Navigation Links
Treatment with Copaxone Plus Minocycline Showed Substantial,Reduction of Disease Activity in Patients with Active,Relapsing-Remitting Multiple Sclerosis

tly used RRMS therapies due to its proven efficacy and safety and unique presumed mechanism of action," said Metz. "In previous studies, COPAXONE(R) has shown efficacy and safety both in combination with intravenous steroids and after induction with the immunosuppressant mitoxantrone; its compatibility with other compounds may make it unique among the disease modifying class of drugs and a treatment of interest for the future study of combination therapies for MS," Metz added.

About the Study

This double-blind, randomized study evaluated the safety, tolerability and efficacy of the combination of COPAXONE(R) plus oral minocycline in the treatment of RRMS patients with active disease.

Patients in this study (n=44) with one or more T1-enhancing lesions on their screening MRI were randomized to receive either COPAXONE(R) 20 mg daily plus minocycline 100 mg twice daily or COPAXONE(R) plus placebo for nine months. Patients were assessed clinically and by MRI scans at screening and months 1, 3, 8 and 9. The primary outcome was the total number of T1-enhancing lesions at months 8 and 9.

Forty patients completed the study. Groups were balanced at baseline except for greater T1-enhancing lesion number in the COPAXONE(R) plus minocycline group (median 3 versus 2; mean 7.62 versus 2.43 (p=0.07)). Despite this imbalance, treatment trended toward significance in the COPAXONE(R) plus minocycline group. At months 8 and 9, the number of T1-enhancing lesions was reduced by 63 percent (mean 1.47 versus 2.95; p=0.08) and the number of new T2 lesions was reduced by 65 percent (mean 1.84 versus 5.14; p=0.06), compared to COPAXONE(R) alone. Relapse risk rate was also non-significantly reduced in the COPAXONE(R) plus minocycline group (0.19 versus 0.41; p=NS).

About COPAXONE(R)

Current data suggest COPAXONE(R) (glatiramer acetate injection) is a selective MHC class II modulator. COPAXONE(R) is indicated for the reduction of the frequency of relaps
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Point of Care Strep Tests Speed Treatment, Lower Costs
2. Rapid HIV Testing Increases Possibility of Treatment
3. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
4. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
5. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
6. BusinessWeek Article Highlights Promising Breakthrough Treatment for Advanced Coronary Artery Disease
7. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
8. TMC125 Showed Significant Virologic Response at Week 24 in Treatment-Experienced HIV Patients With NNRTI Resistance in Phase 3 Trials
9. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
10. BusinessWeek Article Highlights Promising Breakthrough Treatment for Advanced Coronary Artery Disease
11. Peer Reviewed Journal Article Indicates Repros Proellex Exhibits Potential for New Approach to the Treatment and Prevention of Breast Cancer
Post Your Comments:
(Date:7/2/2015)... HILL, Conn. , July 2, 2015 ... Chief Executive Officer announced that Tamas Feitel ... Feitel joins Numotion after a highly successful 18 ... finance leadership roles driving strategy, profitability, and productivity to ... His most recent position was Chief Financial Officer for ...
(Date:7/2/2015)... Mass. , July 2, 2015   ... and European retinal specialists identify less frequent dosing ... edema (DME), due to the burden on both ... anti-vascular endothelial growth factor (VEGF) injections, which are ... Allergan/Molecular Partners, abicipar pegol, which is in development ...
(Date:7/2/2015)... The report "Silage Inoculants & ... Pediococcus & Enterococcus), Enzymes (Fibre-digesting & Starch-digesting), Crop-type & ... Inoculants & Enzymes Market is expected to reach $489.05 ... 2015 to 2020. Browse 75 market ... P ages and an in-depth TOC ...
Breaking Medicine Technology:Numotion Names Tamas Feitel Chief Financial Officer 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 3Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 2Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 3Silage Inoculants & Enzymes Market Worth $489.05 Million by 2020 4
(Date:7/5/2015)... MA (PRWEB) , ... July 06, 2015 , ... City ... Triathlon. City Sports will co-produce two training clinics for first-time triathletes this summer with ... clinics will take place on Thursday, July 9, at 6:00 p.m. at the North ...
(Date:7/4/2015)... ... , ... Dating a real millionaire online can be more difficult. Millionairematchapp.com ... strives to remove the worries from meeting partners. Recently, the site announced they're ... 2015 and readers have responded with excitement. , “There's quite a few millionaire ...
(Date:7/3/2015)... ... ... Food Bank will hopefully be getting a large donation of canned food items at ... SC are making it their mission to collect as many canned items as possible. Donations ... the public as well. As part of the canned food drive, these local chiropractors will ...
(Date:7/3/2015)... ... 2015 , ... Renowned rhinoplasty surgeon and Symposium Chairman, Dr. ... Symposium . To be held from March 4th - 6th, the 2016 (a previous ... Galleria Dallas. , Designed to take participants from the basic training and fundamentals of ...
(Date:7/3/2015)... ... July 03, 2015 , ... Talcum powder attorneys representing clients ... existing Talcum Powder Cancer Lawsuit Center website. Just as the previous version did, the ... , offering timely lawsuit updates and ovarian cancer warning information. The site is routinely ...
Breaking Medicine News(10 mins):Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 3Health News:MillionaireMatchapp.com Publishes the Best Millionaire Dating App and Official Dating Site Reviews 2015 2Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 2Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 3Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3
... Lab in Summit County ... Outside of ... a,cardiology testing and treatment facility located in Hudson, was recently,granted accreditation ... Accreditation of Echocardiography,Laboratories (ICAEL)., "We,re thrilled to have this accreditation, ...
... El-Deiry, MD, PhD, Professor of Medicine, Genetics, and Pharmacology ... been pursuing a cancer-targeting molecule called TRAIL and its ... and curtails tumor spread by binding to a specialized ... cancer patients who often have suppressed immunity, and for ...
... Plus PEG-INTRON Improve Efficacy and Lower Relapse Rates, ... the Disease , Higher Dose, Weight-Based Therapy Justified ... 27, 2007) -- As reported recently in the ... 5,000 patients with hepatitis C virus (HCV) showed ...
... VALLEJO, Calif., Dec. 27 Sutter Solano Medical Center,(SSMC) ... Winner. The hospital,was recognized in the Emergency Department (ED) ... scores compared to all,other facilities being measured., The ... achievement in the,health care industry that is bestowed annually, ...
... ALTO, Calif., Dec. 27 Garry W. Rogerson,President and ... the 26th,annual JPMorgan Healthcare Conference in San Francisco on ... A live webcast of the presentation will be publicly ... Go to, http://www.varianinc.com and click on "Investors." An ...
... National Institute of Environmental Health Sciences (NIEHS), part ... a total of $6.8 million for the first ... called DISCOVER - Disease Investigation Through Specialized Clinically-Oriented ... are expected to bridge the gap between basic ...
Cached Medicine News:Health News:Western Reserve Heart Care Receives ICAEL Echocardiography Accreditation 2Health News:Cell-death receptor links cancer susceptibility and inflammation 2Health News:In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment 2Health News:In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment 3Health News:In largest U.S. Hep C trial, researchers determine weight-based dosing is key to optimal treatment 4Health News:Sutter Solano Medical Center Wins National Improvement Award 2Health News:NIEHS awards DISCOVER grants 2Health News:NIEHS awards DISCOVER grants 3
The Meridian Microruptor V Nd: YAG laser system is indicated for posterior capsulotomy, peripheral iridotomy, and pupillary membranectomy procedures....
Two point fixation, tips separated by 13 mm. Each tip has 0.12 mm, 1 x 2 teeth. Wide serrated handle with thumb catch lock and dull finish....
Magnetic Farnsworth D15 kit Magnets move the color disks. Protects disks from fingerprints. Keeps all the disks in one place. Clear glass insures accurate color perception. Makes color testing fun....
... This test is a modification of the ... screening purposes rather than for the in-depth study ... benchmark to indicate a subject's ease or difficulty ... set is made up of 15 color reference ...
Medicine Products: