Navigation Links
Updated Overall Survival Data From Pivotal Herceptin Adjuvant,Studies in HER2-Positive Breast Cancer

hree weeks or weekly for 12 weeks, compared with the same regimens plus 52 weeks of Herceptin (beginning with the first dose of paclitaxel) in nearly 4,000 patients with HER2-positive breast cancer.

These results showed that the addition of Herceptin to standard adjuvant therapy continued to significantly reduce the risk of breast cancer recurrence, the primary endpoint of the studies, by 52 percent (based on a hazard ratio of 0.48) in women with HER2-positive, node-positive breast cancer, compared to patients who received standard adjuvant therapy alone. At four years of follow-up, 85.9 percent of women treated with Herceptin plus chemotherapy were disease free, compared to 73.1 percent of women treated with chemotherapy alone. The demonstrated treatment benefit of Herceptin plus chemotherapy was consistent across many important patient subgroups.

Notably, despite some patients crossing over to the Herceptin-containing arm, the additional follow-up data presented today showed an improvement in overall survival; 92.6 percent of women treated with Herceptin plus chemotherapy were still alive at four years of follow-up, compared with 89.4 percent of women treated with chemotherapy alone. This updated survival analysis showed a statistically significant 35 percent reduction in the risk of death (based on a hazard ratio of 0.65, p-value = 0.0007), which is equivalent to a 54 percent improvement in overall survival.

Each study had an independent external Data Monitoring Committee (DMC) that reviewed data from the studies, including cardiac safety data, on a regular basis. According to the investigators, serious or life-threatening (and in rare cases, fatal) cardiac events, most commonly congestive heart failure (weakening of the heart muscle), occurred approximately 3 to 4 percent more often in the Herceptin plus chemotherapy arms than in the chemotherapy alone arms. Other adverse events reported in both studies included dyspnea and interstitial pneu
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. Infinity and MedImmune Present Updated Phase I Results of IPI-504 in GIST at ASCO Annual Meeting
2. Updated Study Results Reinforce Survival Benefit of Taxotere (Docetaxel) for Men with Advanced, Hormone-Resistant Prostate Cancer
3. Introgen Reports Updated Phase 2 Advexin Data Correlating Improved Survival, Tumor Responses and Predictive p53 Biomarker
4. Vion Pharmaceuticals Presents Updated Clinical Data from a Phase II trial of Cloretazine (VNP40101M) in Patients with Relapsed or Refractory Small Cell Lung Cancer
5. Infinity and MedImmune Announce Updated Data On Ipi-504 to be Presented At ASCO
6. Avanir Pharmaceuticals Presents IEED Prevalence and Updated Zenvia Long-Term Safety Data at AAN Annual Meeting
7. Media Advisory: ACC Updated Schedule
8. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
9. Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes
10. Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen
11. Synta Presents Results for STA-4783 in Metastatic Melanoma Showing Improvement in Overall Survival
Post Your Comments:
(Date:7/2/2015)... ResMed Inc. (NYSE: RMD ) today announced that it ... 30, 2015 results on Thursday, July 30, 2015, after the ... ResMed,s results will be issued after 1:00 p.m. US Pacific ... operating results and future outlook. The earnings call ... and the live webcast of the call can be accessed ...
(Date:7/2/2015)... July 2, 2015 Releases of ... Aedes aegypti , , reduced the dengue ... Brazil by 95%, well below the modelled ... http://photos.prnewswire.com/prnh/20150630/227348LOGO) , The journal PLOS Neglected Tropical ... Oxitec,s genetically engineered mosquitoes. The results showed that in ...
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/nlfg34/cancer ) has ... Imaging and by Application - Forecast to 2020" report to ... to reach $13.1 Billion in 2020 from an estimated $7.1 Billion ... market is dominated by North America , followed ... and Rest of the World (RoW). The cancer diagnostics market in ...
Breaking Medicine Technology:ResMed to Announce Fourth Quarter and Fiscal Year-End 2015 Results 2Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 2Oxitec Mosquito Works to Control Aedes aegypti in Dengue Hotspot 3Global Cancer Diagnostics Market Report 2015 - Technology, Imaging and by Applications Forecasts to 2020 for the $13 Billion Industry 2
... , , ... presented today from the SPIRIT III pivotal U.S. clinical ... XIENCE V(R) Everolimus Eluting Coronary Stent System continued to increase ... (TAXUS). At three years, XIENCE V demonstrated a 43 percent ...
... , REYKJAVIK, Iceland, September 20 ... of DNA-Based Testing to Identify Men at,Substantially Increased Risk, and ... deCODE genetics (Nasdaq: DCGN ) today announced ... Spain, the Netherlands and,the United States have today published the ...
Cached Medicine Technology:Abbott's XIENCE V(R) Continues to Outperform TAXUS With Sustained Clinical Advantages and Impressive Long-Term Safety Results in SPIRIT III Trial 2Abbott's XIENCE V(R) Continues to Outperform TAXUS With Sustained Clinical Advantages and Impressive Long-Term Safety Results in SPIRIT III Trial 3Abbott's XIENCE V(R) Continues to Outperform TAXUS With Sustained Clinical Advantages and Impressive Long-Term Safety Results in SPIRIT III Trial 4Abbott's XIENCE V(R) Continues to Outperform TAXUS With Sustained Clinical Advantages and Impressive Long-Term Safety Results in SPIRIT III Trial 5Abbott's XIENCE V(R) Continues to Outperform TAXUS With Sustained Clinical Advantages and Impressive Long-Term Safety Results in SPIRIT III Trial 6deCODE Discovers Four New Risk Factors for Prostate Cancer 2deCODE Discovers Four New Risk Factors for Prostate Cancer 3deCODE Discovers Four New Risk Factors for Prostate Cancer 4
(Date:7/3/2015)... ... 2015 , ... Jennifer Renee Hanes, DO is the new Medical Director of ... of independent freestanding emergency rooms in the United States. , “We are excited to ... said Executive Medical Director of First Choice Emergency Room, Dr. James M. Muzzarelli. ...
(Date:7/3/2015)... , ... July 03, 2015 , ... " Selfie on ... which features the latest and coolest technology products available to consumers. Amanda Forstrom, a ... how these selfie sticks are great for documenting memories. , Almost every smartphone has ...
(Date:7/3/2015)... ... July 03, 2015 , ... Every year, One-to-1 Fitness and the Red ... of the Red Deer community with free fitness training and indoor fitness boot camp ... events and entertainment raised thousands of charity dollars and ended with a $10,000 donation ...
(Date:7/2/2015)... ... ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest ... Mississippi. The premium frozen yogurt chain was listed as #22 on the Inc. 500 ... Avenue, New Albany, MS 38652, will have a grand opening event on July 4, ...
(Date:7/2/2015)... ... 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of ... located in the Lone Star State. The premium frozen yogurt chain was listed as ... store, which opened July 1 at Duke’s Travel Plaza, is located at:, 30176 Hwy ...
Breaking Medicine News(10 mins):Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2
... 30 Paul Helmke, President,of the Brady Campaign ... the announcement yesterday by Attorney General Michael B.,Mukasey ... disqualifying mental,health records submitted to the Brady background ... emphasizes the critical need to,get all relevant records ...
... Partnership Yields Record Long Term Care Insurance Sales, ... (Amex:,NHC; NHC.PR.A), Tennessee,s most prominent marketer of long-term ... sales growth for 2007.,Long Term Care Associates, Inc., ... together, both companies have expanded their year-over-year,sales growth ...
... Testing 1 Million Angelenos Within Three Years, LOS ... Mayor Antonio Villaraigosa today as he launched the City ... 1 million Angelenos,within the next three years. The Mayor ... the Ramona Gardens community to underscore the,importance of "early ...
... disease and significantly cuts death rates, reveal the fifth year ... The figures, published ahead of print in the journal Gut, ... the Midlands. , This was the only area in England ... those aged 50 to 69, using postal tests that pick ...
... High blood-fat levels not always linked to higher stroke risk, ... link between high cholesterol and heart disease is clear to ... finds the connection between cholesterol levels and stroke is a ... 70s and 80s, the review found that high cholesterol actually ...
... Oriental,Bioengineering Inc. (NYSE: AOB ), a leading manufacturer ... that,the company will present at the ICR XChange Asia ... Conference Center in New York,City., Management,s presentation will ... located at Three Times Square in New York City. ...
Cached Medicine News:Health News:DOJ Report on Mental Health Records Shows Critical Need to Strengthen Brady System 2Health News:National HealthCare Recognized for Outstanding Sales Leadership by Long Term Care Associates, Inc. 2Health News:Mayor Antonio Villaraigosa Partners With AltaMed Health Services to Launch City of Los Angeles HIV Testing Initiative 2Health News:Bowel cancer screening halves emergency admissions and cuts deaths 2Health News:Cholesterol-Stroke Relationship Puzzles Researchers 2Health News:Cholesterol-Stroke Relationship Puzzles Researchers 3Health News:American Oriental Bioengineering to Present at the ICR XChange Asia Institutional Investor Conference 2
... SurgMaster OES Pro Resectoscope is based on ... resectoscope and enables the surgeon to perform ... exchanging the working element, HF cable and ... upgraded for resection in saline, supporting both, ...
... The world's first and only Laser ... comfortable and precisely. This innovative combination ... Intraocular Surgery. A Laser phacoemulsification device ... fragmentational energy and transmits it directly, ...
... PRECISION represents a major advance in ... focused to cover pain. This is ... you need it, anywhere along the ... independent current sources for each of ...
Used for traversing and exploring urethral strictures. The malleable tip can be shaped to desired configuration. The proximal end is threaded to attach to standard followers. Supplied sterile in peel...
Medicine Products: