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terna Zentaris Discloses First In Vitro Data for its PI3K,,,Inhibitors at the AACR Annual Meeting in Los Angeles

-list: l0 level1 lfo1; tab-stops: list .5in"> Novel low molecular weight kinase inhibitor

Excellent in vitro activity against PI3K

High selectivity against a panel of more than 50 kinases

Anti-proliferative efficacy in diverse tumor cell-lines

Promising bioavailability observed for lead compound

PI3K signalling network covers enormous therapeutic potential

We are pleased with these results which exemplify our capability of developing novel therapeutic approaches that add to the breadth and depth of our product pipeline, said Dr Jrgen Engel, Executive Vice President, Global R&D and Chief Operating Officer at terna Zentaris. The potential for cancer treatment with agents inhibiting the PI3K pathway has become a focus in recent drug discovery and development research. We believe that by developing novel selective PI3K inhibiting small molecular compounds, we are positioning ourselves as one of the leaders in this promising therapeutic approach.

Cellular substrate phosphorylation studies targeting the inhibition of PI3K and functional cellular assays of tumor cell proliferation have been performed. In addition, physicochemical and initial ADMET data were
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