( ponse rate (ORR) of 100 percent includ...)Velcade (bortezomib) for Injection Based Therapies Achieved,Survival Rates as High as 100 Percent in Newly Diagnosed Multiple,Myeloma Patients,Health

ponse rate (ORR) of 100 percent, including a CR(1) rate of 20 percent.
"These spectacular results underscore the crucial role of VELCADE in front-line multiple myeloma," said Sagar Lonial, M.D., Emory University. "VELCADE has consistently delivered survival rates that are among the highest seen to date in this disease setting. These high survival rates were driven by the substantial complete remission rates seen when VELCADE has been added to multiple therapies. Oncologists generally use the most efficacious agents as front-line treatment to maximize outcomes for patients, and as such, VELCADE will be a leading therapy in this disease setting."

Frontline VMP in Elderly Multiple Myeloma Patients: Extended Follow-Up (Abstract #PO-718)

"The addition of VELCADE has produced the best complete remisssion and three-year survival rates ever reported with a melphalan prednisone therapy, providing results that are as powerful as stem cell transplantation without the associated side effects, recovery time and expense," said Maria-Victoria Mateos, M.D., Ph.D., Grupo Espanol de Multiple Myeloma. "With VELCADE added to this combination, we now are able to offer all patients, including those who historically could not have a transplant, an alternative that provides complete remission and prolongs lives."

The Phase I / II study evaluated efficacy and safety of VMP combination therapy in untreated MM patients aged 65 years or older with a median age of 75 years. The study included 54 evaluable patients ineligible for SCT. Patients received VELCADE at 1.0 mg/m(2) or 1.3 mg/m(2) on days 1, 4, 8, 11, 22, 25, 29 and 32 for four six-week cycles, then on days 1, 8, 15 and 22 for five five-week cycles. Patients also received melphalan at 9 mg/m(2) and prednisone at 60 mg/m(2) on days 1 through 4 of each cycle. Response was assessed using the European Group for Blood and Marrow Transplant (EBMT) criteria. Results were presented by Dr. Mateos and showed a
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