( to obtain additional safety and pharm...)Thallion Announces Publication of ECO-4601 Phase I/II Clinical Data,at ASCO,Health

The clinical study was conducted at the Segal Cancer Centre, Jewish General Hospital, McGill University in Montreal in conjunction with Thallion Pharmaceuticals Inc. The abstract is titled:

“Phase I study of ECO-4601, a novel Ras pathway inhibitor.” Abstract No. 14128 by P. Kavan, D. Melnychuk, A. Langleben, S. D. Baker, A. Bangash, C. Gauthier, M. Ranger, H. Gourdeau, M. D. Harvey, P. Falardeau and G. Batist. Journal of Clinical Oncology, Volume 24, Issue 18S.

About ECO-4601 ECO-4601 is a novel small molecule derived from a nonpathogenic microorganism. It has demonstrated broad in vitro cytotoxic activity across a diverse panel of tumour cell lines and in vivo efficacy in a number of xenograft tumour models. Preclinical data suggest that ECO-4601 is a targeted anti-cancer agent with dual activity: selective binding to the peripheral benzodiazepine receptor (PBR) and inhibition of the Ras- MAPK pathway. ECO-4601 was discovered using DECIPHER®, Thallion’s proprietary genomics-based drug discovery platform.

About Thallion Pharmaceuticals Inc. Thallion Pharmaceuticals Inc. (TSX: TLN) is a biotechnology company developing pharmaceutical products in the areas of infectious disease and oncology. Thallion’s clinical-stage programs include: Shigamabs®, a dual antibody product for the treatment of Shigatoxin-producing E. coli bacterial infections; ECO-4601, a novel anticancer therapy derived from a nonpathogenic microorganism; and CAP-232, a targeted therapy with potential efficacy in multiple oncology indications. Thallion has two proprietary technology platforms: CellCarta®, a proteomics discovery engine, and DECIPHER®, a genomics-based discovery platform. Thallion Pharmaceuticals was formed on March 14, 2007 by the amalgamati
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