Navigation Links
Vaccine Can Prevent Cervical Cancer and Precancerous Lesions

LONDON, June 28, 2007--A cervical cancer vaccine has shown 90% efficacy for prevention of cervical cancer and precancerous lesions associated with the human papillomavirus (HPV) types targeted by the vaccine, conclude authors of an Article published early Online and in the upcoming issue of The Lancet.

HPV types 16 and 18 account for 70% or more cases of cervical cancer worldwide, but there are up to 15 oncogenic HPV types which can contribute to cervical cancer.

Professor Jorma Paavonen, Department of Obstetrics and Gynaecology, University of Helsinki, Finland, and colleagues randomly assigned 9 258 women to receive the HPV 16/18 vaccine, and 9 267 women in a control group received Hepatitis A vaccine. Women who may have already been infected with HPV were included in the study, as were women who had low-grade cytological abnormalities at study entry.

With an average follow-up of 15 months, the investigators found the vaccine had 90·4% efficacy against high-grade cervical intraepithelial neoplasia (CIN 2/3, a cervical cancer precursor) associated with HPV types 16 and 18. They found also that many CIN lesions contained several oncogenic HPV types. The level of protection against persistent infections with HPV16/18 at 6 and 12 months was 80·4% and 75·9%, respectively. The study extended earlier results of cross-protection against HPV 45 and HPV 31, which cause up to 10% of cases of cervical cancer.

The authors say: "Our results show that the vaccine is effective, well-tolerated and immunogenic in a broad population of young adult women, lending support to its potential value in preventing CIN and cervical cancer."

In an accompanying Comment, Dr Jessica Kahn, Cincinnati Children’s Medical Center, University of Cincinnati College of Medicine, USA, and Dr Robert Burk, Albert Einstein College of Medicine, New York, USA, state: "Althou gh these interim efficacy data are encouraging, their interpretation has limitations. The follow-up was brief, given that cervical carcinogenesis often evolves over several decades. They also highlight increases in adverse reactions among women in the HPV vaccine group.

Finally, the Comment authors raise the issue of ensuring the vaccine is distributed in the developing world, where cervical cancer makes the largest contribution to years of life lost to cancer, concluding: "Poverty is strongly associated with high-risk HPV infection and cervical cancer. If those who live in poverty cannot access a highly effective intervention such as HPV vaccines, disparities could worsen dramatically."

Professor Jorma Paavonen, Department of Obstetrics and Gynaecology, University of Helsinki, Finland. T) +35 8400497900

Comment Dr Jessica Kahn, Cincinnati Children’s Medical Center, University of Cincinnati College of Medicine, USA. T) +1 513 636 8587
Telephone: +44 (0)20 7424 4949/4249

Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC
3. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
4. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
5. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
6. Based on Up to 6 Years of Follow-Up, Biovest Announces Favorable Interim Blinded Data for Fast-Tracked Pivotal Phase 3 Clinical Trial of BiovaxID Anti-Cancer Vaccine for Non-Hodgkins Lymphoma
7. HepaLifes PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference
8. New Flu Vaccine from PepTcell Could Provide Immunity Against All Strains of Influenza Virus
9. Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur
10. New Flu Vaccine From PepTcell Could Provide Immunity Against All Strains of Influenza Virus
11. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
Post Your Comments:
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
Breaking Medicine Technology:
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its ... Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding ... Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, we ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
Breaking Medicine News(10 mins):