Navigation Links
Weight Management is Not Enough for Cannabinoid Type 1 (CB1),Receptor Antagonists to Become a Commercial Success

Huge clinical development program of first-in-class CB1 antagonist rimonabant to show benefits beyond weight reduction and avoid image as life-style drug

BARCELONA, Spain | March 08, 2007 | The Business Intelligence firm La Merie S.L. reported today that Sanofi-Aventis’ first-in-class CB1 antagonist Acomplia (rimonabant) has at least five competitors in clinical stages up to phase III and many more in earlier phases of R&D. While Acomplia received EU approval in June 2006, the FDA requested more time to review the file. Acomplia is indicated for the treatment of patients with obesity or overweight plus cardiometabolic risk factors and achieved EU sales of € 31 mln in its first months in selected markets. However, some countries such as Germany consider Acomplia as a non-reimbursable life-style drug. Sanofi-Aventis is undertaking a huge clinical program to profile Acomplia in additional populations such as in type 2 diabetes (1st line), insulinized patients, dyslipidemia or atherosclerosis. Another field of potential use of CB1 antagonists lies in neuroscience, such as addiction and cognitive disorders. These results and more were found in a search conducted by La Merie Business Intelligence. The competitor analysis of CB1 antagonists can be acquired at www.pipelinereview.com, La Merie’s News Center and Online Store.

Rimonabant has been studied in more than 6,000 patients. Results of the RIO-LIPIDS study showed that a one-year treatment of overweight and obese patients with abnormal lipid levels with once daily rimonabant significantly reduced body weigth by an average of 6.9 kg in comparison to a loss of 1.5 kg in the placebo group. More importantly, it improved a range of cardiometabolic risk factors that may contribute to type 2 diabetes and heart disease. Results of a two-year treatment with rimonabant in the RIO-
'"/>




Page: 1 2 3

Related medicine technology :

1. Elixir Pharmaceuticals Presents Additional Preclinical Data Demonstrating the Potential of Ghrelin Antagonism to Regulate Metabolism, Body Weight and Glycemic Control
2. Breaking Multi-Center Study: Masimo SET Pulse Oximetry Technology Shown to Significantly Lower Instances of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants
3. New Data Show Xenical Significantly Reduces Cardiovascular Risk and More Than Doubles Weight Loss Achieved in Overweight and Obese People
4. New Data Confirm That Use of Levemir Can Limit Weight Gain
5. Safety Analyses of Clinical Data for Bifeprunox in Patients with Schizophrenia Showed a Favorable Weight and Lipid Profile, Similar to Placebo
6. Choosing Lab Quality Management Software
7. Optimizing Quality Control Data Management
8. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
9. Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits
10. Vakzine Projekt Management Reports Positive Clinical Trial Results With Their Therapeutic Prostate Cancer Vaccine VPM4001
11. Oculus Innovative Sciences Microcyn Technology Presented in Poster at European Wound Management Association Conference

Post Your Comments:
(Date:11/30/2009)...wswire/ -- Reportlinker.com announces that a new m...e: ,, Inflammatory Disorders: Therapies That S...p://www.reportlinker.com/p0165600/Inflammatory-Dis...ne-Response.html ,, The human immune system ca...producing an exaggerated response to a foreign sub...
(Date:11/30/2009)... According to Millennium Research ...ology market intelligence, the nearly $1.2 billion...t 5% over 2008 as patients chose to delay or foreg...e market will, however, begin recovery in 2010, an... growth rates of over 15%. MRG,s facial injectable...
(Date:11/30/2009)... 30 Today at the 95th Scientific A...ociety of North America (RSNA), Bayer HealthCare P...e first patient in an international Phase III clin...florbetaben (BAY 94-9172) PET imaging in the detec...re a pathological hallmark of Alzheimer,s disease....
Breaking Medicine Technology:Reportlinker Adds Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response 2Reportlinker Adds Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response 3Reportlinker Adds Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response 4Reportlinker Adds Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response 5Facial Injectables Emerge From the Recession 2Facial Injectables Emerge From the Recession 3Bayer HealthCare Pharmaceuticals Initiates Phase III Trial with Florbetaben PET Tracer for Imaging of Cerebral beta-Amyloid Plaques, a Pathological Hallmark of Alzheimer's Disease 2Bayer HealthCare Pharmaceuticals Initiates Phase III Trial with Florbetaben PET Tracer for Imaging of Cerebral beta-Amyloid Plaques, a Pathological Hallmark of Alzheimer's Disease 3Kaiser Permanente Debuts New Ads Focused on Technology and Innovation 55897 1Kaiser Permanente Debuts New Ads Focused on Technology and Innovation 55897 2Kaiser Permanente Debuts New Ads Focused on Technology and Innovation 55897 3Employers Launch Grassroots Health Reform Coalition 55895 1Employers Launch Grassroots Health Reform Coalition 55895 2Employers Launch Grassroots Health Reform Coalition 55895 3Monsanto Licenses Use of Cellectis Innovative Genome Modification Technology 13776 1Monsanto Licenses Use of Cellectis Innovative Genome Modification Technology 13776 2Monsanto Licenses Use of Cellectis Innovative Genome Modification Technology 13776 3
...,(Nasdaq: ACEL ) today announced it has confirmed...ccurred in the Phase IIIb clinical trial of its le...ts with unresectable,malignant mesothelioma. The n...company learned that total events in the study had...lan for the study, the company must wait,until 316...
...urnal of the American Medical ... widely used to treat type 2,diabetes has been fou...ardial infarction) or stroke when used alone or in...cording to a Cleveland Clinic study. The study pu...e,American Medical Association reports that use of...
Other Medicine Technology:Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program 2Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program 3Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure 2Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure 3
(Date:11/30/2009)... , NEW YORK, Nov. 30 Report...port is available in its catalogue: ,, Key Pla...merging strategies in ingredients, pharma, food an...649/Key-Players-and-Innovative-Start-Ups-in-Nutrac...-food-and-drinks.html ,, Nutraceuticals are bi...
(Date:11/30/2009)..., WASHINGTON, Nov. 30 - Salon Leau...e" on Monday, December 7(th) to raise funds and cr...d terminal diseases. All proceeds from each haircu...n,s Research Hospital. ,, Salon Leau has been ...e salon is owned by LoAnn Lai, widely recognized f...
(Date:11/30/2009)... , NASHVILLE, Tenn., Nov. 30 /PRNewswire/ -...about gifts for the holidays. For a loved one with...mily members and friends oftentimes struggle with ...ving , one of the leading providers of senior livi...s and dementia care , offers these suggestions. ,...
(Date:11/30/2009)..., CHICAGO, Nov. 30 Physicians at...orted today on results of a study demonstrating th...angiography (cCTA) by Rcadia,s COR Analyzer System...tery stenosis in hospital emergency department (ED...tomated system to enhance the use of cCTA has pote...
(Date:11/30/2009)...ONovember 30, 2009A pet owner knows the enormous j...lly in troubled times. Most pets are considered im...mpanions. A growing body of research now documents...opment, elderly care, mental illness, physical imp...the rehabilitation of incarcerated youth and adult...
Breaking Medicine News(10 mins):Health News:Reportlinker Adds Key Players and Innovative Start-Ups in Nutraceuticals: Emerging Strategies in Ingredients, Pharma, Food and Drinks 2Health News:Reportlinker Adds Key Players and Innovative Start-Ups in Nutraceuticals: Emerging Strategies in Ingredients, Pharma, Food and Drinks 3Health News:Reportlinker Adds Key Players and Innovative Start-Ups in Nutraceuticals: Emerging Strategies in Ingredients, Pharma, Food and Drinks 4Health News:Reportlinker Adds Key Players and Innovative Start-Ups in Nutraceuticals: Emerging Strategies in Ingredients, Pharma, Food and Drinks 5Health News:Reportlinker Adds Key Players and Innovative Start-Ups in Nutraceuticals: Emerging Strategies in Ingredients, Pharma, Food and Drinks 6Health News:Georgetown Hair Salon Helps St. Jude Find A Cure 2Health News:Gift Ideas for Loved Ones with Alzheimer's/Dementia 2Health News:Rcadia COR Analyzer(R) System Demonstrates Potential in Emergency Department Triage of Chest Pain Patients at Low to Moderate Risk of Coronary Artery Disease 2Health News:Rcadia COR Analyzer(R) System Demonstrates Potential in Emergency Department Triage of Chest Pain Patients at Low to Moderate Risk of Coronary Artery Disease 3Health News:The therapeutic benefits of the human-animal bond 2
... have found that even a two-minute delay in severi...on //reserves and offset anemia for months. I...oor nations. It is a problem particularly in devel... be reversible, even with iron treatments. ...
... has urged the doctors working in various hospital...nti-rabies vaccine, as recommended by World Health...said that by following the intra-dermal route, the...sociation had taken the decision in view of increa...
... nearly 24% of all diseases in adults and 33% of d...O) said // that all this can be prevented by livin...ensively seen in developing countries and could be...tory infections, various forms of accidental injur...
...e afro American women should be first vaccinated a...s recently approved by the FDA //. This was publi...researchers at The Miriam Hospital and Brown Medic...an article in the January edition of the journal p...
...ween life and death, suffering an extremely rare c...res //a double kidney transplant, which will give ...tely have the perfect match, so they will be donat... for your children. But now things are looking ver...
...wealth to consider alloting specific funds for r...y under the jurisdiction of the state governments... conference, he said that , the measure was essent...h the proposal to federal Health Minister Tony Abb...
Other Medicine News:Health News:Infants have better iron reserves if umbilical cord clamping is delayed 2Health News:Infants have better iron reserves if umbilical cord clamping is delayed 3Health News:Afro American Women at a High Risk of HPV and Hence Should Be Vaccinated 2
McPherson Speculum
Storz Twisted Snare Wire
Thorton Fixation Ring 16 mm
McNeil-Goldman Scleral and Blepharostat Ring
Medicine Products: