( omes ever clearer thatprogressive step...)ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data,Presented at International Myeloma Workshop,Health

omes ever clearer that progressive steps in the treatment of myeloma are going to be made with agents that are complimentary to the current standard of care," commented Dr. Berenson. "With its unique mechanism of action, coupled with a continued benign safety profile, we are hopeful that darinaparsin will find a place in our treatment armamentarium."

Preclinical studies in myeloma cell lines have indicated synergy of darinaparsin with Velcade(R), which would serve as the basis for exploring the use of darinaparsin in a combination clinical study. This study is in the advanced stages of planning. The Company is also in late stage planning to extend the twice weekly myeloma trial to Eastern Europe in order to treat patients with less advanced disease.

ZIOPHARM is also enrolling patients in phase II trials of darinaparsin for the treatment of primary liver cancer and diverse hematological cancers. Phase I trials with an oral form of darinaparsin are expected to be underway soon. For more details on these trials please see www.clinicaltrials.gov.

About Darinaparsin (ZIO-101)

Darinaparsin is a proprietary small molecule organic arsenic licensed from The University of Texas M. D. Anderson Cancer Center and Texas A&M University. Darinaparsin induces cell cycle arrest and cell death by targeting several cellular pathways essential for cell survival. Exposure to darinaparsin has a direct as well as indirect effect on mitochondrial functions, resulting in depletion of energy supply to the cell and induction of apoptosis (programmed cell death). Increase in intra-cellular Reactive Oxygen Species enhances this effect on mitochondrial functions and consequently the activation of the signal transduction pathway leading to apoptosis. In addition, darinaparsin interrupts the cell cycle at the G2/M phase of tumor cells inducing cell death through this pathway.

About ZIOPHARM Oncology, Inc.

ZIOPHARM Oncology, Inc. is a biopharmaceutical c
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