( al results todiffer materially from th...)Vical's Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA,Vaccine Performance; Yields Antibody Responses Comparable to,Electroporation Without Tolerability Issues,Health

al results to differ materially from those projected, including: whether Vical or others will continue development of DNA vaccines; whether Vaxfectin(TM) formulation, needle-free delivery or electroporation will sufficiently enhance immunogenicity of DNA vaccines; whether initial human testing of a Vaxfectin(TM)-formulated DNA vaccine for pandemic influenza will begin as planned, if at all; whether safety and tolerability demonstrated in animal studies will correlate to results in humans; whether additional enhancement options may become available, and if so, whether they will be used in future applications; whether any product candidates will be shown to be safe and effective in clinical trials; the timing, nature and cost of clinical trials; whether Vical or others will seek or gain approval to market any product candidates; whether Vical or others will succeed in marketing any product candidates; and additional risks set forth in the company's filings with the Securities and Exchange Commission. These forward-looking statements represent the company's judgment as of the date of this release. The company disclaims, however, any intent or obligation to update these forward-looking statements.

    Contacts:  Investors:                     Media:

               Alan R. Engbring               Susan Neath

               Vical Incorporated             Porter Novelli Life Sciences

               (858) 646-1127                 (619) 849-6007

               Website: www.vical.com

CONTACT: Investors, Alan R. Engbring of Vical Incorporated,+1-858-646-1127; or Media, Susan Neath of Porter Novelli Life Sciences,+1-619-849-6007, for Vical Incorporated

Web site: http://www.vical.com/

Ticker Symbol: (NASDAQ-NMS:VICL)

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