Navigation Links
Vision Deficit in Retinitis Pigmentosa Mice Corrected with DNA,Nanoparticles

CLEVELAND--(BUSINESS WIRE)--Jun 4, 2007 - Copernicus Therapeutics, Inc. announced today that a research team at University of Oklahoma Health Sciences Center, led by Dr. Muna Naash, Professor of Cell Biology, demonstrated that Copernicus' DNA nanoparticles corrected vision defects in a mouse model of retinitis pigmentosa (RP). These findings were presented at the American Society of Gene Therapy meeting in Seattle, WA. Mutations in genes important in the biology of vision cause RP, a common genetic form of visual impairment affecting nearly 70,000 patients in the United States.

"These exciting results demonstrate that delivery of normal copies of genes into photoreceptor cells can correct vision defects in RP," said Mark Cooper, M.D., Senior Vice President of Science and Medical Affairs. "In addition to the promise of providing corrective therapy for genetic diseases such as retinitis pigmentosa, nucleic acid nanoparticles may also offer the potential to provide effective treatments for more complex disorders such as diabetic retinopathy, macular degeneration, and various diseases that injure ganglion cells and the optic nerve."

"We are pleased by the promise of these results and look forward to moving these studies forward to a potential human clinical trial," said Dr. Naash.

"Gene therapy holds great potential for treating and possibly curing a variety of vision-robbing retinal degenerative diseases," says Stephen Rose, Ph.D., Chief Research Officer, Foundation Fighting Blindness. "Dr. Naash and Copernicus are demonstrating that nanoparticles show excellent potential for safely and effectively delivering therapeutic genes to the retina." Dr. Naash's work was funded in part by the Foundation Fighting Blindness.

About Copernicus, the University of Oklahoma and the Foundation Fighting Blindness

Copernicus Therapeutics, Inc., a privately held biotechnology company, is dedicated to deli vering the promise of nucleic acid therapeutics. The same technology that is being tested for its ability to deliver corrective nucleic acids for various blinding disorders is being developed for introducing the cystic fibrosis gene to the lungs of CF patients. The Copernicus multi-component delivery platform can be used to develop nucleic acid therapies for numerous human diseases. Additional information about Copernicus is available at www.cgsys.com.

The University of Oklahoma is a doctoral degree-granting research university serving the educational, cultural, economic and health care needs of the state, region and nation. The OU Health Sciences Center, which is located in Oklahoma City, is one of only four comprehensive academic health centers in the nation with seven professional colleges. Additional information about University of Oklahoma Health Sciences Center is available at www.ouhsc.edu.

The urgent mission of the Foundation Fighting Blindness is to drive the research that will provide preventions, treatments and cures for people affected by retinitis pigmentosa (RP), macular degeneration, Usher syndrome, and the entire spectrum of retinal degenerative diseases. Visit www.FightBlindness.org for more information on the Foundation's efforts.

Contact

Copernicus Therapeutics, Inc.
Robert C. Moen, M.D., Ph.D., 216-231-0227 x26
President & CEO
or
Mark J. Cooper, M.D., 216-231-0227 x23
Sr. V.P. of Science and Medical Affairs
OR
University of Oklahoma
Catherine F. Bishop, 405-325-1543
Vice President Public Affairs
OR
Foundation Fighting Blindness
David Harrison, 410-804-1728
Media Contact


'"/>




Related medicine technology :

1. OXiGENE Announces a Poster Presentation Highlighting Results from its Study of ZYBRETSTAT CA4P in Myopic Macular Degeneration (Study MMD-213) at the 47th Annual Meeting of the Association of Research in Vision and Ophthalmology
2. Isotechnikas Lead Drug, ISA247, To Be Highlighted at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
3. Inspire Announces Presentations at 2007 Association for Research in Vision and Ophthalmology Annual Meeting
4. Sirion Therapeutics Announces Clinical Data to be Presented at the 2007 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
5. Advanced Cell Technologys Ability to Rescue Vision in Blind Rats Noted in Scientific American
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... Idaho , Jan. 12, 2017  Albertsons ... by Accreditation Commission for Health Care (ACHC) for ... largest national food and drug chain with this ... for pharmacy patients. Accreditation by ACHC ... national standards to facilitate a higher level of ...
(Date:1/13/2017)... Jan. 13, 2017  Biologics Prescribers Collaborative ... Administration (FDA) for issuing final guidance calling ... This policy is an important win for ... essential for pharmacovigilance, patient safety and transparency. ... voiced to FDA, we remain concerned with "random" suffixes ...
(Date:1/12/2017)... COTTAGE, New York , January 12, 2017 ... to observe steady growth in 2016, reaching beyond US$ 3.8 Bn ... diagnosis, and treatment is anticipated to fuel the demand for PIVC. ... market growth. North America is likely to ... expected to emerge at the fastest rate. ...
Breaking Medicine Technology:
(Date:1/15/2017)... ... January 15, 2017 , ... Accreditation Commission for Health ... its specialty care services. Albertsons Companies is the largest national food and ... pharmacy patients. , Accreditation by ACHC reflects Albertsons Companies’ dedication and commitment to ...
(Date:1/15/2017)... ... 14, 2017 , ... Wondering where to go this Valentine's Day? Well, there ... for a romantic, lobster feast in the comfort of your own home. Lobster Gram ... dinners will be featured until February 15th, 2017. , Romantic Dinner one is ...
(Date:1/14/2017)... ... January 14, 2017 , ... Healthy living brand ... of activated charcoal products. With more and more people opting to go organic ... to how they cater to specific needs. , Moody Zook focused particularly on ...
(Date:1/14/2017)... California (PRWEB) , ... January 14, 2017 , ... "TransFreeze Volume 3 is a self ... freeze mask effect in Final Cut Pro X," said Christina Austin - CEO of Pixel ... create a unique freeze frame transition from one clip to the next. , ...
(Date:1/13/2017)... ... January 13, 2017 , ... A January 10 article in ... according to the publication, with an emphasis on some new techniques that the publication ... who is known more casually to his patients and colleagues as Dr. J, comments ...
Breaking Medicine News(10 mins):