Navigation Links
Vaccine Can Prevent Cervical Cancer and Precancerous Lesions

LONDON, June 28, 2007--A cervical cancer vaccine has shown 90% efficacy for prevention of cervical cancer and precancerous lesions associated with the human papillomavirus (HPV) types targeted by the vaccine, conclude authors of an Article published early Online and in the upcoming issue of The Lancet.

HPV types 16 and 18 account for 70% or more cases of cervical cancer worldwide, but there are up to 15 oncogenic HPV types which can contribute to cervical cancer.

Professor Jorma Paavonen, Department of Obstetrics and Gynaecology, University of Helsinki, Finland, and colleagues randomly assigned 9 258 women to receive the HPV 16/18 vaccine, and 9 267 women in a control group received Hepatitis A vaccine. Women who may have already been infected with HPV were included in the study, as were women who had low-grade cytological abnormalities at study entry.

With an average follow-up of 15 months, the investigators found the vaccine had 90·4% efficacy against high-grade cervical intraepithelial neoplasia (CIN 2/3, a cervical cancer precursor) associated with HPV types 16 and 18. They found also that many CIN lesions contained several oncogenic HPV types. The level of protection against persistent infections with HPV16/18 at 6 and 12 months was 80·4% and 75·9%, respectively. The study extended earlier results of cross-protection against HPV 45 and HPV 31, which cause up to 10% of cases of cervical cancer.

The authors say: "Our results show that the vaccine is effective, well-tolerated and immunogenic in a broad population of young adult women, lending support to its potential value in preventing CIN and cervical cancer."

In an accompanying Comment, Dr Jessica Kahn, Cincinnati Children’s Medical Center, University of Cincinnati College of Medicine, USA, and Dr Robert Burk, Albert Einstein College of Medicine, New York, USA, state: "Althou gh these interim efficacy data are encouraging, their interpretation has limitations. The follow-up was brief, given that cervical carcinogenesis often evolves over several decades. They also highlight increases in adverse reactions among women in the HPV vaccine group.

Finally, the Comment authors raise the issue of ensuring the vaccine is distributed in the developing world, where cervical cancer makes the largest contribution to years of life lost to cancer, concluding: "Poverty is strongly associated with high-risk HPV infection and cervical cancer. If those who live in poverty cannot access a highly effective intervention such as HPV vaccines, disparities could worsen dramatically."

Professor Jorma Paavonen, Department of Obstetrics and Gynaecology, University of Helsinki, Finland. T) +35 8400497900

Comment Dr Jessica Kahn, Cincinnati Children’s Medical Center, University of Cincinnati College of Medicine, USA. T) +1 513 636 8587

Jorma.Paavonen@hus.fi

Jessica.kahn@cchmc.org


pressoffice@lancet.com
Telephone: +44 (0)20 7424 4949/4249
'"/>




Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC
3. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
4. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
5. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
6. Based on Up to 6 Years of Follow-Up, Biovest Announces Favorable Interim Blinded Data for Fast-Tracked Pivotal Phase 3 Clinical Trial of BiovaxID Anti-Cancer Vaccine for Non-Hodgkins Lymphoma
7. HepaLifes PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference
8. New Flu Vaccine from PepTcell Could Provide Immunity Against All Strains of Influenza Virus
9. Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur
10. New Flu Vaccine From PepTcell Could Provide Immunity Against All Strains of Influenza Virus
11. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)...  May is Stroke Awareness Month and Omron Healthcare ... methods to prevent a stroke: monitor and manage your ... and Prevention, undetected and uncontrolled hypertension is a leading ... leader in personal heart health technology, recently evolved its ... and stroke and is advancing a national public education ...
(Date:5/4/2017)... and SAN DIEGO , May 4, ... (ACOG) 2017 Annual Clinical and Scientific Meeting— OBP Medical ... medical devices, today announced the launch of a new ... OfficeSPEC and ER-SPEC vaginal specula. Already ... extra-small and extra-large sizes makes OBP Medical,s line of ...
(Date:5/3/2017)... , May 3, 2017  Kalorama Information notes ... nine percent next year and this is projected ... hematopoietic stem cell (HSCT) or bone marrow transplants ... technologies are well-suited for this task. This according ... publisher Kalorama Information. The various PCR-based methodologies, Sanger ...
Breaking Medicine Technology:
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with a dash of ... for strength training and exercise or simply lifting heavy objects, advises Dr. Kaliq Chang, ... everything,” Dr. Chang says. “Improper technique in lifting anything heavy or an attempt to ...
(Date:5/23/2017)... ... May 23, 2017 , ... Allegheny Health Network and ... Joy D’Achille Center for Women’s Behavioral Health at West Penn Hospital , a ... for women suffering from pregnancy-related depression. Construction of the Center is underway with ...
(Date:5/23/2017)... ... May 23, 2017 , ... i2i ... 2017 Best in KLAS category winner, has named Daniel P. Bullington as chief ... enhance its technology platform and product offerings,” says Justin Neece, president. “Daniel is ...
(Date:5/23/2017)... , ... May 23, 2017 , ... By all indications, ... in Sonoma County. While officials call for diligence, asking homeowners to scout for any ... potential health concerns. Along with the annoying buzz of mosquitos is the buzz associated ...
(Date:5/23/2017)... Charleston, SC (PRWEB) , ... May 23, 2017 , ... ... from Dr. Kevin Hogan, an experienced dentist practicing in Mt. Pleasant, SC, with or ... and is often recommended for patients with missing teeth in Charleston, SC. ...
Breaking Medicine News(10 mins):