Navigation Links
Xanthus Presents Novel Approach for Autoimmune Disease Reversal,with Symadex

CAMBRIDGE, Mass.--(BUSINESS WIRE)--May 3, 2007 - Xanthus Pharmaceuticals, Inc today presented data demonstrating that Symadex(TM) reversed the clinical and pathological signs of chronic disease in an animal model for multiple sclerosis. The presentation was made by Stephen J. Karlik, Ph.D., Professor of Diagnostic Radiology at the University of Western Ontario, London, Ontario, together with researchers from Xanthus in a poster session at the 59th American Academy of Neurology Meeting in Boston, MA.

Using a model of experimental autoimmune encephalomyelitis (EAE) that is designed to represent multiple sclerosis, Dr. Karlik tested Symadex for its effect on both acute and chronic disease. In the acute EAE model, animals treated with Symadex substantially recovered while in control animals the disease symptoms and damage remained unchanged. In chronic EAE disease models, clinical and pathological disease reversal and tissue recovery were observed with Symadex treatment. At the same time, Symadex did not affect circulating immune cell numbers, suggesting that it does not act as a general immunosuppressant.

"Symadex' ability to reverse chronic autoimmune disease in this animal model is notable. The study results suggest this activity may result from inhibiting macrophage function rather than inhibiting T cell function. This mechanism is novel in my experience," said Dr. Karlik.

"We now have a significant body of promising preclinical data supporting the use of Symadex in multiple autoimmune indications. We believe this represents a strong partnering opportunity for our Company, and we are preparing to initiate a human proof-of-principle trial with Symadex in autoimmune disease," stated Richard T. Dean, Ph.D., Xanthus' Chief Executive Officer.

About Symadex(TM)

Symadex (formerly C-1311) is the lead compound from a new series of agents, the imidazoacridinones, which have been shown to be po
'"/>




Page: 1 2 3

Related medicine technology :

1. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
2. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
3. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
4. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
5. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
6. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
7. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
8. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
9. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
10. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
11. BioCryst Presents Phase I Peramivir Data at the Options for the Control of Influenza Conference
Post Your Comments:
(Date:11/26/2014)... November 25, 2014 According ... by Power Source (Electric, Battery, Pneumatic), by Product ... Burr, Cart), by Application (Orthopedic, ENT, Oral, Thoracic, ... MarketsandMarkets, the global Powered Surgical Instruments Market is estimated ... in 2014 and is expected to grow at ...
(Date:11/26/2014)... 2014 Nanomix Inc., (Nanomix), a ... of mobile diagnostic tests to enable earlier ... pre-hospital settings, today announced it has received ... certification was awarded by the British Standards ... certification bodies. ISO 13485:2003 ...
(Date:11/26/2014)... THOUSAND OAKS, Calif. and LONDON ... AMGN ) and AstraZeneca (NYSE: AZN ) today ... trial evaluating two doses of brodalumab in more than 1,800 ... compared with both Stelara ® (ustekinumab) and placebo at ... the brodalumab weight-based analysis group were each shown to be ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Nanomix Receives ISO 13485:2003 Certification 2Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 2Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 3Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 4Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 5Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 6Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 7Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 8Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 9Amgen And AstraZeneca Announce Positive Results From Third And Final Pivotal Phase 3 Study Of Brodalumab In Patients With Moderate-To-Severe Plaque Psoriasis 10
... N.J., Dec. 22, 2011  Ikaria, Inc. announced today that ... DS drug-delivery systems related to a fretting corrosion.  This ... direction of the U.S. Food and Drug Administration (FDA).  ... a reasonable likelihood of serious adverse health consequences or ...
... 2011 ViroPharma Incorporated (NASDAQ: VPHM ) today ... acquire Meritage Pharma, Inc., a private company based in San ... a treatment for eosinophilic esophagitis (EoE), a chronic inflammatory disorder ... initial $7.5 million, and has agreed to provide Meritage up ...
Cached Medicine Technology:Ikaria® Issues Notice of Completed Remediation for INOMAX® DS Drug-delivery System 2Ikaria® Issues Notice of Completed Remediation for INOMAX® DS Drug-delivery System 3ViroPharma Purchases Exclusive Option to Acquire Meritage Pharma 2ViroPharma Purchases Exclusive Option to Acquire Meritage Pharma 3ViroPharma Purchases Exclusive Option to Acquire Meritage Pharma 4ViroPharma Purchases Exclusive Option to Acquire Meritage Pharma 5ViroPharma Purchases Exclusive Option to Acquire Meritage Pharma 6ViroPharma Purchases Exclusive Option to Acquire Meritage Pharma 7
(Date:11/27/2014)... In order to enable people to adapt to the ... way to avoid touching a toilet seat and/or lid while ... of the patent-pending Toilet Tamer, a device that enables a ... in a more sanitary manner. It avoids direct contact with ... promotes good hygiene and peace of mind. The portable device ...
(Date:11/27/2014)... 27, 2014 Now that Thanksgiving is ... officially launched, Emassagechair.com has announced its eagerly ... Event. , Negotiating on behalf of their customers, ... chair brands, Emassagechair.com has generated significant buzz in the ... biggest discounts yet. , Shoppers are excited for significant ...
(Date:11/27/2014)... VogueQueen.com is making every effort to offer more ... As the premier online supplier of elegant special occasion ... a huge selection of sexy prom dresses today. In ... providing many beautiful styles in its product line. Click ... prices. , “VogueQueen.com hopes to provide a truly unique ...
(Date:11/27/2014)... Developers and plugin specialist of Final Cut ... taking FCPX to the next level. , “ProPip allows users ... clicks of a mouse,” said Christina Austin, CEO of Pixel ... will appreciate.” , With ProPip users can show off their ... endless. ProPip is great for commentaries, news casting, and more. ...
(Date:11/27/2014)... November 27, 2014 HealthPostures, a ... ergonomics equipment , has announced that it has ... Office Environments. The partnership will put HealthPostures' products ... location. , In addition to having its products ... partnership promotes HealthPostures' products with the business decision ...
Breaking Medicine News(10 mins):Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 2Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 3Health News:Emassagechair.com is Excited to Announce Their Biggest Discount Event of the Year, Starting the Day After Thanksgiving and Lasting Through The Holiday Weekend. 4Health News:A New Collection of Sexy Prom Dresses Has Been Released by the Reliable Online Supplier VogueQueen.com 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 2Health News:Pixel Film Studios released ProPip plugin Exclusively for Final Cut Pro X 3Health News:Ergonomics Manufacturer Announces New Partnership with Office Supply Dealer 2
... and Development, RESTON, Va., Feb. 4 ... that Donald W. Hackett, chief executive,officer, has left ... Bruce Roberts, RPh, executive vice president and ... chairman of Mirixa,s board of,directors, expressed appreciation for ...
... May Help Protect Your Heart, LANSING, Mich., Feb. ... mantras for promoting heart-health during February,American Heart Month. But ... red to protect our hearts. Americans are encouraged to ... first-ever National,Eat Red Week, Feb. 4-10., Why eat ...
... OTTAWA, Feb. 4 Sports and,nutritional product ... http://www.naturalnutritioninc.com primary operating subsidiary,InterACTIVE Nutrition, ... increase,in 2007 revenues over the calendar year ... (CDN) versus 2007 unaudited revenues of $17,460,780,(CDN)., ...
... Simcere Pharmaceutical,Group (NYSE: SCR ), a leading ... anti-cancer pharmaceuticals in the rapidly,growing China market, announced ... quarter results on Tuesday, March 4, 2008 before ... executive officer, Jinsheng Ren, and,chief financial officer, Frank ...
... SAN ANTONIO, Feb. 3 Noticing a few extra hairs ... trying to conceal areas of,thinning hair rather than a fashion ... promoting hair growth? If you answered,yes to any of these ... some form of hair loss. But to whom should you ...
... prove anecdotes that canines can smell dangerous drops in blood ... researchers hope to prove that a dog,s keen sense of ... sugar levels of diabetics. , Canines have already shown themselves ... the physically disabled with daily tasks. , But researchers at ...
Cached Medicine News:Health News:Mirixa Corporation Announces Leadership Change 2Health News:Celebrate American Heart Month by Eating Red 2Health News:Celebrate American Heart Month by Eating Red 3Health News:Natural Nutrition Operating Subsidiary Reports Record 29% Increase in Revenues for 2007 of $17,460,000 2Health News:Simcere Pharmaceutical Group to Announce Fourth Quarter 2007 Earnings on Tuesday, March 4, 2008 2Health News:Don't Let Hair Loss Tangle You Up: Dermatologists Can Identify Common Hair Disorders and Offer Solutions 2Health News:Don't Let Hair Loss Tangle You Up: Dermatologists Can Identify Common Hair Disorders and Offer Solutions 3Health News:Don't Let Hair Loss Tangle You Up: Dermatologists Can Identify Common Hair Disorders and Offer Solutions 4Health News:Don't Let Hair Loss Tangle You Up: Dermatologists Can Identify Common Hair Disorders and Offer Solutions 5Health News:Don't Let Hair Loss Tangle You Up: Dermatologists Can Identify Common Hair Disorders and Offer Solutions 6Health News:Dogs Could Be a Diabetic's Best Friend 2Health News:Dogs Could Be a Diabetic's Best Friend 3Health News:Dogs Could Be a Diabetic's Best Friend 4
...
EDM Ventricular Drainage Kit, with Drip Chamber with and without Bioglide are fabricated of radiopaque (barium impregnated) silicone tubing, and are packaged with stainless steel stylets inserted in ...
Lumbar External Drainage System (LED) with Touhy needle is indicated for temporary access to the Lumbar Subarachnoid region as a means of draining cerebral spinal fluid (CSF) in order to reduce incre...
Monitorr ICP external CSF drainage and monitoring system with patient line one way valve....
Medicine Products: