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Two-Year Results from the Medtronic ENDEAVOR III Trial Confirm,Stent's Positive Clinical Profile

olled in its multiple clinical trials, and the growing volume of positive data and number of patients with long-term follow-up continues to reinforce the stent's favorable safety and efficacy profile. The Endeavor stent is not yet approved for use in the United States.

"With two years of follow-up in nearly 1,300 patients and the volume of positive clinical data we've seen to date, we can continue to have confidence in Endeavor's clinical performance," said Martin Leon, M.D., principal investigator of the ENDEAVOR III clinical trial and Professor of Medicine at Columbia University School of Medicine. "As the Endeavor clinical program has matured, it has provided evidence that consistent and predictable patient outcomes are being sustained through time."

Scott Ward, senior vice president at Medtronic and president of the Vascular business, added: "The Endeavor clinical program continues to generate strong cumulative evidence regarding Endeavor's overall performance. Patients have been 99.7% free from overall stent thrombosis and we've seen no late stent thrombosis in our pooled clinical trials. In addition, Endeavor has demonstrated a sustained reduction in repeat procedures of 61% compared to the Medtronic Driver(R) bare metal stent and Endeavor's death/MI rates have been trending lower than bare metal stents."

Medtronic will present additional long-term data on Endeavor in the coming months. At the EuroPCR meeting in May, Medtronic will provide updated four-year and three-year results from the ENDEAVOR I and ENDEAVOR II trials respectively, as well as new data on the next-generation Endeavor Resolute drug-eluting stent. Results from the ongoing ENDEAVOR IV trial, another large randomized trial (1,548 patients) evaluating Endeavor against the Taxus stent made by Boston Scientific, are expected to be presented in the fall.

The Endeavor stent is made of a cobalt alloy and has a unique modular architecture designed to enhance deliverability
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