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Two New Imaging Studies Show Higher Dose Lipitor Stopped the,Progression of Atherosclerosis

mpared to Lipitor alone on the progression of atherosclerosis as measured by coronary intravascular ultrasound (IVUS) or carotid B-Mode ultrasound. IVUS is a relatively new, three-dimensional method of imaging to measure the total plaque volume in a cross-section of the coronary artery wall over the length of the vessel. Carotid ultrasound measures the thickness between the inner and middle layers of the carotid artery wall (IMT). All three trials had a run-in phase in which all patients were treated with Lipitor and patients' doses were titrated until individual LDL-C goals were reached. Patients were then randomized to either a combination of torcetrapib and Lipitor or Lipitor alone. Patients remained on the same dose of Lipitor for the duration of the two year study.

ILLUSTRATE

In patients with coronary heart disease randomized to Lipitor, progression of atherosclerosis was halted. Patients took an average dose of 23 mg of Lipitor (n=446). There was no significant change from baseline in percent atheroma volume (0.19%) and there was a significant regression of plaque build-up in the most diseased segment of the coronary artery (-3.3mm3).

RADIANCE 1

In patients with a genetic condition known as familial hypercholesterolemia resulting in extremely high LDL levels randomized to Lipitor, progression of atherosclerosis was halted. Patients took an average dose of 56 mg of Lipitor (n=427). There was no significant change from baseline in the IMT of the 12 carotid segments (0.0053mm/yr) nor in the common carotid artery (-0.0014mm/yr).

RADIANCE 2

Patients with high LDL and high triglycerides randomized to Lipitor experienced a progression of atherosclerosis. Patients took an average low, 13 mg dose of Lipitor (n=344). There was a significant change from baseline in the IMT of the 12 carotid segments (0.0296mm/yr) and a small but statistically significant change in the common carotid artery (0.0076mm/yr).

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