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Viral Enzyme Recruited in Fight Against Ear Infection

t lysin can eliminate these bacteria from the ear using mice developed at St. Jude that represented the first such model in which acute otitis media develops in a similar way that it develops the disease in children. The mice were treated by purified lysin that was prepared in the laboratory of Vincent A. Fischetti, Ph.D., a professor and co- head of the Laboratory of Bacterial Pathogenesis and Immunology at The Rockefeller University. He was assisted by Jutta M. Loeffler, postdoctoral associate. Fischetti is senior author of the "PLoS" paper.

"The nasal spray may eventually be used weekly during flu season to keep a person free of Streptococcus pneumoniae or after infection with the flu virus," said Fischetti. "This might truly be a case in which an ounce of prevention would be worth a pound of cure."

Other St. Jude authors of this paper include Asa Karlstrom and Amy R. Iverson (St. Jude).

This work was supported in part by the United States Public Health Service and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit www.stjude.org.

CONTACT: Carrie Strehlau, St. Jude Public Relations, +1-901-495-2295,; Summer Freeman, St. Jude Public Relations,+1-901-495-3061, , or Marc Kusinitz, Ph.D.,Scientific Communications, +1-901-495-5020, carrie.strehlau@stjude.org '"/>




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