Navigation Links
Telomerase Presentations at the AACR 2007 Annual Meeting

>

Cancer Stem Cells

Cancer stem cells (CSCs) are a rare sub-population of self-renewing, immortal tumor cells capable of differentiating into the various types of cells seen within the bulk tumor. They are now widely believed to be distinct from the bulk tumor cells and to be responsible for many cases of drug resistance and cancer recurrence. The 2007 AACR meeting had a dramatic increase in CSC presentations, and there is a growing awareness that effective cancer treatment will require drugs that kill CSCs.

At previous cancer meetings, Drs. W. Matsui and R. Jones of Johns Hopkins University reported on telomerase activity in myeloma stem cells. The Johns Hopkins team demonstrated that Geron's telomerase inhibitor, GRN163L, blocked growth and colony formation in both the stem and differentiated subpopulations of myeloma cells. In these studies, no other compounds have been shown to be as active against myeloma CSCs. Geron is currently planning a trial with GRN163L in myeloma patients.

Other Telomerase and Telomere Presentations

Other studies presented at the AACR meeting focused on the degree of telomere loss prior to telomerase activation in various tumor types, the role of telomere dysfunction in tumorigenesis, and use of the telomerase promoter to drive tumor cell death.

"The data presented at AACR contribute to the growing body of evidence regarding the importance of telomerase targeted therapies for the treatment of cancer," noted Alan Colowick, M.D., M.P.H., Geron's president, oncology. "Geron currently has two clinical studies of GRN163L underway in patients with chronic lymphocytic leukemia (CLL) and solid tumor malignancies. We plan to initiate two additional studies of GRN163L in patients with multiple myeloma and non-small cell lung cancer, as well as a study of GRNVAC1 in patients with acute myelogenous leukemia (AML), in the months ahead.

Geron is developing first-in-class biopharmaceuticals for the treatment
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits
2. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
3. Generex Biotechnology to Make Presentations At 46th Annual Meeting of the European Society of Pediatric Endocrinology
4. Nuvelo Announces Presentations on rNAPc2 and NU172 at the XXIst Congress of the International Society on Thrombosis and Haemostasis
5. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
6. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois
7. Inspire Announces Presentations at Two European Scientific Conferences
8. Presentations at 2007 European Stroke Congress Highlights New Direction for Viprinex (ancrod)
9. IDM Pharma Announces UVIDEM(R) and EP-2101 Data Presentations at 2007 ASCO Annual Meeting
10. MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
11. Pharmacyclics Announces Presentations and Published Abstracts on Xcytrin at The 2007 American Society of Clinical Oncology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Telomerase Presentations the AACR Annual Meeting
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon Solution, ... advanced memory and analog IC solutions, today announced that ... July 24, 2014, at 7:00 a.m. Pacific Time (10:00 ... for the fiscal 2014 third quarter ended June 30, ... telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time on ...
(Date:7/10/2014)... , July 10, 2014  Valeant Pharmaceuticals International, Inc. ... announced it has completed the sale to Galderma of ... owned or held by Valeant for $1.4 billion in ... S.A, which recently completed its acquisition of Galderma. ... of our products to a company that is firmly ...
(Date:7/10/2014)... WOONSOCKET, R.I. , July 10, 2014 CVS ... its board of directors has approved a quarterly dividend of ... The dividend is payable on August 1, 2014, to holders ... Caremark CVS Caremark is dedicated to helping ... integrated pharmacy company in the United States ...
Breaking Medicine Technology:
(Date:7/11/2014)... surgery to repair damage to the anterior cruciate ligament (ACL) ... -- could increase a young athlete,s risk for further injuries, ... patients, aged 8 to 16, who had ACL reconstruction surgery. ... after their injury, 37 had surgery six to 12 weeks ... after their injury. The youngsters who had surgery later ...
(Date:7/11/2014)... CA (PRWEB) July 11, 2014 Ticket ... Bryan Tickets at the Sleep Train Amphitheatre in Wheatland, ... venues that can compare to what the Sleep Train Amphitheatre ... musical events and special attractions over the course of its ... 16th, the Sleep Train Amphitheatre in Wheatland (Sacramento metro area) ...
(Date:7/11/2014)... The “Proteomics Market by Technology (Protein Microarray, Mass ... X-ray Crystallography) - Instruments, Reagents & Services - ... major market drivers, restraints, and opportunities in North ... World (RoW). , The proteomics market has experienced ... due to the increasing need of proteomic outcomes ...
(Date:7/11/2014)... who screened positive for a history of hazardous or ... 50 percent after receiving mobile phone text messages following ... study published online yesterday in Annals of Emergency ... Young Adult Emergency Department Patients: A Randomized Clinical Trial ... 50,000 adults ages 18 to 24 visit ERs and ...
(Date:7/11/2014)... By Steven Reinberg ... -- Stress, hostility and depression may increase the risk for ... depression seemed to raise the risk of a stroke or ... also found that stress apparently raised stroke or TIA risk ... said. A TIA is a mini-stroke caused by a temporary ...
Breaking Medicine News(10 mins):Health News:Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 2Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 4Health News:Text message medicine: Texts from the ER can reduce binge drinking 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 3
... SCHAUMBURG, Ill., May 12 For the estimated ... important fashion accessory,that many women wear, and change, daily. ... more than they bargained for when purchasing,inexpensive earrings. Nickel ... on the earlobes and repeated exposure can make treatment,difficult., ...
... investigation after efforts uncover ... system abuse, ... New York State in 2007. With so many recipients and,providers involved, the ... fraud, waste, and abuse., Over the last two years, Salient Corporation, ...
... for event -, MCLEAN, Va., May 12 ... more effective than real, live dogs or cats ... other aging-related,illnesses?, Come find out Monday, June ... Community (VHRC) in McLean, Va., hosts an industry ...
... its,Distinguished Americans series, the U.S. Postal Service released ... Edward Livingston Trudeau (1848-1915), the,founder and first president ... of Tuberculosis, the precursor to the American Lung ... treating tuberculosis, a,highly infectious disease that at one ...
... Indoor Air Professionals advises consumers on indoor air quality, ... Asthma Awareness Month,according the Environmental Protection Agency (EPA), and ... consumers on the,importance of clean indoor air in relation ... nearly 2 million Americans to the emergency,room in the ...
... earn both national, ... state kudos, SOUTHFIELD, Mich., May 12 ... Care Network of,Michigan., BCN is one of 20 companies worldwide receiving the ... the second year,in a row BCN has earned the annual award. On May ...
Cached Medicine News:Health News:Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel 2Health News:Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel 3Health News:Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel 4Health News:Salient Corporation's Performance Management Solution Helps NY State Counties Identify Medicaid Fraud, Waste, and Abuse 2Health News:Paro, the World's Only Robotic Baby Harp Seal - Designed Specifically for Therapy - to be Focus of Industry Event at Vinson Hall Retirement Community in McLean, Va., June 2 2Health News:American Lung Association Founder Honored With New U.S. Postage Stamp 2Health News:Asthma Awareness Month Spawns Healthy Advice 2Health News:Blue Care Network of Michigan Named a Great Workplace by Gallup, MBPA 2Health News:Blue Care Network of Michigan Named a Great Workplace by Gallup, MBPA 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... used in the ARED study, as well ... which suggested no AMD disease progression in ... period. Macula Complete also contains efficacious amounts ... support the mitochondria, as well as to ...
... MacularProtect delivers levels of ... vision and macular health in ... by The National Eye Institute. ... of lutein, an antioxidant found ...
... is a scientifically advanced nutritional formulation ... and full body health. MacularProtect Complete ... trial and other advanced research. It ... provides a broad foundation of antioxidants, ...
Medicine Products: