Navigation Links
The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer

Presentation at ASCO Plenary Session Reports EORTC 40983 (EPOC) Intergroup Study Results

CHICAGO, June 04, 2007 /PRNewswire-FirstCall/ -- Results of the randomized phase III EORTC 40983 Intergroup study, or EPOC study, demonstrate for the first time that peri-operative (pre and post surgery) FOLFOX4 (Eloxatin(R) (oxaliplatin injection) in combination with a standard chemotherapy regimen for colon cancer, 5-fluorouracil/leucovorin (5-FU/LV)) given to patients with resectable liver metastases from colorectal cancer significantly improved Progression-Free Survival (PFS) compared to surgery alone. (PFS is the time from the start of therapy until disease progression or death). The EPOC study results were presented today at the Plenary Session of the 43rd Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL.

At a median follow-up of three years, FOLFOX4 treatment given before and after surgery significantly improved PFS by 9.2% and reduced the risk of relapse by 27% (HR=0.73, p=0.025) among patients for whom resection was successful. When evaluating results among all randomized patients, including the 61 patients who were not able to undergo liver metastases resection or were ineligible, FOLFOX4 did not significantly improve PFS compared to surgery alone (7.2% absolute difference, p=0.058). However, when taking into account all eligible patients (171 in each arm), even those not resected, FOLFOX4 treatment significantly improved PFS by 8.1% and reduced the risk of relapse by 23% (H=0.77, CI:0.60-1.00 ; p=0.041).Results showed that FOLFOX4 given before resection did not prevent patients' ability to undergo surgery.

The most common adverse events were with preoperative chemotherapy: diarrhea (Grade3: 8.2%), sensory neuropathy (Grade3: 2.3%), neutropenia (Grade3/4:18.1%); and with post-operative chemotherapy: sensory neuropathy (Grade3: 9.6%), neutropenia (Grade3/4: 34.8%). The
'"/>




Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. MabThera Significantly Increases Survival of Lymphoma Patients Regardless of Chemotherapy Regimen
2. Data Presented at AACR Meeting Show Peregrines Bavituximab Equivalent Can Generate Curative Immune Responses as Part of a Vaccine-Like Regimen in Preclinical Models of Aggressive Brain Cancer
3. Arterial Plaque Significantly Reduced in Women Age 50-59 Taking Hormones, Says New Analysis of Womens Health Initiative Data
4. Prexige Study Shows Significantly Less Impact on Blood Pressure Than Ibuprofen in Osteoarthritis Patients with Controlled Hypertension
5. Lumiracoxib Study Showed Significantly Less Impact on Blood Pressure Than Ibuprofen in Osteoarthritis Patients with Controlled Hypertension
6. Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid Arthritis Compared to a Current Standard of Care
7. Next Safety, Inc.s Innovative Drug Delivery System Will Replace Cigarettes and Significantly Advance Pulmonary Medication Delivery
8. Ivivis PEMF Technology Significantly Improves Neuron Survival in Parkinsons Disease Model, Study Finds
9. Mercks Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study
10. Nexavar Significantly Extends Overall Survival by 44% in Liver Cancer Patients
11. MabThera Significantly Extends Survival And Cures More Patients With Aggressive Lymphoma Than Chemotherapy Alone
Post Your Comments:
(Date:6/3/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/t3kkhg/the_future_of ) has ... of Pharmaceutical Outsourcing" report to their offering. ... need to develop better drugs with high success ... increasingly utilizing external resources to increase their efficiency ... internal operation. Their outsourcing demands and proportions have ...
(Date:6/3/2015)... Medical Systems (NYSE: VAR ), world leader in radiotherapy ... the Middle East with the creation ... . Varian Medical Systems Arabia, the result of a ... today at a ceremony attended by local dignitaries and Varian,s ... represents the next step in our commitment both to cancer ...
(Date:6/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/snzzg5/2015_strategies ... "2015 Strategies in the US Tumor Marker Testing ... Highlights of the Report Include , ... testing market. , Major issues pertaining to ... economic, regulatory, demographic, social and technological trends with ...
Breaking Medicine Technology:The Future of Pharmaceutical Outsourcing: 2015 Report 2Varian Establishes Local Entity in Saudi Arabia to Support Expansion in Middle East 2United States Strategies in the Tumor Marker Testing Market 2015 2
... The American Consumer Institute Center for Citizen Research (ACI) ... Commission (FTC) expressing concerns about the proposed merger between ... benefit management (PBM) companies.  The two PBMs announced a $29 ... soon as early 2012. "Approving this mega-PBM ...
... Fleming Pharmaceuticals announced today that, effective December 22, ... Ocean®, Nephrocaps®, Magonate® and ProBarimin QT® products to Valeant ... Valeant Pharmaceuticals North America LLC, to act as distributor ... Fleming also manufactures contract products for a broad customer ...
Cached Medicine Technology:American Consumer Institute Warns FTC: ESI/Medco Deal Poses Significant Anticompetitive Risks 2
(Date:6/3/2015)... A group of nine authors involved with ... Inspire Award at DIA’s upcoming Annual Meeting. DIA’s Global ... their leadership, level of excellence, and commitment to service ... of the Author(s) of the Year Award, which acknowledges ... made a significant impact in advancing medical product development, ...
(Date:6/3/2015)... 03, 2015 Visual BI Solutions, ... today announced the launch of the second release ... SAP® BusinessObjects™ Design Studio. The Design Studio EXtension ... and advanced functionalities into their dashboarding projects. , ... Visual BI is adding key components for customers ...
(Date:6/3/2015)... June 03, 2015 Sitting at a ... discomfort in the back, neck, shoulders and/or wrists. This ... injuries. In addition, recent research links sitting for long ... chronic diseases. Fortunately, three inventors from Oakville, Ontario, are ... a desk. , They have developed a prototype for ...
(Date:6/3/2015)... 2015 Fourroux Prosthetics, located at 6630 ... celebrate its grand opening with a ribbon cutting ceremony ... center of its kind in the area, Fourroux Prosthetics ... and outcomes through use of patented advanced prosthetics CAD/CAM ... of Fourroux Prosthetics, states, “Our goal has always been ...
(Date:6/3/2015)... TX (PRWEB) June 03, 2015 ... independent freestanding emergency rooms in the United States, announced ... Potranco facility in late June. , “I am ... in Texas with a new facility in the San ... Director of First Choice Emergency Room. , First ...
Breaking Medicine News(10 mins):Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 2Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 3Health News:Authors Representing TransCelerate BioPharma Inc. to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 4Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 2Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 3Health News:Adjustable Height Tabletop Unit Invented by Three InventHelp® Clients (TOR-9278) 2Health News:Fourroux Prosthetics Atlanta to Have Grand Opening Gala & Ribbon Cutting Ceremony 2Health News:First Choice Emergency Room to Open New Facility in San Antonio, Texas 2
... , CHICAGO and RALEIGH, N.C., Aug. ... focused exclusively on the awareness, testing and conversation of ... transmitted infection (STI) education and advocacy organization is now ... , , Since 1914, the ...
... , , SANTA MONICA, Calif., ... Kent Conrad (D-ND) and a number of Senate conservatives have been ... they would not have the market clout to leverage discounts and ... a path to gutting state consumer protection laws, according to the ...
... Decline seen as sign of progress against drug-resistant ... Prescribing antibiotics to treat respiratory tract infections has ... has found. , That,s mainly the result of ... according to the researchers. But despite a decline ...
... Gardasil, study finds, , TUESDAY, Aug. 18 (HealthDay News) ... a cause of cervical cancer, appears safe, with relatively ... government study. , The study, which included data ... found that the rate of serious adverse events for ...
... ... automating claims processing with Corticon Business Rules Platform , ... Redwood City, CA (PRWEB) August 18, 2009 -- Corticon Technologies ... project: American Community Mutual Insurance Company® (ACMIC) has gone live with an ...
... , , , ... and Aging has released "Technologies To Help Older Adults Maintain ... technology areas with significant potential of improving chronic health care ... care costs. , , "Spending on ...
Cached Medicine News:Health News:Confidential Online STD Testing Clinic, GetSTDTested.com, Strengthens Partnership With ASHA in the Fight Against STDs 2Health News:Confidential Online STD Testing Clinic, GetSTDTested.com, Strengthens Partnership With ASHA in the Fight Against STDs 3Health News:Sen. Conrad's Health Insurance Co-Ops Won't Provide Affordable Care and Could be Used by the Insurance Industry Against Americans, Says Consumer Watchdog 2Health News:Sen. Conrad's Health Insurance Co-Ops Won't Provide Affordable Care and Could be Used by the Insurance Industry Against Americans, Says Consumer Watchdog 3Health News:Sen. Conrad's Health Insurance Co-Ops Won't Provide Affordable Care and Could be Used by the Insurance Industry Against Americans, Says Consumer Watchdog 4Health News:Antibiotics Being Prescribed Less for Respiratory Infections 2Health News:Antibiotics Being Prescribed Less for Respiratory Infections 3Health News:Cervical Cancer Vaccine Seems Safe 2Health News:Cervical Cancer Vaccine Seems Safe 3Health News:American Community Mutual Insurance Company (ACMIC) Selects Corticon 2Health News:American Community Mutual Insurance Company (ACMIC) Selects Corticon 3Health News:American Community Mutual Insurance Company (ACMIC) Selects Corticon 4Health News:Center for Technology and Aging Brief Reviews Technologies That Improve Chronic Care and Help Older Adults Maintain Independence 2Health News:Center for Technology and Aging Brief Reviews Technologies That Improve Chronic Care and Help Older Adults Maintain Independence 3
... cover the range from 2ul to 5000ul. ... lock design prevents inadvertent volume change. Novel ... Whole pipette is autoclavable at 121C(250F). To ... Suitable for one-handed operation. Auto or ...
... the #1 Pipettor for sub-microliter pipetting ... reliability. Continuously adjustable. Features lPLUS, a ... interchangeable ejector buttons to fit large ... pipet tip ejector with three different ...
... The Finnpipette Digital offers improved ergonomics ... rounded handle, modified grippy finger rest ... operator comfort and efficiency. Finnpipette Digitals ... power-boosted gearing mechanism (pat. pend.) and ...
A Biplane Pediatric TEE transducer....
Medicine Products: