Navigation Links
Vion Pharmaceuticals Presents Clinical Data from a Phase II Trial,of Cloretazine (VNP40101M) in Elderly AML Patients with Unfavorable,Cytogenetics at EHA Meeting

NEW HAVEN, Conn., June 11, 2007 /PRNewswire-FirstCall/ -- Vion Pharmaceuticals, Inc. announced that it presented clinical data in a poster session at the 12th Congress of the European Hematology Association (EHA) Meeting in Vienna, Austria on its lead anticancer agent Cloretazine(R) (VNP40101M) as a single agent in a multi-center international Phase II clinical trial in a subset of elderly patients with acute myelogenous leukemia (AML) or high-risk myelodysplastic syndrome (MDS) and unfavorable cytogenetics.

The Phase II trial was conducted from March 2004 to May 2006. The study treated 129 patients of 60 years of age or older with previously untreated AML or high-risk MDS. Previously data were presented on 104 patients (Giles et al, Journal of Clinical Oncology, January 1, 2007). Treatment consisted of Cloretazine(R) (VNP40101M) in a 600 mg/m2 dose administered in a 30-60 minute infusion on day 1 (second induction allowed) and provided the option for an additional 400 mg/m2 as consolidation for responders (complete remission (CR) or complete remission with incomplete platelet count (CRp). The primary endpoint was overall response (CR and CRp). Overall survival and relapse-free survival were also analyzed.

Data were presented at the EHA Meeting in a subset of 59 patients with unfavorable cytogenetics. Of these patients, 28 (47%) had secondary AML, 21 (36%) had de novo AML, and 10 (17%) had high-risk MDS. Overall, the response rate in patients with unfavorable cytogenetics was 25%. Response by diagnosis was: de novo AML (48%); MDS (30%) and secondary AML (7%). Twelve (20%) patients died within 30 days of receiving induction treatment. The majority of early death was in patients with secondary AML and was due to disease progression.

Dr. Norbert Vey, head of the Leukemia Program, Department of Hematology, at the Institut Paoli-Calmettes in Marseille, France, commented, "Patients with unfavorab
'"/>




Page: 1 2 3 4

Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
4. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
5. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
6. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
7. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
8. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
9. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
10. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
11. Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
Post Your Comments:
(Date:5/16/2013)... , May 16, 2013  HeartWare International, Inc. (NASDAQ: ... of less invasive, miniaturized circulatory support technologies that are revolutionizing ... Doug Godshall is scheduled to present ... EDT on Monday, May 20, 2013.  The conference is being ... A live webcast of the Company,s presentation at ...
(Date:5/16/2013)... May 16, 2013  Amgen (NASDAQ: AMGN ) ... Tuesday, May 21, 2013, at the Sheraton New York Times ... at 10:00 a.m. Eastern Daylight Time. Joseph P. ... and Development at Amgen, will present at the conference. Live ... Calendar on Amgen,s website, www.amgen.com , under Investors. A ...
(Date:5/16/2013)... May 16, 2013 OrthoView PSL ... U.S. to access the widely-used OrthoView digital templating software ... Internet connection to get started. OrthoView, the ... over 10 years, is dedicated to enabling orthopaedic surgeons ... x-ray images, when printed film is unavailable. Over 5,000 ...
Breaking Medicine Technology:HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2OrthoView Announces the U.S. Launch of a New, Subscription-based, Digital Planning and Templating Solution for Individual Orthopaedic Surgeons 2
... ,, LONDON , June 16 Market Publishers Ltd ... are available in its catalogue. , ... The UK Medical Devices Industry: Increasing Incidence of ... analysis on the medical devices industry in the UK. Key markets covered ...
... Phytomedics Inc., a clinical stage biopharmaceutical company developing a novel ... announced that Dr. Laurie Smaldone , MD, President and Chief Executive ... Summit, on June 17th, 2010 , held at New York ... , , , ...
Cached Medicine Technology:Healthcare Equipment & Services Research June Updates by MarketPublishers.com 2Healthcare Equipment & Services Research June Updates by MarketPublishers.com 3Healthcare Equipment & Services Research June Updates by MarketPublishers.com 4Phytomedics Inc. to Present at 2010 New York Venture Summit 2
(Date:5/19/2013)... People in Minnesota have a great option to ... its 28 Day Fat Loss Formula. The best part ... their own home. The product sells for $135 dollars and ... accessed here: http://altmanfitness.com/28-day-fat-loss-formula/ , “Bikini season is almost ... but after using the 28 Day Fat Loss Formula they ...
(Date:5/19/2013)... The muscles in the human body ... one of the biggest and most significant nervous systems ... peripheral system comprises of peripheral nerves that reside outside ... ensure that the limbs and hands, as well as ... get damaged due to trauma or physical injury, their ...
(Date:5/19/2013)... According to a new market research report ... 2018): By Applications (Healthcare (Endoscopy, Radiology, Ophthalmology), Surveillance, ... IS, Infrared, X-Ray) And Geography" published by MarketsandMarkets, ... billion in 2012 and is expected to reach ... of 3.84% from 2013 to 2018. In terms ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 The report ... Global Trends & Forecasts up to 2017” published by ... market with analysis and forecasting of the global volume ... identifies the driving and restraining factors for the global ... imperatives, and challenges. The market is segmented and revenue ...
(Date:5/19/2013)... 19, 2013 Americans live closer to ... newest American Veterinary Medical Association (AVMA) U.S. Pet Ownership ... owners consider their dog a member of the family, ... as much five years earlier. , According to the ... the national income dedicated to pets has increased every ...
Breaking Medicine News(10 mins):Health News:Ultimate Neuropathy Support System Launched by Neuracel - Reaching New Heights in Herbal Medication for Peripheral Neuropathy 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 3Health News:Feed Additives Market to Reach $19.5 Billion by 2017 at a CAGR of 3.8% - New Report by MarketandMarkets 2Health News:Feed Additives Market to Reach $19.5 Billion by 2017 at a CAGR of 3.8% - New Report by MarketandMarkets 3Health News:Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing 2Health News:Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing 3
... to lead BCBSIL,s sales and,marketing, CHICAGO, May ... senior vice president, Local and Consumer Markets, for,Blue ... his new role, Freer,will oversee small, mid-market, and ... as well as manage HMO Illinois. Freer also,will ...
... teach low-income adults about healthy food choices is a ... benefits achieved, reports a cost-effectiveness study in the May/June ... http://www.jneb.org/ ). , Led by Jamie Dollahite, Ph.D., R.D., ... evaluations to assess the costs versus benefits of the ...
... 13 Medivation, Inc.,(Nasdaq: MDVN ) today announced that David ... conferences., -- Rodman & Renshaw 5th Annual Global Healthcare ... p.m. local time at Le Meridien Beach Plaza Hotel in ... Generic Pharmaceuticals Conference on Wednesday, May 28 ...
... May 13 /Xinhua-PRNewswire-FirstCall/ -- China Sky One,Medical, Inc. ... of pharmaceutical, medicinal and diagnostic products in China,today ... at 5:00 p.m. Eastern,Time on May 15, 2008 ... Joining Mr. Yan-qing Liu, Chairman, CEO and ...
... The Quantum Group,(Amex: QGP ) today announced ... has expanded its relationship with one of its ... of its Community Health,System. This expanded relationship will ... Medicaid patients. The contract will initially cover,South Florida, ...
... Fla., May 13 A complete review of ... a multi-disciplinary and,collaborative approach to weight loss, according ... The use of several proven,weight management strategies in ... the greatest likelihood of success., NBC,s hit ...
Cached Medicine News:Health News:Blue Cross and Blue Shield of Illinois Names New Vice President, Local and Consumer Markets 2Health News:Expanded food and nutrition program shows $10 benefit for each $1 spent 2Health News:Medivation Announces Participation in Upcoming Conferences 2Health News:China Sky One Medical, Inc. Announces Conference Call to Discuss First Quarter 2008 Results 2Health News:The Quantum Group Executes First Medicaid Service Contract with HMO 2Health News:The Quantum Group Executes First Medicaid Service Contract with HMO 3Health News:Research Converging in Favor of New Approach to U.S. Weight Problem 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: