map

Y chromosome

...sents a number of unique problems to both genetic map ping and gene identification. Full article >>> Y chromosome YeastA unicellular fungus . One species , the budding yeast Saccharomyces cerevisiae , is used in brewing and baking because of the ease with which it ferments car...

X chromosome

...permitted a refined comparison between a physical map and a genetic map , which is constructed by studying the passage of trait s from one generation to another. Full art...

Variation

... sequence s can be used as marker s on physical map s and linkage map s. RFLP is also pronounced "rif" lip. Full article >>> Without variation (which a...

Transposable element

Transposable element s are used to map genes. Facts A segment of a bacteria l genome , as a cosmid clone , has been identified by complementation as containing a functional gene . The precise location of the gene on the cosmid is not known. Full article >>> T...

Transduction

...tic marker s in bacteria can be used in genetic map making. Facts ... Full article >>> The movement of genes from a bacteria l donor to a bacteria l recipient using a phage as the vector . A process whereby a cell can gain access to and incorporate foreign DNA brought in by a...

Tandem repeat sequence

...on a chromosome ; used as a marker in physical map ping, when the number of repeats varies in the ... on a chromosome ; used as marker s in physical map ping. See also: physical map ... Full article >>> Tandem repeat sequence s : Mul...

Tandem repeat sequences

... on a chromosome ; used as marker s in physical map ping. See also: physical map ... Full article >>> Tandem repeat sequences : Multiple copies of the same base se...

Species

... Full article >>> Genetic linkage map -- a chromosome map showing the relative positions of the known genes on the chromosomes of a given species . Geneti...

Sequencing

...ome , Human Genome Project , mapping , physical map , polymerase chain re action ( PCR ) [ Send this term to a friend ] [ Suggest a term for the glossary ] See Also: ... Full article >>> When a sequencing re action is performed using such DNA , a protected area representing the f...

Sequence Polymorphism

...hism which results in changes in the restriction map . Other Resources PubMed Google ... Full article >>> Sequence Polymorphism : See Polymorphism . Sequence similarity : Similarity in nucleic acid or polypeptide sequence s, particularly in shorter segment s, that may not be s...

Sequence

...DNA sequence . STSs can be used to form genetic map s by standard mapping procedures. A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ... Full article >>> Simple Sequence Repeat (SSR) Short, tandem repeats that are useful as genetic marker s See also PCR Glossary. Other R...

Selection

...icial selection . Genetic linkage map. A linear map of the relative positions of genes along a chromosome . Full article >>> Hardy-Weinberg Law -- the concept that both gene frequencies and genotype frequencies will remain constant from generation to generation in an infinitely lar...

Segment

...of an unknown gene on a chromosome or linkage map . Full article >>> palindrome A se...>>> A ‘ contig ' may refer to a map showing placement of a set of clones that completely, contig uously cover some segment of DNA ...

Screening

...enomic region of interest as well as for physical map ping. Full article >>> The AFLP procedure typically detects more polymorphisms per re action than RFLP or RAPD ana lysis . AFLP ana lysis is especially useful in screening backcross individuals. Protocols for AFLP a...

Scale

... spiny leaves. Full article >>> The map usually indicates the approximate length of the entire piece ( scale on the bottom), as well as the position within the piece at which designated enzymes will cut. Full article >>> crawler. The active first instar of a scale insec...

RT-PCR

...hism ( RFLP ) Restriction enzyme Restriction map ... Full article >>> New Gene - Expression Data and Query Form: Data set of RT-PCR assays produced by Tom Freeman's laboratory represents analyses of 517 genes in 46 mouse tissue s from animals 6 to 8 weeks old and studies of...

RFLP

...hism which results in changes in the restriction map . Other Resources ... Full article >>>...gths detected by Southern ana lysis . Restriction map . See Mapping . Retrovirus . Full article >>> Gusella and his research team, who us...

Restriction map

Restriction map A brief sketch of the positions of some restrict...s ... Full article >>> Restriction map ping is the process of determining the restriction site s on a target DNA molecule associated w...

Restriction fragment

...hism which results in changes in the restriction map . Other Resources ... Full article >>>...in RFLP s are used as marker s on both physical map s and genetic linkage maps. Full article >>> Restriction Fragment Length Polymor...

Restriction enzymes

...); useful as genetic marker s for making linkage map s. Full article >>> restriction map - diagrammatic representation of a DNA molecule indicating the sites of cleavage by various ...

Restriction enzyme

...ase . Full article >>> restriction map - diagrammatic representation of a DNA molecule indicating the sites of cleavage by various restriction enzyme s ... Full article >>> Usually generated by the action of restriction enzyme s . cointegrate An intermediate i...

Restriction site

... transcriptase . Full article >>> A map showing physical locations on a DNA molecule , such as restriction site s, and sequence -tagged sites. (See Mapping .) Plant Pest Act (PPA). See U.S. Department of Agri culture . Plant Variety Act (PVA). See U.S. Department of Agri cultur...

Restriction

... sequence s can be used as marker s on physical map s and linkage map s. RFLP is also pronounced "rif" lip. Full article >>> Restriction enzymes were...

Resolution

...lution : Degree of molecular detail on a physical map of DNA , ranging from low to high. Full article...romosome type; used in low- resolution physical map ping to correlate gross chromosomal abnormalities with the character istics ... Full article >...

Repression

...lution : Degree of molecular detail on a physical map of DNA , ranging from low to high. Full article >>> The repression proteins break down the m RNA by removing its "cap" removing its poly(A) tail degrading the remaining message (nibbling away in the 5' -> 3' direction) ....

Reporter Gene

...olution Degree of molecular detail on a physical map of DNA , ranging from low to high. Full article >>> Reporter gene A gene which can be placed downstream of a promoter and expression of the gene followed by a relatively easy assay (often a colorimetric assay). See opero...

Repetitive DNA

...olution Degree of molecular detail on a physical map of DNA , ranging from low to high. Full article >>> repetitive DNA Nucleotide sequence s, usually noncoding, that are present in many copies in a eukaryotic genome . The repeated units may be short and arranged tandemly (in ser...

Recombination frequency

...mbination frequency is used to construct genetic map s. Bacteria are formally haploid and thus don... The mathematical relationship between measured map distance and actual recombination frequency . A formula express ing the relationship between dist...

Recombination

...f how far apart genes are. 1% crossing over = 1 map unit . Example G = gray body ... Full article ...tic marker . Full article >>> Gene map -- the linear arrangement of mutable sites on a chromosome as deduced from genetic recombinatio...

Rare- cutter enzyme

...#62;>> The resulting macro- restriction map s depict the order of and distance between sites at which rare- cutter enzyme s cleave (Fig. 9a: Physical Map ping Strategies: Macrorestriction Map ). Full article >>>...

Quantitative trait loci

...nment . Full article >>> A genetic map of the dog genome will make breed -specific t...rait loci (QTL) ana lysis . Presently, a genetic map of dog consisting of microsatellite marker s is being assembled [1]. Full article >>...

Pyrimidine

...ral form. Full article >>> We first map the whole genomic DNA sequence s following purine - pyrimidine binary rule: change purine s (A/G) to +1 and pyrimidine s (C/T) to -1. This creates a ' DNA walk' along the genome . Full article >>> Transition s (changes from a...

Proximal

...e linked closely. For example 2 gene loci that map to the distal and proximal locations on the long arm of chromosome 1 respectively would not be linked but would ... Full article >>> First, a proximal explanation -- how does it work? And second, an ultimate explanation -- wh...

Post-meiotic segregation

...fferent loci within a gene correlates with the map position of those loci . Full article >>>...

Polymorphism

...ism which results in changes in the restriction map . Other Resources PubMed Google ... Full article >>> Restriction fragment length polymorphism (Redirected from RFLP ) In molecular biology , ... Full article >>> Dr. Francis Collins, director of the National Human...

Physical map

The first pass netted a physical map consisting of 7,700 clusters of overlapping clon...human genome , the lowest- resolution physical map is the banding patterns on the 24 different chromosomes ; the highest- resolution map is the comp...

Phylogeny

...s to class ify an organ ism and to place it on a map of evolution ary relationships known as the phylogenetic tree . Full article >>> Molecular phylogeny is the use of the structure of molecule s to gain information on an organ ism's evolution ary relationships. The result of a ...

Phyla

...s grouped together (singular, phylum ). physical map : a map that locates a gene of interest precisely by showing the actual number of base pair s between gen...

Phosphorylation

... of a phosphate group to a compound . Physical map . A map showing physical locations on a DNA molecule , such as restriction site s, and sequence -tagged...

Phenotypic variance

...y 200 backcross transgenic animals in total to map the QTLs. Full article >>> heritability (in the narrow sense )A measure of the extent to which genes inherited from parents determine phenotype s; defined as the ratio of the additive genetic variance to total phenotypic varianc...

PCR

...ical character istics of an organ ism. Physical map : A map of the locations of identifiable landmarks on DNA , such as genes, or restriction enzyme cutting ...

Overlapping clones

...Clone . Full article >>> A genetic map depicting the relative order of a linked ( cont... , Gene . Full article >>> Contig map s are important because they provide the ability to study a complete, and often large segment of t...

Outbreak

... cholera in London in 1854, John Snow plotted on a map the location of all the cases he learned of. Water in that part of London was pumped from wells located in the various neighborhoods. Full article >>> secondary outbreak . The increase of a nontarget pest to harmful levels following a...

Multiple alleles

... more alternative forms of allelic series that all map to a specific locus Source: Jenkins, John B. 1990. Human Genetics , 2nd Edition. New York: Harper & Row ... Full article >>> Multiple alleles Many genes have more than two alleles (even though any one diploid individual ...

Mouse

...e X chromosome that is closely analogous to the map location for the X-linked human Duchenne muscular dystrophy gene (DMD). Full article >>> Chapter 18 Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogen esis Karen Duff Nathan Kline Institute, ...

Molecular phylogeny

...s to class ify an organ ism and to place it on a map of evolution ary relationships known as the phylogenetic tree . Full article >>> We recently demonstrated that there are at least two ecotypes of Prochlorococcus, each of which is distinguished by its photo physiology and molecular...

Minisatellite

...at of 10 nucleotide s. They are used for genetic map ping. Cf. Full article >>> minisatellite , genetic marker , mobile element, transposon , short interspersed repetitive element, long interspersed repetitive element, junk DNA , variable number tandem repeats , short tandem repe...

Microsatellite

...olymorphic microsatellite marker s for genetic map ping led us to adapt this technique for the detection of PCR amplified microsatellite marker s. Full article >>> The level of expression of the V1a receptor gene is controlled by a " microsatellite " region upstream (5') o...

Methylation

...lication . Mapping : See gene mapping , linkage map , physical map . Marker : Two typical usages: ... Full article >>> : Differing expression of gen...

Mapping

...ene , genome , linkage , nucleotide , physical map ... Full article >>> A technique i...> Mapping : See gene mapping , physical map . Marker : An identifiable physical location on a chromosome (e.g., restriction enzyme cutting ...

Map Unit

...he frequency of crossing over between them; one map unit is equivalent to one percent crossing over ...erms: Map Unit A unit for distance in a linkage map . The distance equal to 1% recombination between two loci . Full article >>> be le...

Marker

...er in bacteria can be used to construct genetic map s. Facts ... Full article >>> Each ...itations. Full article >>> genetic map A diagram showing the position of specific genes along a chromosome relative to marker s. genom...

Map distance

... loci . Recombination can be used to determine map distance between two loci . A map distance of 1 centiMogan (cM) is equivalent to the recombination rate of 1%. Full article >&...

Macrorestriction map

Macrorestriction map Map depicting the order of and distance between... Full article >>> Macrorestriction map s: Top- down mapping . In top- down mapping , a single chromosome is cut (with rare- cutter res...

Loci

... loci . Recombination can be used to determine map distance between two loci . A map distance of 1 centiMogan (cM) is equivalent to the recombination rate of 1%. Full article >&...

Localize

...of an unknown gene on a chromosome or linkage map . Full article >>> Contrast with intermediary metabolism secondary structure The localize d conformation of a protein . sedimentation coefficient A physical constant specifying the rate of sedimentation of a particle in a centr...

Linkage map

Linkage map A genetic map assembled from recombination data that shows the order of mutant sites and genes along a nucle...

Linkage group

...ns fer of a linkage group . gene linkage map: a map that pinpoints the location of genes based on their connection to certain marker gene sequence s. Full article >>>...

Linkage

... article >>> Linkage and physical map ping goals engendered the most discussion. With respect to linkage map s of each human chromosome , advisors agreed that for the next 5-year period, ... Full article &...

Library

...ship to each other can be established by physical map ping. Compare genomic library , arrayed library . Related Terms: Clone bank ... Full article >>> Library Instruction Round Table LITA Library and Information Technology Association ... Full article >>> libra...