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Treatment with Copaxone Plus Minocycline Showed Substantial,Reduction of Disease Activity in Patients with Active,Relapsing-Remitting Multiple Sclerosis

Patients with Relapsing Remitting Multiple Sclerosis (RRMS) Are Paralleled by Favorable Effects on MRI Markers of Disease Burden and Black Hole Evolution, evaluated whether effects on MRI markers of disease burden and tissue damage corroborate the beneficial effects on disease activity observed 15 months after initiating COPAXONE(r) therapy with a brief, low dose induction with mitoxantrone.

The abstract is accessible online at: http://www.abstracts2view.com/aan2007boston/view.php?nu=AAN07L_P06.104&terms <http://www.abstracts2view.com/aan2007boston/view.php?nu=AAN07L_P06.104&terms> .

This analysis compared patients who were randomized to receive either three months of induction treatment with mitoxantrone followed by COPAXONE(r) for 12 months (n=21) or COPAXONE(r) alone (n=19) for 15 months.

The further MRI analyses showed that the reductions in Gd-enhancing lesions and relapse activity seen at 15 months were accompanied by significant differences favoring the mitoxantrone-COPAXONE(r) group in the change from baseline in the volume of T2-weighted lesions (p=0.0139), the volume of T1-weighted lesions (p=0.0303) and the proportion of Gd-enhancing lesions that evolved into chronic black holes at month 15 (p=0.0023).

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GA Mitoxantrone Combination/Page 3

The analysis, "Tracking In Vivo Immune Modulation in MS Patients Treated with Glatiramer Acetate (GA) Alone, or with GA Preceded by Mitoxantrone, Provides Novel Insights into the Mode of Action of Therapeutic Strategies That Combine Immune Suppression and Immune Deviation" examined the mechanism of action of the combination of COPAXONE(r) and mitoxantrone versus treatment with COPAXONE(r) alone.

The abstract is accessible online at: '"/>




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