Navigation Links
Topline Results of Phase III Study in Acute Ischemic Stroke,(Dias-2) Do Not Demonstrate Difference Between Desmoteplase and,Placebo

NEW YORK, May 31, 2007 /PRNewswire-FirstCall/ -- Forest Laboratories, Inc. and PAION AG today announced topline results of the DIAS-2 (Desmoteplase In Acute Ischemic Stroke) study with the compound Desmoteplase. The Phase III study was designed to investigate the improvement of clinical outcome in patients with acute ischemic stroke treated with Desmoteplase within 3 to 9 hours after onset of stroke symptoms as compared to placebo. The primary efficacy endpoint (difference between active treatment and placebo in percentage of composite responders as defined below) was not met. The blinded, randomized, placebo-controlled, dose-ranging trial was jointly conducted by PAION and Forest Laboratories, Inc., and enrolled a total of 186 patients in Europe, USA, Canada, Australia, Hong Kong and Singapore. Forest Laboratories, Inc. is the partner of PAION for Desmoteplase for North America and H. Lundbeck A/S is PAION's partner for the rest of the world.

In this study, patients received either placebo (N=63), 90 mcg/kg (N=57), or 125 mcg/kg (N=66) of Desmoteplase as an intravenous bolus within 3-9 hours after the onset of stroke. Patients were eligible for treatment only in case of a distinct penumbra of at least 20% (insufficiently perfused but still salvageable tissue area around the primary location of stroke), which was confirmed by magnetic resonance imaging (MRI) or perfusion computed tomography (pCT).

The primary efficacy endpoint in the study was clinical improvement at Day 90 defined for each patient as achievement of all three of the following criteria; (1): Improvement of greater than or equal to 8 points from baseline on the National Institutes of Health Stroke Scale (NIHSS) or NIHSS score less than or equal to 1, (2): Modified Rankin Scale (MRS) score of 0-2, and (3): Barthel Index (BI) score of 75-100. Only patients who simultaneously met the criteria along all three scales were considered resp
'"/>




Page: 1 2 3 4

Related medicine technology :

1. deCODE Announces Positive Topline Results for Phase I Study of DG051 for the Prevention of Heart Attack
2. CombinatoRx Provides Topline Results from Phase 2 RA Study with CRx-139 and Very Low Dose Prednisolone
3. CV Therapeutics Announces Topline MERLIN TIMI-36 Results
4. Point of Care Cardiac Analyzers Yield Rapid Cardiac Marker Results
5. Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control
6. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
7. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
8. Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
9. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
10. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
11. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
Post Your Comments:
(Date:7/31/2015)... MOUNT PROSPECT, Ill. , July 31, 2015 ... of Pharmacy ® (NABP ® ) issued ... charged with ensuring that action is taken against ... the Internet Drug Outlet Identification Program ... 2015 , thousands of websites ...
(Date:7/31/2015)... Fla. , July 31, 2015  Xcelience, ... today that it has made a structured cash ... -based company specializing in milling, micronization and powder ... will help grow Powdersize,s business while simultaneously adding ... to Xcelience,s portfolio of capabilities. ...
(Date:7/31/2015)... -- Xencor, Inc. (NASDAQ: XNCR ), a clinical-stage biopharmaceutical ... autoimmune diseases, asthma and allergic diseases, and cancer, today ... to its board of directors. "Yujiro,s ... a tremendous asset to our board," said Bassil ... Xencor. "Xencor faces a range of opportunities for our ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3
... Oct. 21 Flextronics (Nasdaq: FLEX ) is ... agreement to acquire Slomedical S.R.O through a share purchase ... medical devices ranging from tubing sets to complex devices ... before the end of the calendar year, pending required ...
... Oct. 21 More than 25 Eli Lilly and Company ... celebrate "Energy Day," which is a new corporate sustainability effort ... reduction goals and to encourage sustainable behaviors. , ... early. Over a five-year period, from 2004 to 2008, Lilly ...
Cached Medicine Technology:Flextronics Announces Expansion of Medical Disposables Offering 2Lilly Surpasses Energy Efficiency Goals and Celebrates Worldwide Energy Day 2
(Date:7/31/2015)... Tenn. (PRWEB) , ... July 31, 2015 , ... The ... Robert Church Park in Downtown Memphis on October 3, 2015. The Ride to Fight ... focused on cancer research between Methodist Healthcare, The West Clinic and The University of ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to enjoy ... comes time to cook the next meal, making July the most appropriate to be ... grilling tips and recipes. , Make the next cookout different than the ones in ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... Rally Insurance Group, Inc. has re-branded their social media profiles to better connect ... way for consumers to communicate, find information, share insights and opinions. The Rally ...
(Date:7/31/2015)... ... July 31, 2015 , ... M3 USA MDLinx.com, source ... launch three new Board Exam Courses. , The additions of Gastroenterology, Pulmonology and ... Prep from MDLinx makes preparing for the exam easy and painless. MDLinx offers ...
(Date:7/31/2015)... CA (PRWEB) , ... July 31, 2015 , ... According to the article ... floor of the Pasadena courthouse was contained and extinguished by the city’s fire department before ... in the building at the time of the fire, and it was a fire alarm ...
Breaking Medicine News(10 mins):Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3
... to reach 8.3 million by the year 2030, with ... more is done to tighten trans-border controls on the ... two epidemics that are encountering a major increase in ... the HIV/AIDS epidemics," said Douglas Bettcher, director of the ...
... that POM Wonderful 100 pct Pomegranate Juice has beneficial ... the blood flow to the penis during sexual stimulation. ... examined the efficacy of pomegranate juice versus placebo in ... ,Mild ED is defined as the mildly decreased ability ...
... Dram, Scotland's national drink, is on sale for 1,000 pounds a ... in Perthshire, the rare Johnnie Walker 1805 has just gone on ... 200 bottles have been made to celebrate the birthday of the ... the makers claim, by the fact the majority of the nine ...
... US vice president and presently a high profile environmentalist, will ... ,He is behind the Live Earth program - ... various artists planned to take place on Saturday July 7, ... , The concerts have the intent of bringing ...
... District after over 100 people reportedly tested HIV positive. ... out of their village to nearby cities in search of ... ,The remote village fraught with poverty, illiteracy, unemployment and ... were reported in the last four years. , ...
... effective alternative treatment for sufferers of crippling rheumatoid arthritis, ... and Denmark. ,Severely affected patients already being ... capsules of rosehip powder for six months, a pilot ... more extensive trials, which could form the basis of ...
Cached Medicine News:Health News:Annual Tobacco-related Deaths to Reach 8.3 Million by 2030 2Health News:Pure Pomegranate Juice Helps Reverse Erectile Dysfunction Function 2Health News:Scot's National Drink, Now Available at 1,000 Pounds a Nip 2Health News:Live Earth Will Make the World More Aware of the Crisis Facing the Earth, Hopes Al Gore 2Health News:Live Earth Will Make the World More Aware of the Crisis Facing the Earth, Hopes Al Gore 3Health News:Jharkhand Village Shocked to Know About Its Huge HIV Positive Population 2Health News:Rosehips may Be an Effective Alternative for Rheumatoid Arthritis 2
... imaging agent that is labeled with technetium ... and localization of regions of reversible myocardial ... infarction under exercise and rest conditions. Imaging ... or up to 4 hours after administration ...
Universal Hub with Varying Blade Edge Diameters For Mounting the Blade to the Handle; Stainless Steel....
... Chloride Tl 201 Injection is supplied in ... diagnostic radiopharmaceutical for intravenous administration. Each milliliter ... Tl 201 at calibration time, made isotonic ... with 0.9% (v/v) benzyl alcohol. The pH ...
Elongated Loop, Slightly Curved; in Stainless Steel....
Medicine Products: