Navigation Links
Vaxiion Researchers Discover Novel Vaccine Delivery System in,Collaboration with San Diego State University

SAN DIEGO--(BUSINESS WIRE)--Mar 8, 2007 - Vaxiion Therapeutics, Inc. today announced that its researchers, in collaboration with San Diego State University, have discovered a 'minicell' vaccine delivery system that has potential to protect against several disease-causing infections.

These findings were published in an advance online edition of the journal, Vaccine, and the paper was published today, in the March 8th issue.

While most vaccines contain live micro-organisms, the 'minicell' vaccine studied mimics the live pathogen response without any risk of infection, making it particularly useful for immunizing children, the elderly and those with compromised immune systems. Additionally, the minicell vaccine is able to counter many infectious diseases in a cost-effective and efficient manner, and could solve serious infectious disease problems in developing countries.

"We have found a vaccine delivery method that has an advantage over other non-living vaccines in that the minicells stimulate all elements of the immune system that are required to protect people against infectious diseases," said Kathleen McGuire, SDSU biology professor and co-author of the paper.

In the study, the SDSU team created a vaccine against the lymphocytic choriomeningitis virus (LCMV), which causes a lethal form of meningitis in mice. The minicell vaccine protected 89 percent of immunized mice from death.

"Through this research, we've been able to create a platform technology that we hope will translate into many vaccine formulations," said Vaxiion's Matt Giacalone, study co-author and a 2006 graduate of SDSU's joint MBA/Ph.D. program.

Research funding was primarily provided by Vaxiion, a biotechnology company founded by SDSU biology professor Roger Sabbadini. He also served as co-author on the study.

"Based on the success of this translational work, Vaxiion is developing a multi-component vacc ine against Salmonella, Shigella and E. coli for use in human clinical trials," Sabbadini said.

Other co-authors of the study include Yen-Lin Chu of SDSU; Neil L. Berkley, co-founder of Vaxiion Therapeutics Inc. who received both M.S. and MBA degrees at SDSU; and Maria Salvato and Juan C. Zapata with the Institute of Human Virology at the University of Maryland Biotechnology Institute.

Vaxiion Therapeutics Inc. is dedicated to the intelligent design of effective vaccines and vaccine carrier technologies. Recent acts of bioterrorism, the emergence of new infectious diseases, and the development of multi-drug resistance in many types of human pathogens have spurred the demand for innovative vaccine approaches. Vaxiion's use of genetically engineered non-living bacterial minicells to deliver a multitude of protein antigens and DNA vaccines is just that...An innovative and compelling solution that promises to have broad applications against a variety of pathogens and disease indications. For more information, please visit www.vaxiion.com.

For a copy of the study, please contact Lorena Nava, with SDSU Marketing & Communications, at (619) 594-3952 or (619) 309-5179 (cell) or lnava@mail.sdsu.edu.

Contact

Vaxiion Therapeutics, Inc.
Matt Giacalone, Ph.D., M.B.A.
Business Manager
619-594-4060
mjgiacalone@vaxiion.com


'"/>




Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Researchers Discover Method for Identifying How Cancer Evades the Immune System
4. Researchers Discover Gene For Rare Skin Disorder
5. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
6. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
7. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
8. Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report
9. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
10. Researchers Urge Caution in Using ESAs for Cancer-Related Anemia
11. Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... N.J. , June 23, 2016  Guerbet announced ... Premier Inc.,s Supplier Horizon Award . ... year, Guerbet was recognized for its support of Premier ... creation through clinical excellence, and commitment to lower costs. ... to receive this recognition of our outstanding customer service ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... June 27, 2016 , ... ... to revolutionize the emergency ambulance transport experience for the millions of people who ... Uber has disrupted the taxi industry through the use of technology. Now, SmartEMS ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
Breaking Medicine News(10 mins):