( ks and uncertainties include but are n...)Shire to Present New Scientific Data on ADHD Treatment Portfolio at,APA Annual Meeting,Health

ks and uncertainties include, but are not limited to, risks associated with: the inherent uncertainty of pharmaceutical research, product development, manufacturing and commercialization; the impact of competitive products, including, but not limited to the impact of those on Shire's Attention Deficit and Hyperactivity Disorder ("ADHD") franchise; patents, including but not limited to, legal challenges relating to Shire's ADHD franchise; government regulation and approval, including but not limited to the expected product approval dates of SPD503 (guanfacine extended release) (ADHD) and SPD465 (extended release triple-bead mixed amphetamine salts) (ADHD); Shire's ability to secure new products for commercialization and/or development; Shire's ability to benefit from its acquisition of New River Pharmaceuticals Inc.; and other risks and uncertainties detailed from time to time in Shire plc's filings with the Securities and Exchange Commission, particularly Shire plc's Annual Report on Form 10-K for the year ended December 31, 2006.

CONTACT: Marion E. Glick , +1-212-601-8273, or +1-917-301-4206 (on site atAPA), or Jacelyn Seng, +1-212-601-8385, or +1-917-392-0756 (on site atAPA), both of Porter Novelli for Shire

Web site: http://www.shire.com/

Ticker Symbol: (NASDAQ-NMS:SHPGY)

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