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Use of Sequenom's MassARRAY System Leads to Significant Scientific,Advances in Understanding Cancer, Diabetes and Drug-Resistant,Malaria

SAN DIEGO--(BUSINESS WIRE)--Mar 14, 2007 - Sequenom, Inc. (NASDAQ: SQNM) today announced that its MassARRAY(R) technology and iPLEX(TM) assay were used by leading scientists from international research institutions and, in independent studies, significantly advanced the understanding of cancer, diabetes and drug-resistant malaria. Results from several of these studies were published in highly recognized peer-reviewed journals as follows:

-- In "High-Throughput Oncogene Mutation Profiling in Human Cancer," published in the February issue of Nature Genetics, the authors, led by scientists at Harvard and MIT, recognizing the difficulty in identifying critical genetic events across a spectrum of human tumors with enough sensitivity and scalability, utilized MassARRAY technology to assay 238 known oncogene mutations across 1,000 human tumor samples. The results enable researchers to simultaneously interrogate mutations in multiple cancer genes to guide cancer classification and therapeutic intervention.

-- In "A Genome-wide Association Study Identifies Novel Risk Loci for Type 2 Diabetes," published in the February issue of Nature, the authors, led by scientists from McGill University and Pasteur Institute, studied the association between type 2 diabetes, environmental factors and a combination of genetic variants, most of which were previously unknown. Fast track SNP Marker confirmation was performed using Sequenom's iPLEX assay.

-- In "A Common Coding Variant in CASP8 is Associated with Breast Cancer Risk," published in the February issue of Nature Genetics, the authors, led by scientists at Sheffield University Medical School, University of Cambridge and National Cancer Institute, found evidence of an association between breast cancer and CASP8 D302H. Mutations such as BRCA1 and 2 account for less than 25% of the familial risk of breast cancer. In this study, the researchers demonstrate that common
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