Navigation Links
Vaxiion Researchers Discover Novel Vaccine Delivery System in,Collaboration with San Diego State University

SAN DIEGO--(BUSINESS WIRE)--Mar 8, 2007 - Vaxiion Therapeutics, Inc. today announced that its researchers, in collaboration with San Diego State University, have discovered a 'minicell' vaccine delivery system that has potential to protect against several disease-causing infections.

These findings were published in an advance online edition of the journal, Vaccine, and the paper was published today, in the March 8th issue.

While most vaccines contain live micro-organisms, the 'minicell' vaccine studied mimics the live pathogen response without any risk of infection, making it particularly useful for immunizing children, the elderly and those with compromised immune systems. Additionally, the minicell vaccine is able to counter many infectious diseases in a cost-effective and efficient manner, and could solve serious infectious disease problems in developing countries.

"We have found a vaccine delivery method that has an advantage over other non-living vaccines in that the minicells stimulate all elements of the immune system that are required to protect people against infectious diseases," said Kathleen McGuire, SDSU biology professor and co-author of the paper.

In the study, the SDSU team created a vaccine against the lymphocytic choriomeningitis virus (LCMV), which causes a lethal form of meningitis in mice. The minicell vaccine protected 89 percent of immunized mice from death.

"Through this research, we've been able to create a platform technology that we hope will translate into many vaccine formulations," said Vaxiion's Matt Giacalone, study co-author and a 2006 graduate of SDSU's joint MBA/Ph.D. program.

Research funding was primarily provided by Vaxiion, a biotechnology company founded by SDSU biology professor Roger Sabbadini. He also served as co-author on the study.

"Based on the success of this translational work, Vaxiion is developing a multi-component vacc ine against Salmonella, Shigella and E. coli for use in human clinical trials," Sabbadini said.

Other co-authors of the study include Yen-Lin Chu of SDSU; Neil L. Berkley, co-founder of Vaxiion Therapeutics Inc. who received both M.S. and MBA degrees at SDSU; and Maria Salvato and Juan C. Zapata with the Institute of Human Virology at the University of Maryland Biotechnology Institute.

Vaxiion Therapeutics Inc. is dedicated to the intelligent design of effective vaccines and vaccine carrier technologies. Recent acts of bioterrorism, the emergence of new infectious diseases, and the development of multi-drug resistance in many types of human pathogens have spurred the demand for innovative vaccine approaches. Vaxiion's use of genetically engineered non-living bacterial minicells to deliver a multitude of protein antigens and DNA vaccines is just that...An innovative and compelling solution that promises to have broad applications against a variety of pathogens and disease indications. For more information, please visit www.vaxiion.com.

For a copy of the study, please contact Lorena Nava, with SDSU Marketing & Communications, at (619) 594-3952 or (619) 309-5179 (cell) or lnava@mail.sdsu.edu.

Contact

Vaxiion Therapeutics, Inc.
Matt Giacalone, Ph.D., M.B.A.
Business Manager
619-594-4060
mjgiacalone@vaxiion.com


'"/>




Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Researchers Discover Method for Identifying How Cancer Evades the Immune System
4. Researchers Discover Gene For Rare Skin Disorder
5. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
6. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
7. Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
8. Dasatinib Shows High Early Response Rate as First Treatment for Chronic Myelogenous Leukemia, M. D. Anderson Researchers Report
9. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
10. Researchers Urge Caution in Using ESAs for Cancer-Related Anemia
11. Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/10/2017)... , May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of ... is based on extensive data analysis from GHI,s hospitals ... hospitals database for the region. The GHI database covers 86% ... offering more than 130 data points for each institution in ...
(Date:5/9/2017)... WASHINGTON , May 9, 2017  Demonstrating ... the board of directors for the Pharmaceutical Research ... criteria for membership. Biopharmaceutical companies will now have ... in order to be eligible to join PhRMA. ... criteria, the board is sending a clear message ...
(Date:5/6/2017)... , May 5, 2017   Provista , a ... more than 200,000 customers, today announced Jim Cunniff ... wealth of executive and business experience to Provista, including most ... pharmacy in California . He assumed his ... "Jim is a great fit for Provista," says Jody ...
Breaking Medicine Technology:
(Date:5/24/2017)... ... 2017 , ... Medic CE , a Career Step company, is sponsoring ... hosted by the Journal of Emergency Medical Services (JEMS). The free webinar, to be ... by Captain Rommie Duckworth, LP, a career fire captain as well as founder and ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... prominent for-profit and nonprofit hospitals and health systems in the nation and help ... their institutions, led professional organizations and been instrumental in developing successful hospital and ...
(Date:5/23/2017)... ... , ... Axiad IDS , a leading provider of trusted identities for ... company a “Top 25 Cybersecurity Companies 2017.” Axiad IDS received this honor ... proactively address potential cybersecurity threats before they happen. The annual list of ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... and a 2017 Best in KLAS category winner, has named Daniel P. Bullington ... extend and enhance its technology platform and product offerings,” says Justin Neece, president. ...
(Date:5/23/2017)... ... May 23, 2017 , ... Drs. Allen Huang and Jeffrey ... in Las Vegas, NV, and the importance of treating it immediately. They are ... care for peri-implantitis, with or without a referral. As experienced periodontists and implant ...
Breaking Medicine News(10 mins):