( the EBMT criteria. Results werepresent...)Velcade (bortezomib) for Injection Based Therapies Achieved,Survival Rates as High as 100 Percent in Newly Diagnosed Multiple,Myeloma Patients,Health

the EBMT criteria. Results were presented by Andrzej Jakubowiak, M.D., Ph.D., University of Michigan Comprehensive Cancer Center, and demonstrated a CR rate of 43 percent prior to SCT, which improved to 65 percent following SCT. At 16 months, 100 percent of patients were alive. Side effects were predictable and manageable, similar to those seen in previous VELCADE clinical trials.

Phase I / II Study of Upfront VELCADE, Lenalidomide and Dexamethasone in Multiple Myeloma: Early Results (Abstract #PO-715)

This Phase I / II study of VRD combination therapy was designed to determine the maximum tolerated dose (MTD) and efficacy in untreated MM patients. The preliminary analysis included 15 evaluable patients, who received VELCADE at 1.0 mg/m(2) or 1.3 mg/m(2) on days 1, 4, 8 and 11 of a 21- day schedule. Patients also received lenalidomide at 15, 20 or 25 mg on days 1 through 14 and dexamethasone at 40 mg corresponding with the VELCADE schedule. Patients were treated for up to eight cycles at four planned dose levels. MTD has not yet been reached. Response was assessed by modified EBMT criteria. Results were presented by Paul Richardson, M.D., Dana-Farber Cancer Institute, and showed an ORR (CR + partial response + minor response) of 100 percent, including a CR rate of 20 percent. Side effects were manageable and included hypophosphatemia, infections and thrombocytopenia. No grade 3 or higher peripheral neuropathy was observed.

About Multiple Myeloma

Multiple myeloma is the second most common hematologic malignancy and although the disease is predominantly a cancer of the elderly (the average age of onset is 65 to 70 years of age), recent statistics indicate both increasing incidence and younger age of onset. In the U.S., more than 50,000 individuals have MM and 20,000 new cases are diagnosed each year. Worldwide there are approximately 74,000 new cases and over 45,000 deaths annually.

About VELCADE

VELCADE is being co-developed
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