Navigation Links
Vision Deficit in Retinitis Pigmentosa Mice Corrected with DNA,Nanoparticles

CLEVELAND--(BUSINESS WIRE)--Jun 4, 2007 - Copernicus Therapeutics, Inc. announced today that a research team at University of Oklahoma Health Sciences Center, led by Dr. Muna Naash, Professor of Cell Biology, demonstrated that Copernicus' DNA nanoparticles corrected vision defects in a mouse model of retinitis pigmentosa (RP). These findings were presented at the American Society of Gene Therapy meeting in Seattle, WA. Mutations in genes important in the biology of vision cause RP, a common genetic form of visual impairment affecting nearly 70,000 patients in the United States.

"These exciting results demonstrate that delivery of normal copies of genes into photoreceptor cells can correct vision defects in RP," said Mark Cooper, M.D., Senior Vice President of Science and Medical Affairs. "In addition to the promise of providing corrective therapy for genetic diseases such as retinitis pigmentosa, nucleic acid nanoparticles may also offer the potential to provide effective treatments for more complex disorders such as diabetic retinopathy, macular degeneration, and various diseases that injure ganglion cells and the optic nerve."

"We are pleased by the promise of these results and look forward to moving these studies forward to a potential human clinical trial," said Dr. Naash.

"Gene therapy holds great potential for treating and possibly curing a variety of vision-robbing retinal degenerative diseases," says Stephen Rose, Ph.D., Chief Research Officer, Foundation Fighting Blindness. "Dr. Naash and Copernicus are demonstrating that nanoparticles show excellent potential for safely and effectively delivering therapeutic genes to the retina." Dr. Naash's work was funded in part by the Foundation Fighting Blindness.

About Copernicus, the University of Oklahoma and the Foundation Fighting Blindness

Copernicus Therapeutics, Inc., a privately held biotechnology company, is dedicated to deli vering the promise of nucleic acid therapeutics. The same technology that is being tested for its ability to deliver corrective nucleic acids for various blinding disorders is being developed for introducing the cystic fibrosis gene to the lungs of CF patients. The Copernicus multi-component delivery platform can be used to develop nucleic acid therapies for numerous human diseases. Additional information about Copernicus is available at www.cgsys.com.

The University of Oklahoma is a doctoral degree-granting research university serving the educational, cultural, economic and health care needs of the state, region and nation. The OU Health Sciences Center, which is located in Oklahoma City, is one of only four comprehensive academic health centers in the nation with seven professional colleges. Additional information about University of Oklahoma Health Sciences Center is available at www.ouhsc.edu.

The urgent mission of the Foundation Fighting Blindness is to drive the research that will provide preventions, treatments and cures for people affected by retinitis pigmentosa (RP), macular degeneration, Usher syndrome, and the entire spectrum of retinal degenerative diseases. Visit www.FightBlindness.org for more information on the Foundation's efforts.

Contact

Copernicus Therapeutics, Inc.
Robert C. Moen, M.D., Ph.D., 216-231-0227 x26
President & CEO
or
Mark J. Cooper, M.D., 216-231-0227 x23
Sr. V.P. of Science and Medical Affairs
OR
University of Oklahoma
Catherine F. Bishop, 405-325-1543
Vice President Public Affairs
OR
Foundation Fighting Blindness
David Harrison, 410-804-1728
Media Contact


'"/>




Related medicine technology :

1. OXiGENE Announces a Poster Presentation Highlighting Results from its Study of ZYBRETSTAT CA4P in Myopic Macular Degeneration (Study MMD-213) at the 47th Annual Meeting of the Association of Research in Vision and Ophthalmology
2. Isotechnikas Lead Drug, ISA247, To Be Highlighted at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
3. Inspire Announces Presentations at 2007 Association for Research in Vision and Ophthalmology Annual Meeting
4. Sirion Therapeutics Announces Clinical Data to be Presented at the 2007 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
5. Advanced Cell Technologys Ability to Rescue Vision in Blind Rats Noted in Scientific American
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... CHICAGO, Ill. , March 23, 2017 ... dancer and Emmy Award-winning choreographer Julianne Hough ... campaign called "Get in the Know about ME in ... is dedicated to inspiring women to learn about and ... 10 women, 1 and to address their symptoms ...
(Date:3/23/2017)... 2017 The global dermatology devices ... billion by 2025, according to a new report by Grand ... a faster rate due to rising concern amongst people regarding ... of esthetic procedures used for treating hair - and skin-related ... considered as the highest revenue generators for the market. ...
(Date:3/22/2017)... , March 23, 2017 ReportsnReports.com ... a latest research report. The global vagus nerve stimulation ... of surgeons focus toward minimally invasive VNS procedures. Few ... to few developed countries having high standards of healthcare ... ...
Breaking Medicine Technology:
(Date:3/23/2017)... ... March 23, 2017 , ... It’s that time of year again! Time ... about summer internships , which can be frustrating when they don’t even know ... Media Group, a boutique public relations firm outside of Philadelphia, have offered these three ...
(Date:3/23/2017)... ... March 23, 2017 , ... The founders of Dr. ... as winners of American Dreams & Good Housekeeping Seal Initiative, a nationwide search ... and Good Housekeeping. , Steven Wang, MD ., a renowned dermatologist and ...
(Date:3/23/2017)... ... March 23, 2017 , ... News Advisory/Interview Opportunity , ... helped score a major victory in Europe for public health and the environment and ... Based on rigorous scientific research and the overwhelming support of European citizens, the European ...
(Date:3/23/2017)... ... March 23, 2017 , ... “A Respectful Response To ... Response To Atheist Manifesto” is the creation of published author Richard Hostetter, a ... sixty years. He holds graduate degrees from Kent State University and the University ...
(Date:3/22/2017)... ... March 22, 2017 , ... Cosmetic Town, an ... issue of its companion print magazine. The new magazine, scheduled for release in ... information provided by board-certified doctors from across the country. , According to the ...
Breaking Medicine News(10 mins):