Navigation Links
Telomerase Presentations at the AACR 2007 Annual Meeting

>

Cancer Stem Cells

Cancer stem cells (CSCs) are a rare sub-population of self-renewing, immortal tumor cells capable of differentiating into the various types of cells seen within the bulk tumor. They are now widely believed to be distinct from the bulk tumor cells and to be responsible for many cases of drug resistance and cancer recurrence. The 2007 AACR meeting had a dramatic increase in CSC presentations, and there is a growing awareness that effective cancer treatment will require drugs that kill CSCs.

At previous cancer meetings, Drs. W. Matsui and R. Jones of Johns Hopkins University reported on telomerase activity in myeloma stem cells. The Johns Hopkins team demonstrated that Geron's telomerase inhibitor, GRN163L, blocked growth and colony formation in both the stem and differentiated subpopulations of myeloma cells. In these studies, no other compounds have been shown to be as active against myeloma CSCs. Geron is currently planning a trial with GRN163L in myeloma patients.

Other Telomerase and Telomere Presentations

Other studies presented at the AACR meeting focused on the degree of telomere loss prior to telomerase activation in various tumor types, the role of telomere dysfunction in tumorigenesis, and use of the telomerase promoter to drive tumor cell death.

"The data presented at AACR contribute to the growing body of evidence regarding the importance of telomerase targeted therapies for the treatment of cancer," noted Alan Colowick, M.D., M.P.H., Geron's president, oncology. "Geron currently has two clinical studies of GRN163L underway in patients with chronic lymphocytic leukemia (CLL) and solid tumor malignancies. We plan to initiate two additional studies of GRN163L in patients with multiple myeloma and non-small cell lung cancer, as well as a study of GRNVAC1 in patients with acute myelogenous leukemia (AML), in the months ahead.

Geron is developing first-in-class biopharmaceuticals for the treatment
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits
2. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
3. Generex Biotechnology to Make Presentations At 46th Annual Meeting of the European Society of Pediatric Endocrinology
4. Nuvelo Announces Presentations on rNAPc2 and NU172 at the XXIst Congress of the International Society on Thrombosis and Haemostasis
5. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
6. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois
7. Inspire Announces Presentations at Two European Scientific Conferences
8. Presentations at 2007 European Stroke Congress Highlights New Direction for Viprinex (ancrod)
9. IDM Pharma Announces UVIDEM(R) and EP-2101 Data Presentations at 2007 ASCO Annual Meeting
10. MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
11. Pharmacyclics Announces Presentations and Published Abstracts on Xcytrin at The 2007 American Society of Clinical Oncology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Telomerase Presentations the AACR Annual Meeting
(Date:8/29/2014)... , Aug. 29, 2014   Vittamed Corporation , a ... announced today that T. (Teo) Forcht Dagi , ... company,s Board of Directors. " Teo Forcht ... in neurosurgery, medical innovation and venture capital," said Remis ... delighted to add his clinical, strategic, and entrepreneurial expertise to ...
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely eradicated ... generation ago are returning. Measles was declared eliminated in ... 2014 as of August 15—the highest incidence in 20 ... health department declared whooping cough a problem of ... getting sick and dying from these preventable diseases—in part ...
(Date:8/29/2014)... /PRNewswire-iReach/ -- ChemImage will present a workshop focused on ... Forensic Science Society,s 22 nd International Symposium ... Australia .  Forensic Scientists will be in ... imaging can bring to examination procedures. ... Product Development at ChemImage, will host a workshop ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... Tengion, Inc. (Nasdaq: TNGN ), a leader in ... as its President and Chief Executive Officer. Most recently, Mr. ... and Chief Executive Officer of CCS Medical, Inc., a company ... services for patients with chronic diseases, from 2008 until completion ...
... Accuray Incorporated (Nasdaq: ARAY ), the premier ... scheduled to present at the Oppenheimer Healthcare Conference in ... 1:00 p.m. EST/10:00 a.m. PST.  A ... from the Investor Relations page of the Company,s website ...
Cached Medicine Technology:Tengion Appoints John L. Miclot President and Chief Executive Officer 2Tengion Appoints John L. Miclot President and Chief Executive Officer 3Tengion Appoints John L. Miclot President and Chief Executive Officer 4
(Date:8/30/2014)... (PRWEB) August 30, 2014 Jake W., 18, ... while in the Back2Basics Outdoor Adventures transition program ... finish high school so I can actually start on a ... and math, and I'm done.” , He has six months ... Back2Basics program. Most clients choose to continue on to the ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 “In 2013, a ... The Jones Firm says in a recently released article on ... person was injured in an auto accident every 12 minutes, ... minutes,” they continue. “Based on the 2013 statistics, between now ... vehicle collision.” , The threat of an auto accident is ...
(Date:8/30/2014)... Miami, FL (PRWEB) August 30, 2014 Zensah®, ... new Camo Compression Leg Sleeve . The camo sleeves ... Compression Leg Sleeve collection. The camo line includes classic ... purple and magenta. , Known as tibial stress syndrome, ... side of the lower leg. Swollen and irritated muscles, stress ...
(Date:8/30/2014)... Barton Associates, an industry leading physician, ... , announces a new office location in Keene, NH, ... headquartered in Peabody, MA, with additional staffing centers in ... Jupiter, FL. , Barton Associates made the decision to ... crisis affecting the United States, a crisis that will ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 What challenges ... What are the latest trends, concerns, and considerations? ... Dr. Ken Pendleton recently spoke with Woody Wommack, Southeast ... of current issues in football recruiting. Notably, Wommack ... younger athletes, changes that he thinks are coming as ...
Breaking Medicine News(10 mins):Health News:Startling Washington Auto Accident Statistics Discussed In Recently Released Article By The Jones Firm 2Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2Health News:Barton Associates to Open a New Office Location in Keene, NH 2Health News:Woody Wommack of Rivals.com Discusses the World of NCAA Football Recruiting on SCI TV 2Health News:Woody Wommack of Rivals.com Discusses the World of NCAA Football Recruiting on SCI TV 3
... by Nancy Speck, PhD, professor of Cell and Developmental ... University of Pennsylvania, has discovered a molecular marker for ... in the developing embryo, which provides much-needed insights for ... in the bone marrow of adult mammals, generate all ...
... populations with a low prevalence of tuberculosis (TB), the ... in the U.S for the diagnosis of TB ... "We compared commercially available tests for latent tuberculosis ... LTBI prevalence," said James Mancuso, MD, DrPH, of the ...
... HealthDay Reporter , THURSDAY, Dec. 8 (HealthDay News) -- ... the known cosmetic and psychological advantages, a new study ... women with DCIS (ductal carcinoma in situ, an early ... Hershman, an associate professor of medicine and epidemiology at ...
... 8 (HealthDay News) -- New guidelines on treating so-called "latent" ... simplify the course of the therapy from about 9 months ... Control and Prevention. The new guidelines for public health ... expert opinion and the results of three clinical trials -- ...
... one of the coauthors of a new paper by a group ... for strong steps to be taken to control the global crisis ... of steps that need to be taken on a global scale ... a meeting the group held at the Banbury Conference Centre in ...
... Ga. A study that may help personalize pain ... at Georgia Health Sciences University. Dr. Cheedy Jaja, ... Nursing, has received a three-year National Institutes of Health ... play a role in metabolizing opioids could help physicians ...
Cached Medicine News:Health News:Penn study unlocks origins of blood stem cells 2Health News:Discordance among commercially-available diagnostics for latent TB infection 2Health News:Few Women Get Breast Reconstruction After Mastectomy: Study 2Health News:Few Women Get Breast Reconstruction After Mastectomy: Study 3Health News:CDC Issues New TB Treatment Guidelines 2Health News:New paper calls for strong steps to tackle antibiotic resistance 2Health News:Study probes genetic link to sickle cell pain management 2Health News:Study probes genetic link to sickle cell pain management 3Health News:Study probes genetic link to sickle cell pain management 4
... Radiation Protection Goggles fit ... be used by the ... leaded glass, 1.0 mm ... provide increased scatter radiation ...
QualCraft™ Euro Lite has a molded nylon frame that fits most faces. Universal keyhole nose bridge fits narrow to average noses. Available with or without lead vinyl-lined side shields....
QualCraft™ Radiation Protection Eyewear providex maximum comfort and eye protection! Lenses made of 0.75 mm leaded glass. Side shields of 0.30 mm leaded acrylic help seal out scatter radiation ...
Qualcraft™ Radiation Readers, Wraparound Glasses. Protect yourself and have close-vision clarity....
Medicine Products: