M.D., The University of Tokushima Graduate School of Health Biosciences * Abstract #311; Poster session: Tuesday 26th June, 4:30 p.m. -- Effect of VELCADE Monotherapy and VELCADE Based Regimens on Bone Metabolism in Patients with Relapsed / Refractory Multiple Myeloma * Lead investigator: Evangelos Terpos, M.D., General Airforce Hospital * Abstract #320; Poster session: Tuesday 26th June, 4:30 p.m. -- Cystatin-C: An Early Marker of Renal Impairment and an Independent Predictive Factor for Survival in Multiple Myeloma. Reduction Post VELCADE Therapy * Lead investigator: Evangelos Terpos, M.D., General Airforce Hospital * Abstract #227; Poster session: Tuesday 26th June, 4:30 p.m. -- VELCADE in Renally Impaired Multiple Myeloma Patients * Lead investigator: Jesus San Miguel, M.D., PhD., Hospital Universitario de Salamanca * Abstract #1114; Poster session: Thursday 28th June, 4:30 p.m.

VELCADE Shows Potential in Additional Diseases and in Combination with Emerging Agents

New data will highlight VELCADE efficacy in amyloidosis, a disease of high unmet need, and in combination with new agents such as HSP90-, AKT- and mTOR-inhibitors. Abstract highlights include:

    -- Treatment of Light Chain (AL) Amyloidosis with the Combination of

       VELCADE and Dexamethasone

         * Lead investigator: Efstathios Kastritis, M.D., Alexandra Hospital,

           University of Athens School of Medicine

         * Abstract #913; Poster session: Thursday 28th June, 4:30 p.m.

    -- VELCADE and Tanespimycin in Multiple Myeloma: Pharmacology, Safety and

       Activity in Relapsed / Refractory Patients

         * Lead investigator: Paul Richardson, M.D., Dana-Farber Cancer

           Institute

         * Abstract #610; Poster session: Thursday 28th June, 4:30 p.m.

    -- A Multicenter Phase I
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