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Vical Interim Clinical Results Demonstrate Safety and Tolerability,of Inovio Biomedical's Electroporation DNA Delivery Technology

were localized to the treatment site, with the most frequent being mild injection site pain.

Objective tumor responses, defined as 50% tumor shrinkage or complete disappearance, were observed in 12 of 39 (31%) of the lesions that were targeted for observation. Of these observed lesions, seven of 18 treated tumors (38%) and five of 21 untreated tumors (24%) showed objective responses. The response of untreated tumor lesions suggests the possibility of a systemic effect of the treatment. Two subjects showed activity in untreated tumors distant from the site of administration of the therapy, including one subject showing shrinkage and disappearance of lung tumors.

"This is the third set of interim clinical data to be released this year supporting the safety and tolerability of Inovio's electroporation technology for delivering DNA immunotherapeutics in humans. The objective tumor responses observed by Vical add to a body of data suggesting that electroporation of plasmid-based immunotherapeutics can induce immune and anti-tumor responses," said Dr. Avtar Dhillon, Inovio's President and CEO. "We look forward to advancing the business opportunities that become more apparent with such results."

About Inovio's Immunotherapy Products

DNA-based immunotherapy products have the potential to by-pass inherent scientific obstacles of conventional vaccines that prevent their development for cancer and chronic infectious diseases such as HIV and hepatitis C. Pre-clinical data has indicated the potential ability of Inovio's technologies to safely and effectively deliver and significantly enhance the potency of such immunotherapies.

Inovio's DNA-based immunotherapy products consist of DNA plasmids and the Elgen and MedPulser DNA delivery systems. DNA plasmids are designed to express antigens that can induce an immune response specific to a cancer or infectious disease-causing organism. These plasmids are created synthetically and readily manufacture
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