Arbor Vita Corporation ... protein, as opposed to the nucleoprotein (NP). antigen
capture is mediated through a PDZ protein, which ... assay is the familiar lateral-flow rapid antigen
assay. However, the role of the capture antibody ...
Gene therapy protocol at UCSD activates immune system in patients with leukemia
... antibodies reactive with a leukemia-associated antigen
a protein made by leukemia cells that can ... system to produce antibodies called ROR1. This antigen
appears to be found only on the cell surface of ... said.
He also noted that because the ROR1 antigen
is found only on leukemia cells, it could be ...
New medications show promise in treating drug-resistant prostate cancer
... safety, 22 showed a sustained decline in the level of prostate specific antigen
(PSA) in their blood. Phase III clinical trials are planned to evaluate ... men showed a sustained decline in their blood levels of prostate specific antigen
(PSA), an indication that their cancer was responding favorably to the ...
Researchers identify potential new weapon in battle against HIV infection
... (≈ 1 in a million) who produce excess of this blood group antigen
have dramatically reduced sensitivity to HIV infection. Conversely, ... blood status in fighting the infection."
Increasing the level of the Pk antigen
in cells in the laboratory also resulted in heightened resistance to HIV, ...
Nano vaccine for hepatitis B shows promise for third world
... PLoS ONE .
The nanoemulsion represents a new delivery method for an antigen
already used in existing hepatitis B vaccines to activate the body's ... Research details:
The research team determined effective doses of the antigen
and nanoemulsion. In results obtained in mice, rats and guinea pigs, the ...
Prostate cancer vaccines more effective with hormone therapy
... randomly assigned to receive either a poxvirus-based prostate-specific antigen
vaccine or hormone therapy with nilutamide. At progression, patients ... to vaccine plus hormone, due to rising levels of prostate-specific antigen
with no evidence of metastasis. For patients who received vaccine and then ...
Nucleonics initiates hepatitis B clinical trial with expressed interfering RNA therapeutic
... HBV therapeutics, NUCB1000 is designed to specifically reduce viral antigen
load in addition to viral titer, thereby reducing the destructive effects ... including HBV viral levels in the blood and circulating HBV surface antigen
(HBsAg) levels. An independent safety monitor as well as a data safety ...
New field-deployable biosensor detects avian influenza virus in minutes instead of days
... real-time reverse transcriptase polymerase chain reaction (RRT-PCR) and antigen
capture immunoassays. Virus isolation is a sensitive technique, but ... but routine surveillance samples are more often processed in 24 hours. The antigen
capture immunoassays can provide rapid test results, but suffer from low ...
Clearance of hepatitis C viral infection after liver transplantation
... modified polypeptide medicine. Five weeks after the PEG-IFN treatment, HCV antigen
was no longer detectable from the patient serum, but HCV-RNA persisted. ... a patient who was diagnosed positive in HCV-RNA and negative in HCV core antigen
before LT. Dr. Ichikawa suggested that the long acting of PEG-IFN might ...
LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia
... antibodies are part of the natural response repertoire to the Pneumocystis fungus, but also that when combined with a potent protein antigen
called Kex1, these antibodies can regulate direct killing of the fungus and confer immunity.
"Understanding these antibody responses will improve ...
Green tea may affect prostate cancer progression
... patients with prostate cancer. The biomarkers include hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen
(PSA). HGF and VEGF are good prognostic indicators of metastatic disease.
The study included 26 men, aged 41 to 72 years, diagnosed with prostate ...
Partnership to accelerate Trudeau Institute discoveries to patient care
... hundreds of patents and technology licenses that have resulted in the commercialization of medical advancements, such as the Prostate Specific antigen
test ("PSA test"), HIV-1 co-receptor usage test, photodynamic cancer therapy, assistive communication devices for persons with spinal cord injuries, ...
Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
... PGN632 also induced an increase in the expression of cell-surface molecules that are indicative of mature dendritic cells and that assist in antigen
presentation functions, as well as in stimulating T-cell proliferation.
Dr. Xianming Huang, assistant professor of pharmacology at UT Southwestern ...
Newly discovered epidermal growth factor receptor active in human pancreatic cancers
... cancers and a potential blood or urine screening tool that might eventually do for pancreatic cancer detection what biomarkers like prostate-specific antigen
levels have done for prostate cancer. His presentation was part of the scientific program of the American Society for Investigative Pathology.
Burnham researchers present at 100th AACR Meeting
... Receptor-Mediated Apoptosis and Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NFκB Activation Induced by Protein Kinase C and antigen
Changming Fang, Ph.D., who will also present two papers: Ileal Bile Acid Binding Protein Mediates the Chemopreventative Effect of ...
New drug shows promise in treating drug-resistant prostate cancer
... which block the androgen receptor (AR) in CRPC cells, and report results from clinical trials in which MDV3100 was found to lower prostate-specific antigen
(PSA) levels a marker for tumor growth in men with CRPC.
The new, small organic molecule MDV3100 was "designed as a very strong antagonist of ...
Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
... cell-related signaling is the dominant mechanism of anticancer activity, but we have also known that the normal job of an antibody is to deliver an antigen
to the body's immune system which then destroys the target," Weiner says.
Recent research by Weiner and others, however, now shows that ...
Twin nanoparticle shown effective at targeting, killing breast cancer cells
... a protein located on the surface on the malignant cell. Put another way, the nanoparticle vehicle "docks" on the tumor cell when the antibody and the antigen
become connected. Once docked, the vehicle unloads its "passenger," the cisplatin, into the malignant cell.
"It's like a magic bullet," said ...
Freezing prostate cancer does a man's body good
... the disease," said Onik. He studied 120 men who had focal cryoablation over the past 12 years, including testing the levels of prostate-specific antigen
(PSA) in the blood. Of those patients, 112 (93 percent) had no evidence of cancerin spite of 72 being labeled medium to high risk for cancer ...
HIV adapts to 'escape' immune response
... design is formidable," he said.
The researchers looked at different DNA variations of HIV in conjunction with different forms of human leukocyte antigen
(HLA), a group of molecules that orchestrate immune response. Normally HLA molecules present fragments of HIV proteins on the surface of infected ...
New lab evidence suggests preventive effect of herbal supplement in prostate cancer
... said Arnold.
Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells and prostate specific antigen
protein secretion two to four-fold and gene expression up to 50-fold in the cancer cells. When these cell cultures were treated with red clover ...
Molecule that suppresses immune response under study in type 1 diabetes
... inflammation, which causes dendritic cells to express IDO, at the same time they give antigens to the insulin-producing cells. "The presence of the antigen
excites the T cells if you will, but the presence of IDO tells it to stop getting excited," said Dr. Mellor. The approach has its risks. "The ...
'Femtomolar optical tweezers' may enable sensitive blood tests
... to the sphere. This in turn can detect and count biological antigens at extraordinarily low "femtomolar" concentrationsroughly equivalent to one antigen
particle per quadrillion (1,000,000,000,000,000) water molecules.
A double-barreled immune cell approach for neuroblastoma
... and onto the tumor."
Thus these cytotoxic T-lymphocytes remain in the body because they are constantly stimulated by the virus. Their artificial antigen
receptor enables them to latch onto and kill the cancer cells.
When the researchers put the artificial receptor into both ordinary T-lymphocytes ...
Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration
... fasting C-peptide level, C-peptide increase during screening mixed meal tolerance test, and presence of antibodies to at least one beta cell antigen
(insulin, GAD-65, or IA-2). ClinicalTrials.gov Identifier: NCT00453375.
A card-swipe for medical tests
... The Utah scientists cite examples of how a GMR card reader might be used medically for humans and animals:
Current tests for prostate specific antigen
(PSA) an indicator for possible prostate cancer only look for "free" PSA but not for other forms. A card-like sample stick with multiple ...
Research identifies type of vaccine that holds promise in protecting against TB
... TB germ from one of the strains of the current tuberculosis vaccine, which was created more than 75 years ago. The new "recombinant" vaccine uses an antigen
a secreted protein from a virulent strain of tuberculosis to help focus the immune system on blocking aggressive and deadly TB organisms.
Sensitive nanowire disease detectors made by Yale scientists
... activation of this small number of T cells. The new report expands that work and shows the nanowires can identify activation from a single specific antigen
even when there is substantial background "noise" from a general immune stimulation of other cells.
Describing the sensitivity of the system, ...
Children's National researchers develop novel anti-tumor vaccine
... National Chief of General and Thoracic Surgery Anthony Sandler, MD , involves the creation of synthetic microparticles known as "immune stimulatory antigen
loaded particles" (ISAPs), that consist of tumor antigens (proteins) from the specific tumor to be targeted, as well as immune stimulatory agents. ...
Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
... the herbicide with this form of cancer. The research is also the first to utilize a large population of men in their 60s and the prostate-specific antigen
(PSA) test to screen for the disease.
"While others have linked Agent Orange to cancers such as soft-tissue sarcomas, Hodgkin's disease and ...
Immunotherapy in high-risk pediatric sarcomas shows promising response
... aphaeresis to harvest blood lymphocytes that were then frozen. From this, dendritic cells were later extracted. These are cells that present an antigen
to T cells and other immune system fighters in order to elicit a response.
All patients then had chemotherapy, radiation or surgery, as ...
Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds
... of patients for adjuvant therapy, prediction of response to therapy and early intervention when the disease does recur. Although carcinoembryonic antigen
(CEA) and plasma DNA are known to be elevated in patients with esophageal cancer and are higher in patients with metastatic disease, the sensitivity ...
Human embryonic stem cells developed from 4-cell embryo; world first may lessen ethical concerns
... stage turns out to be more efficient then at the 8-cell stage, we might consider to change our PGD policy in cases where we perform human leukocyte antigen
(HLA) typing," said Dr. Van de Velde.
HLA molecules play an important role in the immune system by ensuring that our bodies recognise their own ...
Counting tumor cells in blood predicts treatment benefit in prostate cancer
... tumor cell counts could provide information about how patients are responding to therapy earlier than other markers such as prostate-specific antigen
(PSA) or time-to-disease progression," he said. "We have observed that patients with declining numbers of circulating tumor cells can see a change in ...
Genes may play role in risk assessment for prostate cancer among Hispanics and caucasians
... of the American Association for Cancer Research.
Currently, the most common method for assessing risk for prostate cancer is the prostate specific antigen
test, but this method can identify tumors that may not be a threat to the health of a man and misses other tumors.
Men typically have this test ...
Cancer immunotherapy shows long-term promise in lung cancer
... expressed in 35-50% of non-small-cell lung cancer, but not on normal cells.
"The aim is to help the body immune system to recognize the MAGE-A3 antigen
and therefore eliminate the cancer cells that express MAGE-A3," explains Prof. Vansteenkiste. "In other words, it is a kind of treatment method that ...