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Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual,Meeting of the American Association of Cancer Research (AACR)

NEW HAVEN, Conn., April 13, 2007 /PRNewswire-FirstCall/ -- VION PHARMACEUTICALS, INC. announced today that data on its lead anticancer agent Cloretazine(R) (VNP40101M) will be presented in posters at the 100th Annual Meeting of the American Association of Cancer Research in Los Angeles, California. All three posters will be available on Vion's website, www.vionpharm.com on the day of presentation.

All posters will be presented in the Los Angeles Convention Center Exhibit Hall at the times and locations listed below:

Poster #16 (section 31), entitled "Effects of Cloretazine(R) on multidrug resistant cell lines" will be presented on Sunday, April 15 from 1 to 5 p.m. These studies were designed to determine whether Cloretazine(R) has the potential to circumvent one of the most common mechanisms of resistance to cancer chemotherapy agents.

Poster # 5 (section 5) entitled "Low levels of pre-treatment O6 - alkylguanine transferase (AGT) in patients with AML correlate with response to Cloretazine(R) (VNP40101M) induction therapy" will be presented on Monday, April 16 from 1 to 5 p.m. Since overexpression of AGT has been associated with drug resistance preclinically, these data were collected as part of a Phase II clinical trial of Cloretazine(R) to assess whether pretreatment AGT levels could be correlated with response.

Poster #14 (section 27) entitled "Sequence dependent cytotoxocity of Cloretazine(R) in combination with anthracyclines" will be presented on Tuesday, April 17 from 1 to 5 p.m. These preliminary in vitro studies were designed to assess the effects of various sequences of administration of Cloretazine(R) and anthracyclines on cell survival and provide direction as to which combinations to further evaluate in preclinical models.

In addition to Vion's Cloretazine(R) (VNP40101M) posters, two posters will be presente
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