Navigation Links
terna Zentaris Discloses First In Vitro Data for its PI3K,,,Inhibitors at the AACR Annual Meeting in Los Angeles

Second generation pyridopyrazine-urea derivative compound series show highly selective PI3K-inhibition which could be valuable for cancer treatment

QUBEC CITY, Canada, April 16, 2007 terna Zentaris Inc. (TSX: AEZ; Nasdaq: AEZS), a global, pure play biopharmaceutical company focused on endocrine therapy and oncology, today presented an abstract outlining first in vitro data on its pyridopyrazine derivatives with high selectivity for PI3K inhibition, at the American Association for Cancer Research (AACR) Annual Meeting being held this week at the Los Angeles Convention Center in Los Angeles, California.

Results

The poster #2379 entitled, New Generation of Anilino-Substituted Pyridopyrazine-Urea Derivatives Show Highly Selective PI3K-Inhibition, reviewed for the first time, results for a preclinical development program on a new generation of pyridopyrazine derivatives which clearly indicate that these drug candidates selectively inhibit PI3K.

Furthermore, an optimization process of our already known aryl-pyridopyrazine series led to the identification of a new lead compound in this series. A medicinal chemistry program was then initiated which resulted in the synthesis of new anilino-substituted pyridopyrazines. Out of this second generation series, several derivatives also with highly-selective PI3K inhibition as well as improved cellular efficacy and better drug-like properties, were identified.

Conclusions






Page: 1 2 3 4

Related medicine technology :

1. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
4. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
6. Suven Life Sciences Presenting Pre-clinical data of their NCE’s SUVN-502 and SUVN-507at International Brain Research Organization (IBRO) 2007 World Congress of Neuroscience
7. Nuvelo Announces Presentations on rNAPc2 and NU172 at the XXIst Congress of the International Society on Thrombosis and Haemostasis
8. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
9. Labopharm to Present Poster on Dose Titration of Once-daily Tramadol at 3rd International Forum on Pain Medicine
10. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
11. Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Childrens Hospital and Stanford
Post Your Comments:
(Date:4/24/2015)... , April 24, 2015 ... portfolio of automated, indication-specific planning tools for radiosurgery/SBRT ... focused software applications aimed at enhancing the workflow ... and spine introduced in 2013 - comes full ... (SRS) planning tools. These new Elements enable on-the-fly ...
(Date:4/24/2015)... , April 24, 2015 The ... (part of the National Institutes of Health [NIH])  ... nine research projects for the development of diagnostic ... recent HAI outbreaks at U.S. health facilities , ... research into rapid, multiplexed and effective tests using ...
(Date:4/24/2015)... , April 24, 2015  Lannett Company, Inc. ... amended and increased its five-year revolving credit facility to ... an accordion feature that will allow the company to ... additional $30.0 million, subject to securing additional commitments from ... of the credit facility remains December 18, 2018.   ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2Kalorama: NIAID Rewards HAI Innovators with Grants 2Kalorama: NIAID Rewards HAI Innovators with Grants 3Kalorama: NIAID Rewards HAI Innovators with Grants 4Lannett Expands Revolving Credit Facility To $120 Million 2
... 10, 2012 Elsevier, a world-leading provider ... announced it will organize an extra Tetrahedron Symposium in ... speakers in bioorganic and organic medicinal chemistry closer to ... in two locations, one in Europe and one in ...
... The Ministry of Health and Welfare and Korea Health Industry ... Health Authority-Abu Dhabi (HAAD) arrived in South Korea on Dec. ... government arranged for domestic hospitals to sign a pact on ... Chairman Mohammed Sultan Al Hameli and CEO Zaid Daoud Al ...
Cached Medicine Technology:Elsevier Announces Two Tetrahedron Symposia for 2012 2Elsevier Announces Two Tetrahedron Symposia for 2012 3First Patient from Abu Dhabi Arrives in South Korea for Medical Treatment 2
(Date:4/24/2015)... On February 21st, 2015, Per Wickstrom had the ... contributor Karen Salkin at Durkin Entertainment’s EcoLuxe Lounge, sponsored ... of which Wickstrom is the founder. Making appearances at ... EcoLuxe Lounge is a gathering of some of the ... and services. Among the many roles that she has ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 With years ... , UGA is now proud to be partnered with ... of 16,000 animals a year. This partnership has brought ... their animals. , After providing an in-house payment ... Medical Teaching Hospital (VMTH) wanted to increase financing options ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 “ Opera ” ... Report, which features the latest and coolest technology products available ... of NewsWatch, conducted the review and shared with viewers how ... Without web browsers, surfing the internet would not be in ... other and the Opera browser is no different. Celebrating their ...
(Date:4/24/2015)... April 24, 2015 Qualis Health, ... organizations, has published a new resource for practicing ... The guide to Quality and Resource Use Reports ... & Medicare Services (CMS) to help practices interpret ... streamline resources, and identify care coordination opportunities to ...
Breaking Medicine News(10 mins):Health News:Karen Salkin Talks with Per Wickstrom at the 2015 EcoLuxe Lounge and the "Salute to the Oscars" Celebration 2Health News:University of Missouri Veterinary Medical Teaching Hospital Teams with UGA 2Health News:A Web Browser That Connects over 350 Million People was Featured on NewsWatch Television 2Health News:Qualis Health Publishes Guide to Help Physician Practices Assess and Improve Quality 2
... variants in the DNA of 486 people infected with HIV that ... virus and delay the onset of full-blown AIDS. ... for an HIV vaccine that would work by boosting the protective ... bodys own immune system overcome an infection. One of the genes ...
... may have ended 150 years ago but that need not ... ambience in a majestic 17th century garden . ... has made known plans to open up a part of ... for weddings. ,The magnificently laid and maintained gardens, ...
... passed snide remarks about her, claiming that the actress is too ... Ashton Kutcher tied the knot in September 2005, and the actress ... ,Lesley Guynes, who is separated from Moores half-brother commented that the ... she was old. ,I think Demi is getting too ...
... study by researchers has claimed that Chinas desire to ... monkeys in their infancy in the Mount Huangshan Scenic ... ,According to National Geographic, the skyrocketing infant mortality of ... to a restricted range and regularly competing for corn ...
... toughen anti-smoking laws, restricting smoking in public places and ... further approved a Health and Family Welfare Ministry proposal ... Act in the first week of the monsoon session ... told reporters after a Cabinet meeting in New Delhi. ...
... food cravings and keeping them in check may be ... first six-month phase of the study provides new insights ... their role in weight control. ,Cravings are ... Susan Roberts, PhD, director of the USDA HNRCAs Energy ...
Cached Medicine News:Health News:Experts Identify Vaccine Target for HIV 2Health News:Experts Identify Vaccine Target for HIV 3Health News:Now You can Marry in a Mughal Ambience, If You Wish to 2Health News:Chinese Eco-tourism Causing Infanticide Among Tibetan Monkeys 2Health News:Government to Toughen Its Anti-smoking Laws 2Health News:Weight Management Achieved by Controlling and Not Suppressing Food Cravings 2
... BP 900 offers three magnifications ... routine practice, the BP 900 ... and progressive functionality. Two optional ... one for digital photography, are ...
... 400 System is an automated multiplexing platform ... SNP detection, pathogen sequence detection and pharmacogenetics ... be applied to an open and flexible ... be reused until all tests sites have ...
... for venous pressure monitoring, blood sampling, ... Turbo-Flo polyurethane PICC line sets offer:, ... Micropuncture Introducer Needle, Biocompatible ... trimmed to patient specific anatomy. Remove ...
Cable connections for 5 different adapters: Storz, ACMI, Pentax, Wolf and Olympus....
Medicine Products: