Navigation Links
Telomerase Presentations at the AACR 2007 Annual Meeting

>

Cancer Stem Cells

Cancer stem cells (CSCs) are a rare sub-population of self-renewing, immortal tumor cells capable of differentiating into the various types of cells seen within the bulk tumor. They are now widely believed to be distinct from the bulk tumor cells and to be responsible for many cases of drug resistance and cancer recurrence. The 2007 AACR meeting had a dramatic increase in CSC presentations, and there is a growing awareness that effective cancer treatment will require drugs that kill CSCs.

At previous cancer meetings, Drs. W. Matsui and R. Jones of Johns Hopkins University reported on telomerase activity in myeloma stem cells. The Johns Hopkins team demonstrated that Geron's telomerase inhibitor, GRN163L, blocked growth and colony formation in both the stem and differentiated subpopulations of myeloma cells. In these studies, no other compounds have been shown to be as active against myeloma CSCs. Geron is currently planning a trial with GRN163L in myeloma patients.

Other Telomerase and Telomere Presentations

Other studies presented at the AACR meeting focused on the degree of telomere loss prior to telomerase activation in various tumor types, the role of telomere dysfunction in tumorigenesis, and use of the telomerase promoter to drive tumor cell death.

"The data presented at AACR contribute to the growing body of evidence regarding the importance of telomerase targeted therapies for the treatment of cancer," noted Alan Colowick, M.D., M.P.H., Geron's president, oncology. "Geron currently has two clinical studies of GRN163L underway in patients with chronic lymphocytic leukemia (CLL) and solid tumor malignancies. We plan to initiate two additional studies of GRN163L in patients with multiple myeloma and non-small cell lung cancer, as well as a study of GRNVAC1 in patients with acute myelogenous leukemia (AML), in the months ahead.

Geron is developing first-in-class biopharmaceuticals for the treatment
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits
2. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
3. Generex Biotechnology to Make Presentations At 46th Annual Meeting of the European Society of Pediatric Endocrinology
4. Nuvelo Announces Presentations on rNAPc2 and NU172 at the XXIst Congress of the International Society on Thrombosis and Haemostasis
5. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
6. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois
7. Inspire Announces Presentations at Two European Scientific Conferences
8. Presentations at 2007 European Stroke Congress Highlights New Direction for Viprinex (ancrod)
9. IDM Pharma Announces UVIDEM(R) and EP-2101 Data Presentations at 2007 ASCO Annual Meeting
10. MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
11. Pharmacyclics Announces Presentations and Published Abstracts on Xcytrin at The 2007 American Society of Clinical Oncology Annual Meeting

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Telomerase Presentations the AACR Annual Meeting
(Date:11/6/2009)...TOWN, N.J., Nov. 6 Watso...pecialty pharmaceutical company, announced today t...utive officer, will provide an overview and update...th Annual Healthcare Conference on Wednesday, Nove..., This presentation will be webcast live and ca...
(Date:11/6/2009)...TA, Fla., Nov. 6 Roper ...at it has signed a definitive agreement to acquire... medical devices. The Verathon Board of Directors...ubject to customary regulatory approvals and closi...e parties expect the closing to be completed in ea...
(Date:11/6/2009)...GTON, Nov. 6 America,s ...working group of mid-market and smaller innovator ... about H.R. 3962, the "Affordable Health Care for ...hursday. These smaller companies fear that the cu...62 will hinder their efforts to bring new medicine...
Breaking Medicine Technology:Roper Industries Announces Two Acquisitions to Enhance Growth in Medical and Toll & Traffic Businesses 2Roper Industries Announces Two Acquisitions to Enhance Growth in Medical and Toll & Traffic Businesses 3Statement of America's Specialty Medicines Companies On House Health Care Bill (H.R. 3962) 2Consecos Four Major Offices Wrap Up Record Breaking United Way Campaign 59579 1Consecos Four Major Offices Wrap Up Record Breaking United Way Campaign 59579 2BioMed Realty Trust to Report 2009 Third Quarter Results 59577 1BioMed Realty Trust to Report 2009 Third Quarter Results 59577 2ADVENTRX Pharmaceuticals to Present at the BIOCOM Investor Conference on October 26 5520 1
(Date:11/8/2009)... Tonight the House of Re...r America Act, landmark health reform legislation ...ity, affordable, stable and secure health care cov...of the insurance industry,s worst practices, would...he deficit by $104 billion over ten years. Groups ...
(Date:11/8/2009)... Freeze-drying of biopharmaceuticals to be availab...ility. , Toronto, ON (PR... and CEO of Therapure Biopharma Inc. today announc...cial scale pharmaceutical grade freeze dryer and e...philization) available for contract manufacturing ...
(Date:11/8/2009)... Today, the House of Rep...lkemper, Smith, Ellsworth and Lipinski amendment t...R. 3962). The amendment maintains the current poli...for benefits packages that include abortion. It cl...ffordability credits and those who do not, can wit...
(Date:11/8/2009)... USAction this evening h...erica Act, which will make health care more afford...ntable and increase access to health care for mill...Teddy Roosevelt, FDR and Harry Truman would be pro..."Today,s vote ranks among our country,s proudest a...
(Date:11/8/2009)... The following was relea...scue Insurrecta Nex. ,, Mr. Terry and his asso...to keep child-killing by abortion out of any healt...his is a great first step to victory -- a touchdow...hting ahead of us. Our rejoicing must be tempered ...
Breaking Medicine News(10 mins):Health News:Democratic National Committee Chairman Tim Kaine Issues Statement Praising the House of Representative's Historic Vote to Pass Health Insurance Reform 2Health News:Democratic National Committee Chairman Tim Kaine Issues Statement Praising the House of Representative's Historic Vote to Pass Health Insurance Reform 3Health News:Therapure Biopharma Inc. Announces Delivery of its First Commercial-Scale Lyophilizer 2Health News:Family Research Council Praises Passage of Pro-life Amendment to Health Care Bill 2
...la., Nov. 20 The State of Arkansas,Department of ...elected,U.S. Care Management (formally Specialty D...nt health management services to assist in improvi...tenden, Phillips and St. Francis Counties, Arkansa...
...f., Nov. 20 2007 Vase or face" When presented wit...either a vase or the faces of two people, what we ... going on in our brains. , In this example, whe... UC Irvine cognitive neuroscientist. , In a rece...
...ood volume produced in the obese may so dilute lev...at the popular PSA test may be essentially useless...tra pounds, a new study in The Journal of the Amer...and elsewhere, could eventually affect the reliabi...
...ts their higher blood volume explains it , ...years, doctors have learned that they need to adju... prostate cancer in obese men, but now researchers...e trouble. , The new study doesn,t definitively pr...
...family of products offers formulas of essential pr...n, SAN ANTONIO, Nov. 20 Mission Pharmacal today ...of prescription prenatal vitamins.,The CitraNatal ...iod. These new products include CitraNatal(TM) DHA...
... for parents to teach children how to keep hands c...inutes, a child puts a hand in his/her nose or mou... live two hours or longer on surfaces like,cafeter...ng to the Centers for Disease Control and Preventi...
Other Medicine News:Health News:State of Arkansas Department of Human Services, Division of Medical Services Selects U.S. Care Management for High-Risk Obstetrics Health Management Program 2Health News:State of Arkansas Department of Human Services, Division of Medical Services Selects U.S. Care Management for High-Risk Obstetrics Health Management Program 3Health News:State of Arkansas Department of Human Services, Division of Medical Services Selects U.S. Care Management for High-Risk Obstetrics Health Management Program 4Health News:Scientists uncover how the brain controls what the eyes see 2Health News:Obesity-linked high blood volumes render PSA prostate cancer test less effective, study suggests 2Health News:Why Obese Men Post Lower PSA Levels 2Health News:Mission Pharmacal Launches CitraNatal(TM) Prescription Prenatal Vitamin Line 2Health News:Proper Hand Hygiene Is Key to Avoiding Illness During Cold and Flu Season 2
...a laser system with one single wavelength of 1064n...us intensities of either 60 W or 100 W, and it is ...ues. This laser is the classical version of Smart1...tals and clinics which would like to have a versat...
SmartChill
...been designed exclusively for vascular treatments,...epil range which ensures fast amortisation of the ...ems, it can be fitted with a polarised light viewi... target to be treated as well as the operators max...
...:YAG) laser is the ideal instrument for safe, repe...s, the majority of surface lesions can be treated,...e, with a minimum of heat damage and in most cases...dverse side effects. Smart 2940 Plus incorporates ...
Medicine Products: