... (1994) "Recruitment of long-lasting and protein kinase
A-dependent long-term potentiation in the CA1 ... "A requirement for the mitogen-activated protein kinase
cascade in hippocampal long term potentiation". ...
^ Sweatt JD (2001) "The neuronal MAP kinase
cascade: a biochemical signal integration system ...
... reaching the normal size ( wee mutants). The Wee1 protein is a tyrosine kinase
. It normally phosphorylates the Cdc2 cell cycle regulatory protein on a ... size regulation in mammals
The protein mTOR is a serine/threonine kinase
that regulates translation and cell division. Nutrient availability ...
... forming 1,3-bisphosphoglycerate.
In the next step, phosphoglycerate kinase
generates a molecule of ATP while forming 3-phosphoglycerate. At this step ... of pyruvate and a molecule of ATP by means of the enzyme pyruvate kinase
. This serves as an additional regulatory step.
After the formation of ...
... /rigidity, myoclonus (twitching) and myalgia (muscle pain). Diagnostic procedures that may reveal muscular disorders include testing creatine kinase
levels in the blood and electromyography (measuring electrical activity in muscles).
Neuromuscular diseases are those that affect the muscles ...
... roles in cellular energy transport and transformations (notably ATP and NAD+/NADH ), and in enzyme regulation (see for example, protein kinase
The nucleobase can be a purines or pyrimidines , the sugar can be deoxyribose in DNA or ribose in RNA, and the phosphate chain can be a ...
... GTPases , for example, the Ras protein .
Cytoplasmic Serine / Threonine kinases and their regulatory subunits , for example, the Raf kinase
, and cyclin-dependent kinases (through overexpression ).
Adaptor proteins in signal transduction .
Transcription factors .
... A also phosphorylates C directly, and B can phosphorylate D, which may in turn phosphorylate A.
Types of phosphorylation
See also protein kinase
for more details on the different types of phosphorylation
Within a protein, phosphorylation can occur on several amino acids . Phosphorylation ...
... the regulation of calmodulin by Ca 2+ . Calmodulin itself can regulate other proteins, or be part of a larger protein (for example, phosphorylase kinase
). The Ca 2+ /calmodulin complex plays an important role in proliferation, mitosis and neural signal transduction.
Lipophilic second ...
... in turn send the signal along a signal chain to its destination.
The intracellular domain has enzymatic activity . Often, this is a tyrosine kinase
activity. The enzymatic activity can also be located on an enzyme associated with the intracellular domain.
Regulation of receptor activity