Navigation Links
Viventia biotech reports synergystic effect of its Proxinium,antibody in combinaton with chemotherapy and radiation

- Results Reported at the American Association for Cancer Research (AACR) Annual Meeting -

TORONTO, April 18, 2007 /PRNewswire/ - Viventia Biotech Inc., a privately held biopharmaceutical company advancing a portfolio of novel antibody products focused on cancer, today announced results of in vitro cytotoxicity and in vivo pharmacokinetic studies conducted to evaluate the potential for combining its phase III anti-cancer antibody therapeutic, Proxinium(TM), with first-line standard of care therapy for squamous cell carcinoma of the head & neck (SCCHN). The data were presented at the Annual Meeting of the American Association for Cancer Research (AACR), which runs from April 14-18, 2007 in Los Angeles, California.

Viventia's lead product, Proxinium(TM), is being developed to treat late stage, locally advanced head and neck cancer and is currently enrolling patients in its TARGET trial, a pivotal Phase III global clinical trial that is expected to complete accrual by the end of 2007. Proxinium(TM) targets the cancer antigen EpCAM.

The combination of Proxinium(TM) with cisplatin, carboplatin, paclitaxel, 5-fluorouracil, and docetaxel resulted in a significant additive cytotoxic effect (p < 0.05) as compared to the chemotherapeutic agents administered alone. The sequence of drug administration did not influence the outcome. The combination of Proxinium(TM) with radiotherapy led to a synergistic cytotoxic effect when Proxinium(TM) was administered after radiotherapy or additive effects when Proxinium(TM) was administered before or at the same time as radiotherapy.

"The data from these studies clearly demonstrate the additive cytotoxic effect of Proxinium(TM) when used either in combination with chemotherapeutic agents or with radiation therapy," said Dr. Barry Wenig, Head of Otolaryngology - Head and Neck Cancer at Evanston Northwestern Healthcare Centre. "These data offer exciting possibili ties for the use of Proxinium(TM) not solely as a local immunotherapy, but more importantly as an adjunct to the current first-line therapies and even as a precursor to surgery."

Dr. Nick Glover, President and CEO of Viventia Biotech Inc. commented: "Our development strategy for Proxinium(TM) is to aggressively pursue initial approval for the treatment of late stage, palliative head and neck cancer, to be followed by a broad clinical program intended to support the addition of Proxinium(TM) to standard chemotherapy, radiotherapy and chemoradiotherapy regimens for earlier lines of treatment. These data presented at AACR clearly show the significant promise of adding Proxinium(TM) to other treatment modalities in head and neck cancer. Our goal is to establish Proxinium(TM) as a key component in the multidisciplinary treatment of this devastating disease."

In vitro cytotoxicity was evaluated pre-, concurrent and post-treatment with Proxinium(TM) in SCCHN cell lines CAL 27 and SCC-15. Cell growth inhibition, in combination with various chemotherapeutic agents (cisplatin, carboplatin, paclitaxel, 5-fluorouracil, docetaxel, bleomycin, and methotrexate) was assessed using an MTS assay. Growth inhibition, in combination with radiotherapy, was assessed using a clonogenic assay. In vivo pharmacokinetic profiles generated from drug administration to Sprague-Dawley rats indicated that the pharmacokinetics of cisplatin, paclitaxel, and 5-fluorouracil was not affected when administered in combination with Proxinium(TM). In summary, no antagonism was observed in in vitro or in vivo studies with Proxinium(TM) in combination with either chemo- or radiotherapy. The additive and synergistic cytotoxic effects demonstrated in this study indicate the potential utility of Proxinium(TM) in conjunction with more conventional treatment modalities for patients with SCCHN and suggest that Proxinium(TM) in conjunction with first line standard of care therapy may be of greater bene fit than standard care alone.

Viventia Biotech retains full global product rights to Proxinium(TM). The Company is seeking partners for Proxinium(TM) capable of complementing Viventia's development expertise with their global sales, marketing and commercial capabilities.

About Viventia Biotech:

Viventia Biotech Inc. is a biopharmaceutical company generating a pipeline of fully human antibodies and identifying novel targets for the treatment of cancer. Its lead products have been further developed into Armed Antibodies(TM); powerful and precise anti-cancer drugs that combine cytotoxic protein payloads with the highly precise tumor-targeting characteristics of monoclonal antibodies to overcome various forms of cancer. Viventia's lead product, Proxinium(TM), is undergoing a global Phase III clinical trial - TARGET - for the treatment of head and neck cancer. Viventia is also developing Vicinium(TM), which is in a Phase II clinical study for the treatment of bladder cancer, and VB6-845, beginning a Phase I/II clinical trial for the treatment of solid tumors. The Company has created a portfolio of follow-on fully human antibody drug candidates and has a discovery engine to provide a rich and sustainable long-term pipeline.

CONTACT: James Smith, Tel. (416) 815-0700 x 229, Fax. (416) 815-0080,Email: , www.viventia.com, www.proxinium.com jsmith@viventia.com

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


'"/>




Related medicine technology :

1. IR BioSciences Announces Data Demonstrating Radilex Stimulation of Stem Cells Results in Hematopoietic Recovery Following Lethal Irradiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... BASEL, Switzerland and SAN DIEGO ... Houston , Inc., a global leader in viral gene ... gene therapy treatments for congestive heart failure and other ... to develop a scalable manufacturing process and produce cGMP-grade ... clinical trials. --> ...
(Date:2/10/2016)... NEW YORK , Feb. 10, 2016 ... clinical-stage biopharmaceutical company, announced today that it has filed ... Myeloid Leukemia and other cancers. --> ... of treating cancer by administration of Ceplene (histamine dihydrochloride) ... also provides methods of predicting the efficacy of Ceplene ...
(Date:2/10/2016)... , Feb. 10, 2016  Oxis International Inc. ... drug, OXS-1550, was described as a "clinical trial triumph" ... drug went into complete cancer remission. ... of Minnesota Masonic Cancer Center. --> ... of Minnesota Masonic Cancer Center. --> ...
Breaking Medicine Technology:
(Date:2/10/2016)... Tucson, AZ (PRWEB) , ... February 10, 2016 , ... ... prompted the Aging Life Care Association™ (ALCA) to conduct a survey that takes a ... aging experts released today illustrates the prevalence and causes of TBI among the aging ...
(Date:2/10/2016)... ... 10, 2016 , ... United Benefit Advisors (UBA), the nation’s ... to its growing list of Partner Firms. S.S. Nesbitt is headquartered in ... Huntsville and in between. , Harnessing the experience and insights of the agency’s ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... AxoGen, Inc. ... will report results for the fourth quarter and full year ended December 31, 2015 ... a conference call and webcast for the investment community following the release at 4:30 ...
(Date:2/10/2016)... ... February 10, 2016 , ... AHRA: The Association for ... speaker Jan Fox will serve as keynote speaker at the organization’s 2016 Spring ... tools to more effectively communicate with their own organizational staff and leadership. ...
(Date:2/10/2016)... AZ (PRWEB) , ... February 10, 2016 , ... For ... in new book , Pioneering book "Better with Age: The Ultimate Guide to Brain ... neuroplasticity can improve memory. The book’s publication date is March 16, 2016. ...
Breaking Medicine News(10 mins):