( / II Trial of VELCADE and Perifosine (...)Velcade (bortezomib) for Injection Survival Data in Front-Line,Multiple Myeloma Patients to be Featured at 11th International,Myeloma Workshop,Health

/ II Trial of VELCADE and Perifosine (KRX-0401) in Relapsed / Refractory Multiple Myeloma Patients Previously Treated with VELCADE: Preliminary Results * Lead investigator: Paul Richardson, M.D., Dana-Farber Cancer Institute * Abstract #608; Poster session: Thursday 28th June, 4:30 p.m. -- Combination of the mTOR-Inhibitor Rapamycin and Proteasome Inhibitor VELCADE is Synergistic In Vitro in Multiple Myeloma * Lead investigator: Xavier Leleu, M.D., Centre Hospitalier Regional Universitaire de Lille * Abstract #534; Poster session: Tuesday 26th June, 4:30 p.m.

About Multiple Myeloma (MM)

Multiple myeloma is the second most common hematologic malignancy and although the disease is predominantly a cancer of the elderly (the average age of onset is 65 to 70 years of age), recent statistics indicate both increasing incidence and younger age of onset. In the U.S., more than 50,000 individuals have MM and close to 20,000 new cases are diagnosed each year. Worldwide there are approximately 74,000 new cases and more than 45,000 deaths annually.

About VELCADE

VELCADE is being co-developed by Millennium Pharmaceuticals, Inc. and Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Millennium is responsible for commercialization of VELCADE in the U.S.; Janssen-Cilag is responsible for commercialization in Europe and the rest of the world. Janssen Pharmaceutical K.K. is responsible for commercialization in Japan. For a limited period of time, Millennium and Ortho Biotech Inc. will co-promote VELCADE in the U.S. VELCADE is approved in more than 80 countries worldwide.

In the U.S., VELCADE is indicated for the treatment of patients with multiple myeloma who have received at least one prior therapy. VELCADE is indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior therapy. VELCADE is c
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