Navigation Links
ZIOPHARM Presents Unique Mechanism Data for Indibulin at AACR

LOS ANGELES--(BUSINESS WIRE)--Apr 16, 2007 - ZIOPHARM Oncology, Inc. (NASDAQ: ZIOP) presented preclinical data yesterday on indibulin (ZIO-301) at the American Association of Cancer Research (AACR) meeting in Los Angeles. These data demonstrate that indibulin has distinct biologic and molecular properties from other tubulin binding agents and strongly suggest a very different toxicity profile, particularly with regard to peripheral neuropathy. While indibulin binds to tubulin in general, it does not bind to neuronal specific tubulin and does not disrupt normal axonal microtubules in vitro, likely accounting for the difference with regard to neurotoxicity.

Indibulin is one of a class of cancer therapeutics that includes the taxanes (paclitaxel and docetaxel) and Vinca alkaloids, some of the most widely used anti-cancer agents in the world today. In spite of their effectiveness, all of the commercially available agents exhibit some degree of neurotoxicity that in many cases can be dose limiting.

Indibulin, like the taxanes and vinca alkaloids, interferes with the function of microtubules by binding to their building blocks, tubulin. However, the specific tubulin binding site for indibulin is different from that of taxanes and Vinca alkaloids. The observed lack of neurotoxicity in animals receiving indibulin treatment is thought to be related to this difference in binding site, and in particular to the observation that indibulin does not bind to neuronal-specific tubulin. Indibulin is active across a diverse range of human, mouse, and rat tumor cell lines in vitro and in human tumor xenografts, including glioblastoma and in drug-resistant tumor cell lines.

"We are very excited about indibulin's potential," commented Brian Schwartz, M.D., Chief Medical Officer at ZIOPHARM. "The fact that it is orally available and shows no signs of the neurotoxicity in preclinical models associated with other agents i
'"/>




Page: 1 2 3

Related medicine technology :

1. ZIOPHARM to Present at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
2. ZIOPHARM Presents Data Highlighting Oral ZIO-101 at AACR
3. ZIOPHARM Presents Data on Orally Active ZIO-201 at AACR
4. ZIOPHARM Presents ZIO-201 Lymphoma Data at ISH
5. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
6. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
7. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
8. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
9. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
10. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
11. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: ZIOPHARM Presents Unique Mechanism Data for Indibulin AACR
(Date:7/11/2014)... N.C. , July 11, 2014 ... approaches are evolving across industry sectors to better ... examining better ways to engage with and understand ... inform themselves and make critical purchasing decisions. ... firm, Best Practices, LLC, one area where organizations ...
(Date:7/11/2014)...  Kindred Hospital Houston Northwest, with Wound Care ... its new outpatient wound healing center.  The wound ... chronic, hard to heal wounds. Chronic wounds include ... lower leg wounds related to blood flow issues, ... injury wounds which are complex and demonstrate delayed ...
(Date:7/11/2014)... LOUIS , July 11, 2014 /PRNewswire/ ... device company, announced today the positive, cost-effective ... its innovative SPiNPerc™ procedure. The SPiNPerc endobronchial ... of a percutaneous approach to biopsy when ... Hospitals, patients and physicians experience positive financial ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Veran Medical Publishes Lung Cancer Patient Management Study 2
... WASHINGTON, Nov. 2, 2011 The Long Term Care ... by the Centers for Medicare and Medicaid Services (CMS) ... as a consideration of the Conditions of Participation for ... Our member companies and individual pharmacists have ...
... AMSTERDAM, November 2, 2011 Elsevier, ... information products and services, announced today that its ... purchase on SciVerse ScienceDirect, Elsevier,s online platform for ... in the breadth and depth of the eBook ...
Cached Medicine Technology:Proposed CMS Changes Related to Consultant Pharmacists Raise Profound Concerns for Pharmacies 2Elsevier Announces New 2012 Frontlist eBooks Collection on SciVerse ScienceDirect Available for Advance Purchase 2Elsevier Announces New 2012 Frontlist eBooks Collection on SciVerse ScienceDirect Available for Advance Purchase 3
(Date:7/11/2014)... 11, 2014 Ticket Down reports that tickets ... and 3rd place World Cup Match between Brazil and ... will take place on Saturday, July 12th at Estadio Nacional ... Finals will take place on Sunday, July 13th at Estadio ... All tickets for the 2014 World Cup are guaranteed to ...
(Date:7/11/2014)... July 11, 2014 (HealthDay News) -- Reducing the number ... incidence of Lyme disease and other tick-borne infections among ... deer populations can be manipulated to reduce human interactions ... contracting Lyme disease," the researchers wrote. White-tailed deer ... transmit Lyme disease to people. The study included ...
(Date:7/11/2014)... 11, 2014 Volunteers from Scientology ... abuse this week with drug education lectures, forums and ... distribution in cities around the world. , Drug abuse ... Institute on Drug Abuse, abuse of alcohol and illicit ... crime, lost work, decreased productivity and healthcare. , ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 The ... by Types, Applications & Geography - 2018,” defines ... fiber market with an analysis and forecast of ... specialty synthetic fibers (Para aramids, meta aramids, UHMW ... others including PPS fiber, PBI fiber, PBO fiber, ...
(Date:7/11/2014)... 11, 2014 Utilizing the Keller Funnel, ... William Koenig, has topped a record number of complication-free ... performed over 400 successful procedures without the occurrence of ... well known across the country for his expertise with ... has long been the foundation for numerous studies and ...
Breaking Medicine News(10 mins):Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2Health News:Scientologists Taking Action against Drug Abuse 2Health News:Scientologists Taking Action against Drug Abuse 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2
... ... ... ... ...
... , ... ... ... ...
... ... ... , ... , , ...
... ... ... , , ... WASHINGTON , ...
... type of blood cancer, mixed lineage leukemia (MLL), has an ... cells rely on the normal version of an associated protein ... of chromosome 11 breaks off at the normal MLL-associated gene. ... a fusion protein that eventually causes uncontrolled growth of blood ...
... ... Health Systems. The Meaningful Use Dashboard will provide a single location where an organization ... Indicators. , ... OH (PRWEB) February 26, 2010 -- Health Care DataWorks , a Technology Company ...
Cached Medicine News:Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 2Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 3Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 4Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 5Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 6Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 7Health News:Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case 8Health News:CPR Instruction Via Cell Phone Effective 2Health News:CPR Instruction Via Cell Phone Effective 3Health News:CPR Instruction Via Cell Phone Effective 4Health News:Fifth Anniversary of Global Tobacco Control Treaty Presents Opportunity For U.S. Ratification and Leadership 2Health News:Fifth Anniversary of Global Tobacco Control Treaty Presents Opportunity For U.S. Ratification and Leadership 3Health News:Fifth Anniversary of Global Tobacco Control Treaty Presents Opportunity For U.S. Ratification and Leadership 4Health News:Two Atlanta-Based Nursing Home Chains and Their Principals Pay $14 Million to Settle False Claims Act Case 2Health News:Two Atlanta-Based Nursing Home Chains and Their Principals Pay $14 Million to Settle False Claims Act Case 3Health News:Two Atlanta-Based Nursing Home Chains and Their Principals Pay $14 Million to Settle False Claims Act Case 4Health News:Two Atlanta-Based Nursing Home Chains and Their Principals Pay $14 Million to Settle False Claims Act Case 5Health News:Cells of aggressive leukemia hijack normal protein to grow 2Health News:HCD Announces Meaningful Use Dashboard for Health Systems 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: