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Thallion Announces Publication of ECO-4601 Phase I/II Clinical Data,at ASCO

MONTRÉAL, June 1, 2007 – Thallion Pharmaceuticals Inc. (TSX: TLN) announced today that preliminary data from its Phase I/II clinical trial investigating ECO-4601 in advanced cancer patients was published in abstract form as part of the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois. In the Phase I dose escalation portion of the study, 14 patients (ten colorectal, two ovarian, one duodenal and one glioma), that had completed and not responded to the respective standard of care therapy, were treated with ECO-4601. The product was well tolerated and a maximum tolerated dose (MTD) was not attained. Each of these 14 patients received from one to eight cycles of treatment, with seven patients completing at least three cycles. Of these seven evaluable patients, six demonstrated stable disease (four colorectal, one ovarian, one duodenal).

“The excellent safety profile and the promising signals of clinical efficacy give us confidence in the potential of ECO-4601 as we move forward with our clinical development program,” said Dr. Pierre Falardeau, Chief Operating Officer of Thallion Pharmaceuticals Inc. “We continue to enroll patients as part of the extension portion of the study and anticipate announcing additional efficacy results later this year.” The Phase I/II clinical trial was designed to examine the safety, pharmacologic profile and anti-tumour efficacy of ECO-4601 for the treatment of advanced cancer patients. ECO-4601 was administered in 21 day cycles consisting of a two week continuous intravenous infusion followed by a one week rest period. The first portion of the Phase I/II trial is a dose escalation study with doses ranging from 30 to 480mg/m2/day to assess the safety, pharmacokinetics and MTD of ECO-4601. The second portion of the Phase I/II trial is an extension phase which includes up to 15 additional patients treated at the highest dose, as determined in the first portion of the study
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