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Ulcerative Colitis (UC) Sufferers Find UC Quite Disruptive to Many,Aspects of Daily Life

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PENTASA is generally well tolerated and most side effects are mild. In worldwide clinical studies, the most common side effects -- diarrhea, headache, nausea, abdominal pain, upset stomach, vomiting, and rash -- occurred less often with PENTASA than with a sugar pill. As with other medications, some serious side effects may occur. You should not take PENTASA if you are allergic to salicylates, such as aspirin. Tell your doctor if you have problems with your liver or kidneys. While taking PENTASA, visit your doctor periodically. If you have any questions about PENTASA, please talk to your doctor.

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire believes that a carefully selected portfolio of products with a strategically aligned and relatively small-scale sales force will deliver strong results.

Shire's focused strategy is to develop and market products for specialty physicians. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe.

For further information on Shire, please visit the Company's website: http://www.shire.com.

    For further information please contact:


    Media         Amanda Widtfeldt (GolinHarris)              +1 312 729 4264

                  Matthew Cabrey (Shire)                      +1 484 595 8248

GIULIANI SpA

Giuliani SpA, founded in 1889, is a privately owned specialty pharmaceutical company strategica
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