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Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work,Productivity in Patients with Rheumatoid Arthritis

of the onset of the disease. RA can interfere with a person's ability to work due to joint pain, fatigue and joint tenderness and damage. Several studies have shown that patients with RA have limited employment possibilities and reduced productivity at work.

    Study Highlights:

    -- PROWD is a multi-center, randomized, 56-week controlled trial that

       examined the effect of HUMIRA plus MTX versus placebo plus MTX on job

       loss due to all causes and imminent job loss in 148 early RA patients.

       Although the changes in job loss related to all causes -- not specific

       to disability alone -- did not reach significance between weeks 16 and

       56, results showed that significantly more patients on MTX alone

       reported job loss compared to patients taking HUMIRA plus MTX during

       the entire period of 56 weeks (40 percent vs. 19 percent).  The

       investigators concluded that HUMIRA plus MTX reduced RA-related job

       loss and reduced work time lost in patients with early RA more than MTX

       alone.


    -- DE032 is an economic companion study to PREMIER, a two-year,

       double-blind controlled study that compared the effectiveness of

       HUMIRA, MTX and the combination of the two drugs in treating early RA.

       The DE032 study compared HUMIRA plus MTX (n=219) to MTX alone (n=214)

       on patient-reported measures of work performance in both paid workers

       and homemakers.  Results showed that after two years, paid workers and

       homemakers taking MTX alone missed significantly more workdays than

       patients taking HUMIRA plus MTX (26 vs. 15 and 14 vs. 7, respectively).

       In addition, patients on HUMIRA plus MTX were 21 percent more likely to

       gain or retain employment compared to patients on MTX alone at the end

       of two years.


    -- DE033, an open label DMARD registry controlled study, examined the

       long-term impact on employment tenure and likel
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