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ZIOPHARM Presents Data Highlighting Oral ZIO-101 at AACR

LOS ANGELES--(BUSINESS WIRE)--Apr 17, 2007 - ZIOPHARM Oncology, Inc. (NASDAQ: ZIOP) announced today the presentation of preclinical data strongly supportive of the development of an oral form of ZIO-101. Specifically, ZIO-101 demonstrates very high bioavailability when administered orally; in addition it evidences anti-angiogenic activity that is particularly well suited to oral administration. These data were presented in two separate posters today at the American Association of Cancer Research (AACR) meeting being held in Los Angeles.

Philip Komarnitsky, M.D., Ph.D., of ZIOPHARM, and colleagues presented data showing that the administration of ZIO-101 results in dramatically reduced new blood vessel formation in a mouse model of angiogenesis. Anti-angiogenic therapy that utilizes lower doses of the administered drug given over sustained periods of time is particularly well suited to drugs that can be orally administered. Data from pharmacokinetic analysis of orally administered ZIO-101 in animals showed very high bioavailability.

Lawrence Boise, Ph.D., from the University of Miami, and colleagues also presented additional data supporting a ZIO-101 mechanism of action that is distinct from that of arsenic trioxide, an inorganic arsenic that is currently approved for the treatment of a rare form of leukemia and used in the treatment of advanced multiple myeloma. Differences in the way the two drugs activate genes and in their mechanisms of action suggest that ZIO-101 is likely to be active against cancer cells that are resistant to arsenic trioxide.

"These preclinical data are strongly supportive of the Company's development strategy for both oral and IV ZIO-101," commented Jonathan Lewis, M.D., Ph.D., Chief Executive Officer. "ZIO-101 is currently in three separate phase II trials in blood and solid cancers and we expect to initiate clinical study with an oral form in the second half of 2007."'"/>




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