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Two New Imaging Studies Show Higher Dose Lipitor Stopped the,Progression of Atherosclerosis

red with pravastatin as measured by IVUS.

According to Dr Michael Berelowitz, Senior Vice President of Pfizer's global medical division, "These results support previous studies where higher doses of Lipitor have demonstrated impact on atherosclerosis. However, while imaging findings are scientifically interesting, we know that physicians make clinical decisions based on proven cardiovascular outcomes."

Lipitor Offers Remarkable Benefit for Stroke Patients

In a new separate analysis from a landmark clinical trial known as the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL), patients without heart disease, who had suffered a recurrent stroke or mini-stroke during the trial and took Lipitor 80 mg had a significant 53 percent reduction in the risk of major coronary events (death from cardiac causes, heart attack, or resuscitation after cardiac arrest).

"This is the first time a statin has been shown to provide coronary benefit for patients with recent stroke or mini-stroke," said Professor Henrik Sillesen, chairman of the department of vascular surgery at the University of Copenhagen in Denmark. "What is impressive is the magnitude of benefit seen with Lipitor in these high risk patients. The results show that aggressive lipid lowering with Lipitor addresses an unmet medical need."

"This adds to the wealth of scientific evidence which has consistently shown improved cardiovascular outcomes in a broad range of patients. Lipitor is the only statin that offers a unique and robust body of evidence that includes proven reductions in heart attacks and stroke, impressive average LDL lowering of 39 to 60 percent, and an established safety profile across a broad range of patients," said Dr Berelowitz.

Summary of Imaging Trials Results for the Lipitor Arm

The three, two-year clinical trials, involving over 2,800 patients were designed to investigate the efficacy of torcetrapib in combination with Lipitor co
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